Abstract
We investigated the possibility that loperamide might influence absorption and secretion in the human jejunum in vivo. Using a triple lumen tube perfusion technique in healthy normal volunteers we showed that loperamide did not affect net absorption of water or electrolytes under basal condition. When secretion was induced by prostaglandin E2, however, loperamide significantly reduced that secretion and in three out of six subjects secretion was abolished. Loperamide was effective when it was given either before or after secretion had been initiated. The results lend support to the suggestion that the antidiarrhoeal activities of loperamide may include an antisecretory effect.
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Selected References
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- DANIEL E. E., SUTHERLAND W. H., BOGOCH A. Effects of morphine and other drugs on motility of the terminal ileum. Gastroenterology. 1959 Apr;36(4):510–523. [PubMed] [Google Scholar]
- Davis G. R., Santa Ana C. A., Morawski S., Fordtran J. S. Active chloride secretion in the normal human jejunum. J Clin Invest. 1980 Dec;66(6):1326–1333. doi: 10.1172/JCI109985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fordtran J. S., Rector F. C., Jr, Carter N. W. The mechanisms of sodium absorption in the human small intestine. J Clin Invest. 1968 Apr;47(4):884–900. doi: 10.1172/JCI105781. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kachur J. F., Miller R. J., Field M. Control of guinea pig intestinal electrolyte secretion by a delta-opiate receptor. Proc Natl Acad Sci U S A. 1980 May;77(5):2753–2756. doi: 10.1073/pnas.77.5.2753. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKay J. S., Linaker B. D., Higgs N. B., Turnberg L. A. Studies of the antisecretory activity of morphine in rabbit ileum in vitro. Gastroenterology. 1982 Feb;82(2):243–247. [PubMed] [Google Scholar]
- Morris A. I., Turnberg L. A. The influence of a parasympathetic agonist and antagonist on human intestinal transport in vivo. Gastroenterology. 1980 Nov;79(5 Pt 1):861–866. [PubMed] [Google Scholar]
- Sandhu B. K., Tripp J. H., Candy D. C., Harries J. T. Loperamide: studies on its mechanism of action. Gut. 1981 Aug;22(8):658–662. doi: 10.1136/gut.22.8.658. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sandhu B. K., Tripp J. H., Milla P. J., Harries J. T. Loperamide in severe protracted diarrhoea. Arch Dis Child. 1983 Jan;58(1):39–43. doi: 10.1136/adc.58.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schiller L. R., Davis G. R., Santa Ana C. A., Morawski S. G., Fordtran J. S. Studies of the mechanism of the antidiarrheal effect of codeine. J Clin Invest. 1982 Nov;70(5):999–1008. doi: 10.1172/JCI110711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Nueten J. M., Janssen P. A., Fontaine J. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 3: in vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneimittelforschung. 1974 Oct;24(10):1641–1645. [PubMed] [Google Scholar]
- Verhaegen H., De Cree J., Schuermans V. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 7: Clinical investigation. Efficacy and safety of loperamide in patients with severe chronic diarrhea. Arzneimittelforschung. 1974 Oct;24(10):1657–1660. [PubMed] [Google Scholar]
- Whicher J. T., Barnes M. P., Brown A., Cooper M. J., Read R., Walters G., Williamson R. C. Complement activation and complement control proteins in acute pancreatitis. Gut. 1982 Nov;23(11):944–950. doi: 10.1136/gut.23.11.944. [DOI] [PMC free article] [PubMed] [Google Scholar]
- von Mühlendahl K. E., Bunjes R., Krienke E. G. Loperamide-induced ileus. Lancet. 1980 Jan 26;1(8161):209–209. doi: 10.1016/s0140-6736(80)90697-2. [DOI] [PubMed] [Google Scholar]