Abstract
The frequency of adenomas of the large intestine in 331 cholecystectomised patients who underwent total colonoscopy was compared with that of a control group of patients with asymptomatic cholelithiasis who were matched for age and sex. Whereas no significant difference in the frequency of adenomas was found between two groups, a subgroup of patients aged 60-80 years with a postcholecystectomy interval of 10 years or greater exhibited a significantly (p less than 0.05) greater frequency of adenomas (38.5%) than matched patients with a postcholecystectomy interval of less than 10 years (21.8%) and matched controls with cholelithiasis (23.7%). This increase in the frequency of adenomas was primarily accounted for by an increase in the percentage of tubular adenomas (p less than 0.05) and corresponded to an increase in the frequency of cancer (p less than 0.05) of the large bowel.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Capron J. P., Delamarre J., Canarelli J. P., Brousse N., Dupas J. L. La cholécystectomie favorise-t-elle l'apparition du cancer rectocolique? Gastroenterol Clin Biol. 1978 Apr;2(4):383–389. [PubMed] [Google Scholar]
- Castleden W. M., Doouss T. W., Jennings K. P., Leighton M. Gallstones, carcinoma of the colon and diverticular disease. Clin Oncol. 1978 Jun;4(2):139–144. [PubMed] [Google Scholar]
- Hepner G. W., Hofmann A. F., Malagelada J. R., Szczepanik P. A., Klein P. D. Increased bacterial degradation of bile acids in cholecystectomized patients. Gastroenterology. 1974 Apr;66(4):556–564. [PubMed] [Google Scholar]
- Hill M. J., Morson B. C., Bussey H. J. Aetiology of adenoma--carcinoma sequence in large bowel. Lancet. 1978 Feb 4;1(8058):245–247. doi: 10.1016/s0140-6736(78)90487-7. [DOI] [PubMed] [Google Scholar]
- Hill M. J. The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer. Cancer. 1975 Dec;36(6 Suppl):2387–2400. doi: 10.1002/1097-0142(197512)36:6<2387::aid-cncr2820360618>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Hoare A. M. Letter: Carcinoma of the colon and cholecystectomy. Lancet. 1974 Dec 7;2(7893):1395–1396. doi: 10.1016/s0140-6736(74)92276-4. [DOI] [PubMed] [Google Scholar]
- Linos D., Beard C. M., O'Fallon W. M., Dockerty M. B., Beart R. W., Jr, Kurland L. T. Cholecystectomy and carcinoma of the colon. Lancet. 1981 Aug 22;2(8243):379–381. doi: 10.1016/s0140-6736(81)90829-1. [DOI] [PubMed] [Google Scholar]
- Morson B. President's address. The polyp-cancer sequence in the large bowel. Proc R Soc Med. 1974 Jun;67(6 Pt 1):451–457. [PMC free article] [PubMed] [Google Scholar]
- Peters H., Keimes A. M. Die Cholezystektomie als prädisponierender Faktor in der Genese des kolorektalen Karzinoms? Dtsch Med Wochenschr. 1979 Nov 9;104(45):1581–1583. doi: 10.1055/s-0028-1129148. [DOI] [PubMed] [Google Scholar]
- Pomare E. W., Heaton K. W. The effect of cholecystectomy on bile salt metabolism. Gut. 1973 Oct;14(10):753–762. [PMC free article] [PubMed] [Google Scholar]
- Reddy B. S., Wynder E. L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977 Jun;39(6):2533–2539. doi: 10.1002/1097-0142(197706)39:6<2533::aid-cncr2820390634>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
- Schattenkerk M. E., Li A. K., Jeppsson B. W., Eggink W. F., Jamieson C. G., Ross J. S., Malt R. A. Cholecystectomy has no influence on frequency of chemically induced colonic cancer in mice. Br J Cancer. 1980 Nov;42(5):791–793. doi: 10.1038/bjc.1980.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaffer E. A., Braasch J. W., Small D. M. Bile composition at and after surgery in normal persons and patients with gallstones. Influence of cholecystectomy. N Engl J Med. 1972 Dec 28;287(26):1317–1322. doi: 10.1056/NEJM197212282872603. [DOI] [PubMed] [Google Scholar]
- Thistle J. L. Gallstones in women. Med Clin North Am. 1974 Jul;58(4):811–816. doi: 10.1016/s0025-7125(16)32123-x. [DOI] [PubMed] [Google Scholar]
- Turunen M. J., Kivilaakso E. O. Increased risk of colorectal cancer after cholecystectomy. Ann Surg. 1981 Nov;194(5):639–641. doi: 10.1097/00000658-198111000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vernick L. J., Kuller L. H. Cholecystectomy and right-sided colon cancer: an epidemiological study. Lancet. 1981 Aug 22;2(8243):381–383. doi: 10.1016/s0140-6736(81)90830-8. [DOI] [PubMed] [Google Scholar]
- Vernick L. J., Kuller L. H., Lohsoonthorn P., Rycheck R. R., Redmond C. K. Relationship between cholecystectomy and ascending colon cancer. Cancer. 1980 Jan 15;45(2):392–395. doi: 10.1002/1097-0142(19800115)45:2<392::aid-cncr2820450234>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
- Vobecky J., Caro J., Devroede G. A case-control study of risk factors for large bowel carcinoma. Cancer. 1983 May 15;51(10):1958–1963. doi: 10.1002/1097-0142(19830515)51:10<1958::aid-cncr2820511036>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Werner B., de Heer K., Mitschke H. Cholecystectomy and carcinoma of the colon. An experimental study. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):223–230. doi: 10.1007/BF00305360. [DOI] [PubMed] [Google Scholar]
- van der Werf S. D., Huijbregts A. W., Lamers H. L., van Berge Henegouwen G. P., van Tongeren J. H. Age dependent differences in human bile acid metabolism and 7 alpha-dehydroxylation. Eur J Clin Invest. 1981 Dec;11(6):425–431. doi: 10.1111/j.1365-2362.1981.tb02009.x. [DOI] [PubMed] [Google Scholar]