Skip to main content
NCBI home page
Gut logoLink to Gut
. 1987 Mar;28(3):306–314. doi: 10.1136/gut.28.3.306

Gastric and duodenal polyps in familial adenomatous polyposis: a prospective study of the nature and prevalence of upper gastrointestinal polyps.

R G Sarre, A G Frost, D G Jagelman, R E Petras, M V Sivak, E McGannon
PMCID: PMC1432679  PMID: 3032754

Abstract

One hundred patients with familial adenomatous polyposis have prospectively undergone gastroduodenoscopy to identify and characterise polyps found. Forty six patients had polyps in the stomach or duodenum. Thirty five patients had adenomas (33 in duodenum, two in stomach) and 26 patients had fundic gland polyps. Some of these patients had polyps in the stomach and the duodenum. Adenomas in the duodenum were present in 33% of patients studied with Gardner's syndrome variant (p = 0.04). Adenomas were also more common in older patients. As adenomas may be a precursor of adenocarcinoma, routine surveillance of the stomach and duodenum with gastroduodenoscopy is recommended in patients affected with familial adenomatous polyposis.

Full text

PDF
306

Images in this article

308Fig. 1
on p.308
308Fig. 2
on p.308
308Fig. 3
on p.308
308Fig. 4
on p.308
309Fig. 5
on p.309
310Fig. 6
on p.310
310Fig. 7
on p.310
311Fig. 8
on p.311
311Fig. 9
on p.311
312Fig. 10
on p.312

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burt R. W., Berenson M. M., Lee R. G., Tolman K. G., Freston J. W., Gardner E. J. Upper gastrointestinal polyps in Gardner's syndrome. Gastroenterology. 1984 Feb;86(2):295–301. [PubMed] [Google Scholar]
  2. Bülow S., Lauritsen K. B., Johansen A., Svendsen L. B., Søndergaard J. O. Gastroduodenal polyps in familial polyposis coli. Dis Colon Rectum. 1985 Feb;28(2):90–93. doi: 10.1007/BF02552651. [DOI] [PubMed] [Google Scholar]
  3. GARDNER E. J., RICHARDS R. C. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet. 1953 Jun;5(2):139–147. [PMC free article] [PubMed] [Google Scholar]
  4. Haglund U., Fork F. T., Genell S., Rehnberg O. Villous adenomas in the duodenum. Br J Surg. 1985 Jan;72(1):26–27. doi: 10.1002/bjs.1800720112. [DOI] [PubMed] [Google Scholar]
  5. Hoffmann D. C., Goligher J. C. Polyposis of the stomach and small intestine in association with familia polyposis coli. Br J Surg. 1971 Feb;58(2):126–128. doi: 10.1002/bjs.1800580212. [DOI] [PubMed] [Google Scholar]
  6. Jones T. R., Nance F. C. Periampullary malignancy in Gardner's syndrome. Ann Surg. 1977 May;185(5):565–573. doi: 10.1097/00000658-197705000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Järvinen H., Nyberg M., Peltokallio P. Upper gastrointestinal tract polyps in familial adenomatosis coli. Gut. 1983 Apr;24(4):333–339. doi: 10.1136/gut.24.4.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kozuka S., Tsubone M., Yamaguchi A., Hachisuka K. Adenomatous residue in cancerous papilla of Vater. Gut. 1981 Dec;22(12):1031–1034. doi: 10.1136/gut.22.12.1031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MURPHY E. S., MIRELES M., BELTRAN A. Familial polyposis of the colon and gastric carcinoma. Concurrent conditions in a 16-year-old boy. JAMA. 1962 Mar 31;179:1026–1028. [PubMed] [Google Scholar]
  10. Ranzi T., Castagnone D., Velio P., Bianchi P., Polli E. E. Gastric and duodenal polyps in familial polyposis coli. Gut. 1981 May;22(5):363–367. doi: 10.1136/gut.22.5.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sener S. F., Miller H. H., DeCosse J. J. The spectrum of polyposis. Surg Gynecol Obstet. 1984 Dec;159(6):525–532. [PubMed] [Google Scholar]
  12. Sugihara K., Muto T., Kamiya J., Konishi F., Sawada T., Morioka Y. Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis. Report of a case. Dis Colon Rectum. 1982 Nov-Dec;25(8):766–771. doi: 10.1007/BF02553308. [DOI] [PubMed] [Google Scholar]
  13. Utsunomiya J., Maki T., Iwama T., Matsunaga Y., Ichikawa T. Gastric lesion of familial polyposis coli. Cancer. 1974 Sep;34(3):745–754. doi: 10.1002/1097-0142(197409)34:3<745::aid-cncr2820340333>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  14. Watanabe H., Enjoji M., Yao T., Iida M., Ohsato K. Accompanying gastro-enteric lesions in familial adenomatosis coli. Acta Pathol Jpn. 1977 Nov;27(6):823–839. doi: 10.1111/j.1440-1827.1977.tb03038.x. [DOI] [PubMed] [Google Scholar]
  15. Yao T., Ida M., Ohsato K., Watanabe H., Omae T. Duodenal lesions in familial polyposis of the colon. Gastroenterology. 1977 Nov;73(5):1086–1092. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES