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. 1985 Mar;26(3):241–245. doi: 10.1136/gut.26.3.241

Evaluation of pirenzepine on gastric acidity in healthy volunteers using ambulatory 24 hour intragastric pH-monitoring.

A Etienne, C J Fimmel, B A Bron, E Loizeau, A L Blum
PMCID: PMC1432615  PMID: 3882525

Abstract

The effect of pirenzepine on 24 hour intragastric acidity was studied in 10 healthy volunteers using ambulatory 24 hour intragastric pH-monitoring in a double blind crossover study. Tests were performed on the seventh day of ingestion of either placebo, 75 mg pirenzepine or 150 mg pirenzepine per day. The drugs were given at two doses at 8.30 am and 8.30 pm. Mean nocturnal hydrogen ion activity during placebo treatment was 68 mmol/l +/- 9 SEM and was reduced by 75 mg (26%, p less than 0.01) and 150 mg of pirenzepine (36%, p less than 0.01), respectively. Mean diurnal hydrogen ion activity was 32 mmol/l +/- 6 SEM and was not significantly reduced (p greater than 0.1) by either dose of pirenzepine (4% and 12% respectively). Thus, the effect of pirenzepine on intragastric acidity is small, even with high doses of the drug, and becomes apparent only during the night.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianchi Porro G., Petrillo M. Pirenzepine in the treatment of peptic ulcer disease. Review and commentary. Scand J Gastroenterol Suppl. 1982;72:229–236. [PubMed] [Google Scholar]
  2. Brunner H., Dittrich H., Kratochvil P., Brandstätter G., Hentschel E., Schütze K., Tragl K. H., Kern H., Löffelmann K., Zeiler H. Treatment of duodenal ulcer with pirenzepine and cimetidine. Gut. 1984 Feb;25(2):206–210. doi: 10.1136/gut.25.2.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gustavsson S., Adami H. O., Löf L., Nyberg A., Nyrén O. Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial. Lancet. 1983 Jul 16;2(8342):124–125. doi: 10.1016/s0140-6736(83)90114-9. [DOI] [PubMed] [Google Scholar]
  4. Hammer R., Berrie C. P., Birdsall N. J., Burgen A. S., Hulme E. C. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature. 1980 Jan 3;283(5742):90–92. doi: 10.1038/283090a0. [DOI] [PubMed] [Google Scholar]
  5. Isenberg J. I., Peterson W. L., Elashoff J. D., Sandersfeld M. A., Reedy T. J., Ippoliti A. F., Van Deventer G. M., Frankl H., Longstreth G. F., Anderson D. S. Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. N Engl J Med. 1983 Jun 2;308(22):1319–1324. doi: 10.1056/NEJM198306023082203. [DOI] [PubMed] [Google Scholar]
  6. Jaup B. H., Stockbrügger R. W., Dotevall G. Comparison of the action of pirenzepine and L-hyoscyamine on gastric acid secretion and other muscarinic effects. Scand J Gastroenterol Suppl. 1980;66:89–94. [PubMed] [Google Scholar]
  7. MOORE E. W., SCARLATA R. W. THE DETERMINATION OF GASTRIC ACIDITY BY THE GLASS ELECTRODE. Gastroenterology. 1965 Aug;49:178–188. [PubMed] [Google Scholar]
  8. Peterson W. L., Barnett C., Feldman M., Richardson C. T. Reduction of twenty-four-hour gastric acidity with combination drug therapy in patients with duodenal ulcer. Gastroenterology. 1979 Nov;77(5):1015–1020. [PubMed] [Google Scholar]
  9. Walt R. P., Gomes M. D., Wood E. C., Logan L. H., Pounder R. E. Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J (Clin Res Ed) 1983 Jul 2;287(6384):12–14. doi: 10.1136/bmj.287.6384.12. [DOI] [PMC free article] [PubMed] [Google Scholar]

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