Abstract
This study investigated whether ulcer prevention would be greater with the combined use of an acid-inhibiting agent, ranitidine, given together with a mucosal-protective agent, sucralphate. Duodenal ulcers were induced in rats with the secretagogues pentagastrin and bethanechol. Subtherapeutic doses of ranitidine (5 mg/kg/6 hours) and sucralphate (50 mg/6 hour) yielded an ulcer index of 4.0 and 4.1 respectively, not significantly different from the control (untreated) ulcer index of 4.3. Therapeutic doses of ranitidine (20 mg/kg) and sucralphate (200 mg/animal) gave an ulcer index of 0.4 and 0.5 respectively. Subtherapeutic doses of ranitidine and sucralphate given in combination yielded an ulcer index of 0.7. Thus, subtherapeutic doses of ranitidine and sucralphate given in combination had a synergistic effect equal to therapeutic doses of each of these drugs given alone. The therapeutic implications of combined acid inhibiting drugs with mucosal protective drugs is discussed.
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Selected References
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- Harrington S. J., Schlegel J. F., Code C. F. The protective effect of sucralfate on the gastric mucosa of rats. J Clin Gastroenterol. 1981;3(Suppl 2):129–134. [PubMed] [Google Scholar]
- Joffe S. N., Gaskin R. J., D'Sa A. A. Prevention of secretagogue-induced ulcers in the rat. Gastroenterology. 1976 May;70(5 PT1):751–752. [PubMed] [Google Scholar]
- Kaplan E., Barbezat G. O., Millner G. Studies with metiamide in the prevention of duodenal ulceration in the rat. Gastroenterology. 1976 Mar;70(3):475–476. [PubMed] [Google Scholar]
- Konturek S. J., Obtułowicz W., Kwiecień N., Kopp B., Oleksy J. Dynamics of gastric acid inhibition by ranitidine in duodenal ulcer patients. Digestion. 1981;22(3):119–125. doi: 10.1159/000198617. [DOI] [PubMed] [Google Scholar]
- Robert A., Stout T. J., Dale J. E. Production by secretagogues of duodenal ulcers in the rat. Gastroenterology. 1970 Jul;59(1):95–102. [PubMed] [Google Scholar]
- Szabo S. Duodenal ulcer disease. Animal model: cysteamine-induced acute and chronic duodenal ulcer in the rat. Am J Pathol. 1978 Oct;93(1):273–276. [PMC free article] [PubMed] [Google Scholar]