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. 1985 Aug;26(8):848–860. doi: 10.1136/gut.26.8.848

Natural history of the HBsAg carrier.

M G Anderson, I M Murray-Lyon
PMCID: PMC1432786  PMID: 3894172

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldershvile J., Dietrichson O., Skinhøj P., Kryger P., Mathiesen L. R., Christoffersen P., Nielsen J. O. Chronic persistent hepatitis: serological classification and meaning of the hepatitis B e system. Hepatology. 1982 Mar-Apr;2(2):243–246. doi: 10.1002/hep.1840020209. [DOI] [PubMed] [Google Scholar]
  2. Anderson K. E., Sun S. C., Berg H. S., Chang N. K. Liver function and histology in asymptomatic Chinese military personnel with hepatitis B antigenemia. Am J Dig Dis. 1974 Aug;19(8):693–703. doi: 10.1007/BF01844938. [DOI] [PubMed] [Google Scholar]
  3. Barker L. F., Murray R. Aquisition of hepatitis-associated antigen. Clinical features in young adults. JAMA. 1971 Jun 21;216(12):1970–1976. [PubMed] [Google Scholar]
  4. Barker L. F., Murray R. Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis--associated antigen. Am J Med Sci. 1972 Jan;263(1):27–33. doi: 10.1097/00000441-197201000-00005. [DOI] [PubMed] [Google Scholar]
  5. Beasley R. P., Hwang L. Y. Postnatal infectivity of hepatitis B surface antigen-carrier mothers. J Infect Dis. 1983 Feb;147(2):185–190. doi: 10.1093/infdis/147.2.185. [DOI] [PubMed] [Google Scholar]
  6. Beasley R. P., Shiao I. S., Wu T. C., Hwang L. Y. Hepatoma in an HBsAg carrier--seven years after perinatal infection. J Pediatr. 1982 Jul;101(1):83–84. doi: 10.1016/s0022-3476(82)80190-x. [DOI] [PubMed] [Google Scholar]
  7. Bernier R. H., Sampliner R., Gerety R., Tabor E., Hamilton F., Nathanson N. Hepatitis B infection in households of chronic carriers of hepatitis B surface antigen: factors associated with prevalence of infection. Am J Epidemiol. 1982 Aug;116(2):199–211. doi: 10.1093/oxfordjournals.aje.a113406. [DOI] [PubMed] [Google Scholar]
  8. Bonino F., Recchia S., Farci P., Actis G. C., Rizzetto M., Verme G., Gerin J. Hepatitis B virus replication and clinical outcome in carriers of HBsAg. Perspectives of treatment with DNA inhibitors. Liver. 1983 Feb;3(1):30–35. doi: 10.1111/j.1600-0676.1983.tb00847.x. [DOI] [PubMed] [Google Scholar]
  9. Bortolotti F., Cadrobbi P., Crivellaro C., Bertaggia A., Alberti A., Realdi G. Chronic hepatitis type B in childhood: longitudinal study of 35 cases. Gut. 1981 Jun;22(6):499–504. doi: 10.1136/gut.22.6.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bréchot C., Hadchouel M., Scotto J., Fonck M., Potet F., Vyas G. N., Tiollais P. State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3906–3910. doi: 10.1073/pnas.78.6.3906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cappel R., Van Beers D., Maes F., Toppet M., Cadranel S. Significance of persisting IgM anti-HBc antibodies in hepatitis B virus infection. J Med Virol. 1981;8(3):201–205. doi: 10.1002/jmv.1890080307. [DOI] [PubMed] [Google Scholar]
  12. Chadwick R. G., Galizzi J., Jr, Heathcote J., Lyssiotis T., Cohen B. J., Scheuer P. J., Sherlock S. Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up. Gut. 1979 May;20(5):372–377. doi: 10.1136/gut.20.5.372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Chau K. H., Hargie M. P., Decker R. H., Mushahwar I. K., Overby L. R. Serodiagnosis of recent hepatitis B infection by IgM class anti-HBc. Hepatology. 1983 Mar-Apr;3(2):142–149. doi: 10.1002/hep.1840030202. [DOI] [PubMed] [Google Scholar]
  14. Chevillotte G., Durbec J. P., Gerolami A., Berthezene P., Bidart J. M., Camatte R. Interaction between hepatitis b virus and alcohol consumption in liver cirrhosis. An epidemiologic study. Gastroenterology. 1983 Jul;85(1):141–145. [PubMed] [Google Scholar]
