Skip to main content
PMC home page
Gut logoLink to Gut
. 1984 Feb;25(2):206–210. doi: 10.1136/gut.25.2.206

Treatment of duodenal ulcer with pirenzepine and cimetidine.

H Brunner, H Dittrich, P Kratochvil, G Brandstätter, E Hentschel, K Schütze, K H Tragl, H Kern, K Löffelmann, H Zeiler, et al.
PMCID: PMC1432257  PMID: 6363220

Abstract

The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfast and before the evening meal), and 128 patients were treated with 1000 mg cimetidine (200 mg with breakfast, lunch, and evening meal and 400 mg at bedtime). Endoscopy was repeated after four weeks by an endoscopist who had not been informed about the treatment. Pirenzepine showed a healing rate of 64.3%, cimetidine one of 73.4%. This difference is not statistically significant (one-sided test: chi 1(2) = 2.48). After four weeks a higher proportion of first ulcers than of recurrent lesions was healed. Pain relief was rapidly achieved with both drugs. A significant trend in favour of cimetidine may, however, not be clinically relevant considering the small difference in the absolute numbers of pain free days and nights. Adverse effects were rare and reversible. We conclude that the efficacy of pirenzepine is similar to that of cimetidine in healing duodenal ulcers.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianchi Porro G., Petrillo M. Pirenzepine in the treatment of peptic ulcer disease. Review and commentary. Scand J Gastroenterol Suppl. 1982;72:229–236. [PubMed] [Google Scholar]
  2. Bozler G., Hammer R. An international pharmacokinetic study on pirenzepine following a single oral dose. Scand J Gastroenterol Suppl. 1980;66:27–33. [PubMed] [Google Scholar]
  3. Eichenberger P. M., Giger M., Mattle W., Pelloni S., Müller-Lissner S. A., Gonvers J. J., Birchler R., Blum A. L. Treatment and relapse prophylaxis of duodenal ulcer with pirenzepine and cimetidine. Scand J Gastroenterol Suppl. 1982;72:197–205. [PubMed] [Google Scholar]
  4. Giger M., Gonvers J. J., Weber K. B., Sonnenberg A., Birchler R., Mattle W., Hofstetter J. R., Blum A. L. Therapie des Ulcus duodeni mit Cimetidin, Pirenzepin und Placebo: Bericht über eine doppeltblinde, randomisierte Studie. Schweiz Med Wochenschr. 1979 Apr 21;109(16):617–618. [PubMed] [Google Scholar]
  5. Hammer R., Berrie C. P., Birdsall N. J., Burgen A. S., Hulme E. C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 1980 Jan 3;283(5742):90–92. doi: 10.1038/283090a0. [DOI] [PubMed] [Google Scholar]
  6. Hentschel E., Schütze K., Havelec L. Die Behandlung des Ulcus duodeni und des präpylorischen Ulcus ventriculi mit Cimetidin. Wien Klin Wochenschr. 1979 Jan 19;91(2):53–57. [PubMed] [Google Scholar]
  7. Ivey K. J. Anticholinergics: do they work in peptic ulcer? Gastroenterology. 1975 Jan;68(1):154–166. [PubMed] [Google Scholar]
  8. Stockbrügger R. W., Jaup B. H., Dotevall G. The effect of different doses of pirenzepine on gastric secretion stimulated by modified shamfeeding in man. Scand J Gastroenterol Suppl. 1982;72:111–117. [PubMed] [Google Scholar]
  9. Walkenstein S. S., Dubb J. W., Randolph W. C., Westlake W. J., Stote R. M., Intoccia A. P. Bioavailability of cimetidine in man. Gastroenterology. 1978 Feb;74(2 Pt 2):360–365. [PubMed] [Google Scholar]
  10. Winship D. H. Cimetidine in the treatment of duodenal ulcer: review and commentary. Gastroenterology. 1978 Feb;74(2 Pt 2):402–406. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES