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. 1984 Sep;25(9):957–964. doi: 10.1136/gut.25.9.957

Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.

B K Sharma, R P Walt, R E Pounder, M D Gomes, E C Wood, L H Logan
PMCID: PMC1432495  PMID: 6469081

Abstract

In a series of 59 experiments in nine duodenal ulcer patients, 24 hour intragastric acidity was measured before, during, and after treatment with daily oral omeprazole. Omeprazole 10, 20, and 30 mg/day for one week caused a 37, 90, and 97% decrease of 24 hour intragastric acidity, respectively. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses) there was a significant 26% decrease of 24 hour intragastric acidity, with full recovery seven weeks later. Fasting plasma gastrin concentration was significantly raised during treatment with all doses of omeprazole. Omeprazole 30 mg/day is the optimal dose for a maximal decrease of 24 hour intragastric acidity in duodenal ulcer patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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