Abstract
1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose related, and blocked by prior administration of propranolol. 3 When isoprenaline was given immediately before the paracetamol, absorption was not altered, although a cardiovascular response was seen. 4 Oral salbutamol also delayed paracetamol absorption. 5 Propranolol given alone increased the rate of paracetamol absorption. 6 These results with the changes in the rate of gastric emptying produced by these agents.
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Selected References
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- Bianchine J. R., Calimlim L. R., Morgan J. P., Dujuvne C. A., Lasagna L. Metabolism and absorption of L-3,4 dihydroxyphenylalanine in patients with Parkinson's disease. Ann N Y Acad Sci. 1971 Jul 6;179:126–140. doi: 10.1111/j.1749-6632.1971.tb46895.x. [DOI] [PubMed] [Google Scholar]
- Consolo S., Morselli P. L., Zaccala M., Garattini S. Delayed absorption of phenylbutazone caused by desmethylimipramine in humans. Eur J Pharmacol. 1970 May;10(2):239–242. doi: 10.1016/0014-2999(70)90278-5. [DOI] [PubMed] [Google Scholar]
- Hall R. C., Brown D., Carter R., Kendall M. J. The effect of desmethylimipramine on the absorption of alcohol and paracetamol. Postgrad Med J. 1976 Mar;52(605):139–142. doi: 10.1136/pgmj.52.605.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levine R. R. Factors affecting gastrointestinal absorption of drugs. Am J Dig Dis. 1970 Feb;15(2):171–188. doi: 10.1007/BF02235648. [DOI] [PubMed] [Google Scholar]
- Levy G., Gibaldi M., Procknal J. A. Effect of an anticholinergic agent on riboflavin absorption in man. J Pharm Sci. 1972 May;61(5):798–799. doi: 10.1002/jps.2600610529. [DOI] [PubMed] [Google Scholar]
- MARCUS C. S., LENGEMANN F. W. Absorption of Ca45 and Sr85 from solid and liquid food at various levels of the alimentary tract of the rat. J Nutr. 1962 Jun;77:155–160. doi: 10.1093/jn/77.2.155. [DOI] [PubMed] [Google Scholar]
- Manninen V., Apajalahti A., Melin J., Karesoja M. Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet. 1973 Feb 24;1(7800):398–400. doi: 10.1016/s0140-6736(73)90252-3. [DOI] [PubMed] [Google Scholar]
- Nimmo J., Heading R. C., Tothill P., Prescott L. F. Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J. 1973 Mar 10;1(5853):587–589. doi: 10.1136/bmj.1.5853.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prescott L. F. Gas-liquid chromatographic estimation of paracetamol. J Pharm Pharmacol. 1971 Oct;23(10):807–808. doi: 10.1111/j.2042-7158.1971.tb08613.x. [DOI] [PubMed] [Google Scholar]
- Prescott L. F. The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine. J Pharm Pharmacol. 1971 Feb;23(2):111–115. doi: 10.1111/j.2042-7158.1971.tb08622.x. [DOI] [PubMed] [Google Scholar]
- Rivera-Calimlim L., Castañeda L., Lasagna L. Effects of mode of management on plasma chlorpromazine in psychiatric patients. Clin Pharmacol Ther. 1973 Nov-Dec;14(6):978–986. doi: 10.1002/cpt1973146978. [DOI] [PubMed] [Google Scholar]
- Talbot R. G., Nimmo J., Julian D. G., Clark R. A., Neilson J. M., Prescott L. F. Treatment of ventricular arrhythmias with mexiletine (Kö 1173). Lancet. 1973 Aug 25;2(7826):399–404. doi: 10.1016/s0140-6736(73)92270-8. [DOI] [PubMed] [Google Scholar]