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. 1985 Jun;26(6):636–638. doi: 10.1136/gut.26.6.636

Ketoconazole-induced fulminant hepatitis.

E Bercoff, J Bernuau, C Degott, B Kalis, A Lemaire, H Tilly, B Rueff, J P Benhamou
PMCID: PMC1432772  PMID: 4007605

Abstract

We report the cases of two adult patients in whom fulminant hepatitis developed after 17 and 103 days of ketoconazole administration. Histologic administration showed massive, predominantly centrilobular necrosis. Clinical manifestations of hypersensitivity and eosinophilia were absent in both patients, which suggests that ketoconazole hepatotoxicity is not mediated through an immunoallergic mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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