Skip to main content
Gut logoLink to Gut
. 1984 Sep;25(9):1003–1008. doi: 10.1136/gut.25.9.1003

Coeliac disease presenting with intestinal pseudo-obstruction.

D J Dawson, C M Sciberras, H Whitwell
PMCID: PMC1432479  PMID: 6547920

Abstract

A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a case of coeliac disease with secondary pseudo-obstruction, rather than primary intestinal pseudo-obstruction with secondary bacterial overgrowth, is discussed.

Full text

PDF
1003

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ament M. E., Shimoda S. S., Saunders D. R., Rubin C. E. Pathogenesis of steatorrhea in three cases of small intestinal stasis syndrome. Gastroenterology. 1972 Nov;63(5):728–747. [PubMed] [Google Scholar]
  2. Barry R. E., Read A. E. Coeliac disease and malignancy. Q J Med. 1973 Oct;42(168):665–675. [PubMed] [Google Scholar]
  3. Booth C. C. Enterocyte in coeliac disease. 1. Br Med J. 1970 Sep 26;3(5725):725–731. doi: 10.1136/bmj.3.5725.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DUDLEY H. A., SINCLAIR I. S., McLAREN I. F., McNAIR T. J., NEWSAM J. E. Intestinal pseudo-obstruction. J R Coll Surg Edinb. 1958 Mar;3(3):206–217. [PubMed] [Google Scholar]
  5. Drenick E. J., Ament M. E., Finegold S. M., Passaro E., Jr Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. Am J Clin Nutr. 1977 Jan;30(1):76–89. doi: 10.1093/ajcn/30.1.76. [DOI] [PubMed] [Google Scholar]
  6. Dyer N. H., Dawson A. M., Smith B. F., Todd I. P. Obstruction of bowel due to lesion in the myenteric plexus. Br Med J. 1969 Mar 15;1(5645):686–689. doi: 10.1136/bmj.1.5645.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Faulk D. L., Anuras S., Christensen J. Chronic intestinal pseudoobstruction. Gastroenterology. 1978 May;74(5 Pt 1):922–931. [PubMed] [Google Scholar]
  8. Fordtran J. S., Rector F. C., Locklear T. W., Ewton M. F. Water and solute movement in the small intestine of patients with sprue. J Clin Invest. 1967 Mar;46(3):287–298. doi: 10.1172/JCI105531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LIFSHITZ F., KLOTZ A. P., HOLMAN G. H. INTESTINAL DISACCHARIDASE DEFICIENCIES IN GLUTEN-SENSITIVE ENTEROPATHY. Am J Dig Dis. 1965 Jan;10:47–57. doi: 10.1007/BF02235075. [DOI] [PubMed] [Google Scholar]
  10. Lipton A. B., Knauer C. M. Pseudo-obstruction of the bowel. Therapeutic trial of metoclopramide. Am J Dig Dis. 1977 Mar;22(3):263–265. doi: 10.1007/BF01072287. [DOI] [PubMed] [Google Scholar]
  11. Luderer J. R., Demers L. M., Bonnem E. M., Saleem A., Jeffries G. H. Elevated prostaglandin e in idiopathic intestinal pseudo-obstruction. N Engl J Med. 1976 Nov 18;295(21):1179–1179. doi: 10.1056/NEJM197611182952109. [DOI] [PubMed] [Google Scholar]
  12. MACDONALD W. C., BRANDBORG L. L., FLICK A. L., TRIER J. S., RUBIN C. E. STUDIES OF CELIAC SPRUE. IV. THE RESPONSE OF THE WHOLE LENGTH OF THE SMALL BOWEL TO A GLUTEN-FREE DIET. Gastroenterology. 1964 Dec;47:573–589. [PubMed] [Google Scholar]
  13. McClelland H. A., Lewis M. J., Naish J. M. Idiopathic steatorrhoea with intestinal pseudo-obstruction. Gut. 1962 Jun;3(2):142–145. doi: 10.1136/gut.3.2.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. NAISH J. M., CAPPER W. M., BROWN N. J. Intestinal pseudoobstruction with steatorrhoea. Gut. 1960 Mar;1:62–66. doi: 10.1136/gut.1.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Schuffler M. D., Kaplan L. R., Johnson L. Small-intestinal mucosa in pseudoobstruction syndromes. Am J Dig Dis. 1978 Sep;23(9):821–828. doi: 10.1007/BF01079792. [DOI] [PubMed] [Google Scholar]
  16. Schuffler M. D., Lowe M. C., Bill A. H. Studies of idiopathic intestinal pseudoobstruction. I. Hereditary hollow visceral myopathy: clinical and pathological studies. Gastroenterology. 1977 Aug;73(2):327–338. [PubMed] [Google Scholar]
  17. Seah P. P., Fry L., Holborow E. J., Rossiter M. A., Doe W. F., Magalhaes A. F., Hoffbrand A. V. Antireticulin antibody: incidence and diagnostic significance. Gut. 1973 Apr;14(4):311–315. doi: 10.1136/gut.14.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Seelig L. L., Jr, Winborn W. B., Weser E. Effect of small bowel resection on the gastric mucosa in the rat. Gastroenterology. 1977 Mar;72(3):421–428. [PubMed] [Google Scholar]
  19. Short bowel syndrome. Gastroenterology. 1979 Sep;77(3):572–579. [PubMed] [Google Scholar]
  20. Stevens F. M., Lloyd R., Egan-Mitchell B., Mylotte M. J., Fottrell P. F., Wright R., McNicholl B., McCarthy C. F. Reticulin antibodies in patients with coeliac disease and their relatives. Gut. 1975 Aug;16(8):598–602. doi: 10.1136/gut.16.8.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stokes P. L., Asquith P., Holmes G. K., Mackintosh P., Cooke W. T. Histocompatibility antigens associated with adult coeliac disease. Lancet. 1972 Jul 22;2(7769):162–164. doi: 10.1016/s0140-6736(72)91330-x. [DOI] [PubMed] [Google Scholar]
  22. Wickbom G., Landor J. H., Bushkin F. L., McGuigan J. E. Changes in canine gastric acid output and serum gastrin levels following massive small intestinal resection. Gastroenterology. 1975 Aug;69(2):448–452. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES