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. 1980;10(Suppl 2):261S–278S. doi: 10.1111/j.1365-2125.1980.tb01809.x

Potential therapeutic applications of aspirin and other cyclo-oxygenase inhibitors

A E Farah, F Rosenberg
PMCID: PMC1430184  PMID: 6776977

Abstract

1 The ubiquitous actions of the cyclo-oxygenase inhibitors are described.

2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines.

3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin.

4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno-allograft rejection are discussed.

5 The beneficial and adverse effects on the gastro-intestinal tract are described.

6 The effects of aspirin-like drugs on the genito-urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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