Skip to main content
Gut logoLink to Gut
. 1987 Jan;28(1):75–80. doi: 10.1136/gut.28.1.75

Penetration of albendazole sulphoxide into hydatid cysts.

D L Morris, J B Chinnery, G Georgiou, G Stamatakis, B Golematis
PMCID: PMC1432736  PMID: 3817589

Abstract

The penetration of albendazole sulphoxide, the principal metabolite of albendazole into hydatid cysts (E granulosus) was measured by means of in vitro animal and clinical studies. The drug freely diffuses across the parasitic membranes. Cyst/serum concentrations of 22% were achieved in patients, longer pre-operative therapy produced higher concentrations.

Full text

PDF
75

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bekhti A., Nizet M., Capron M., Dessaint J. P., Santoro F., Capron A. Chemotherapy of human hydatid disease with mebendazole. Follow-up of 16 cases. Acta Gastroenterol Belg. 1980 Jan-Feb;43(1-3):48–65. [PubMed] [Google Scholar]
  2. Bogan J. A., Marriner S. Analysis of benzimidazoles in body fluids by high-performance liquid chromatography. J Pharm Sci. 1980 Apr;69(4):422–423. doi: 10.1002/jps.2600690416. [DOI] [PubMed] [Google Scholar]
  3. Braithwaite P. A. Long-term high-dose mebendazole for cystic hydatid disease of liver: failure in two cases. Aust N Z J Surg. 1981 Feb;51(1):23–27. doi: 10.1111/j.1445-2197.1981.tb05897.x. [DOI] [PubMed] [Google Scholar]
  4. Braithwaite P. A., Roberts M. S., Allan R. J., Watson T. R. Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease. Eur J Clin Pharmacol. 1982;22(2):161–169. doi: 10.1007/BF00542462. [DOI] [PubMed] [Google Scholar]
  5. Bryceson A. D., Woestenborghs R., Michiels M., van den Bossche H. Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease. Trans R Soc Trop Med Hyg. 1982;76(4):563–564. doi: 10.1016/0035-9203(82)90163-8. [DOI] [PubMed] [Google Scholar]
  6. Kammerer W. S., Miller K. L. Echinococcus granulosus: permeability of hydatid cysts to mebendazole in mice. Int J Parasitol. 1981 Jun;11(3):183–185. doi: 10.1016/0020-7519(81)90046-1. [DOI] [PubMed] [Google Scholar]
  7. Marriner S. E., Morris D. L., Dickson B., Bogan J. A. Pharmacokinetics of albendazole in man. Eur J Clin Pharmacol. 1986;30(6):705–708. doi: 10.1007/BF00608219. [DOI] [PubMed] [Google Scholar]
  8. Morris D. L., Clarkson M. J., Stallbaumer M. F., Pritchard J., Jones R. S., Chinnery J. B. Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man. Thorax. 1985 Jun;40(6):453–458. doi: 10.1136/thx.40.6.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Morris D. L., Dykes P. W., Dickson B., Marriner S. E., Bogan J. A., Burrows F. G. Albendazole in hydatid disease. Br Med J (Clin Res Ed) 1983 Jan 8;286(6359):103–104. doi: 10.1136/bmj.286.6359.103-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Morris D. L., Dykes P. W., Marriner S., Bogan J., Burrows F., Skeene-Smith H., Clarkson M. J. Albendazole--objective evidence of response in human hydatid disease. JAMA. 1985 Apr 12;253(14):2053–2057. doi: 10.1001/jama.253.14.2053. [DOI] [PubMed] [Google Scholar]
  11. Morris D. L., Gould S. E. Serum and cyst concentrations of mebendazole and flubendazole in hydatid disease. Br Med J (Clin Res Ed) 1982 Jul 17;285(6336):175–175. doi: 10.1136/bmj.285.6336.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reisin I. L., Rabito C. A., Rotunno C. A., Cereijido M. The permeability of the membranes of experimental secondary cysts of Echinococcus granulosus to [14C]mebendazole. Int J Parasitol. 1977 Jun;7(3):189–194. doi: 10.1016/0020-7519(77)90045-5. [DOI] [PubMed] [Google Scholar]
  13. Saimot A. G., Meulemans A., Cremieux A. C., Giovanangeli M. D., Hay J. M., Delaitre B., Coulaud J. P. Albendazole as a potential treatment for human hydatidosis. Lancet. 1983 Sep 17;2(8351):652–656. doi: 10.1016/s0140-6736(83)92533-3. [DOI] [PubMed] [Google Scholar]
  14. Schantz P. M., Van den Bossche H., Eckert J. Chemotherapy for larval echinococcosis in animals and humans: report of a workshop. Z Parasitenkd. 1982;67(1):5–26. doi: 10.1007/BF00929509. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES