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. 1987 Mar;28(3):315–318. doi: 10.1136/gut.28.3.315

Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissues.

A Bennett, A Civier, C N Hensby, P B Melhuish, I F Stamford
PMCID: PMC1432696  PMID: 3106172

Abstract

This is the first report of human gastrointestinal arachidonate and prostanoids measured quantitatively by gas chromatography-mass spectrometry (GC-MS) in extracts of human cancers and macroscopically normal tissues from the stomach and colon. There were microgram/g amounts of arachidonate, and the particularly high yield from the tumours may explain why they usually produce more prostaglandins than the normal tissues in which they arise. There was only a small conversion of the arachidonate into prostanoids. 6-Keto-PGF1 alpha was the most abundant metabolite measured, particularly in the tumour extracts, with smaller amounts of prostaglandins E2, F2 alpha and D2.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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