  15. Colombo M., Cambieri R., Rumi M. G., Ronchi G., Del Ninno E., De Franchis R. Long-term delta superinfection in hepatitis B surface antigen carriers and its relationship to the course of chronic hepatitis. Gastroenterology. 1983 Aug;85(2):235–239. [PubMed] [Google Scholar]
  16. Conteas C., Kao H., Rakela J., Weliky B. Acute type A hepatitis in three patients with chronic HBV infection. Dig Dis Sci. 1983 Aug;28(8):684–686. doi: 10.1007/BF01312556. [DOI] [PubMed] [Google Scholar]
  17. Craxi A., Weller I. V., Bassendine M. F., Fowler M. J., Monjardino J., Thomas H. C., Sherlock S. Relationship between HBV-specific DNA polymerase and HBe antigen/antibody system in chronic HBV infection: factors determining selection of patients and outcome of antiviral therapy. Gut. 1983 Feb;24(2):143–147. doi: 10.1136/gut.24.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Davis G. L., Hoofnagle J. H., Waggoner J. G. Spontaneous reactivation of chronic hepatitis B virus infection. Gastroenterology. 1984 Feb;86(2):230–235. [PubMed] [Google Scholar]
  19. De Franchis R., D'Arminio A., Vecchi M., Ronchi G., Del Ninno E., Parravicini A., Ferroni P., Zanetti A. R. Chronic asymptomatic HBSAg carriers: histologic abnormalities and diagnostic and prognostic value of serologic markers of the HBV. Gastroenterology. 1980 Sep;79(3):521–527. [PubMed] [Google Scholar]
  20. De Groote J., Fevery J., Lepoutre L. Long-term follow-up of chronic active hepatitis of moderate severity. Gut. 1978 Jun;19(6):510–513. doi: 10.1136/gut.19.6.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Dietrichson O. Chronic persistent hepatitis. A clinical, serological, and prognostic study. Scand J Gastroenterol. 1975;10(3):249–255. [PubMed] [Google Scholar]
  22. Dietzman D. E., Matthew E. B., Madden D. L., Sever J. L., Rostafinski M., Bouton S. M., Nagler B. The occurrence of epidemic infectious hepatitis in chronic carriers of Australia antigen. J Pediatr. 1972 Apr;80(4):577–582. doi: 10.1016/s0022-3476(72)80053-2. [DOI] [PubMed] [Google Scholar]
  23. Dormeyer H. H., Arnold W., Schönborn H., Braun B., Klinge O., Pfeifer U., Knolle J., Hess G., Kryger P., Nielsen J. O. The significance of serologic, histologic, and immunohistologic findings in the prognosis of 88 asymptomatic carriers of hepatitis B surface antigen. J Infect Dis. 1981 Jul;144(1):33–37. doi: 10.1093/infdis/144.1.33. [DOI] [PubMed] [Google Scholar]
  24. Dudley F. J., Scheuer P. J., Sherlock S. Natural history of hepatitis-associated antigen-positive chronic liver disease. Lancet. 1972 Dec 30;2(7792):1388–1393. doi: 10.1016/s0140-6736(72)92963-7. [DOI] [PubMed] [Google Scholar]
  25. Dusheiko G., Song E., Bowyer S., Whitcutt M., Maier G., Meyers A., Kew M. C. Natural history of hepatitis B virus infection in renal transplant recipients--a fifteen-year follow-up. Hepatology. 1983 May-Jun;3(3):330–336. doi: 10.1002/hep.1840030309. [DOI] [PubMed] [Google Scholar]
  26. Ellis W. R., Murray-Lyon I. M., Coleman J. C., Evans B. A., Fluker J. L., Bull J., Keeling P. W., Simmons P. D., Banatvala J. E., Willcox J. R. Liver disease among homosexual males. Lancet. 1979 Apr 28;1(8122):903–905. doi: 10.1016/s0140-6736(79)91376-x. [DOI] [PubMed] [Google Scholar]
  27. Farci P., Smedile A., Lavarini C., Piantino P., Crivelli O., Caporaso N., Toti M., Bonino F., Rizzetto M. Delta hepatitis in inapparent carriers of hepatitis B surface antigen. A disease simulating acute hepatitis B progressive to chronicity. Gastroenterology. 1983 Sep;85(3):669–673. [PubMed] [Google Scholar]
  28. Feinman S. V., Berris B., Cooter N., Sinclair J. C., Wrobel D. M. Results of long-term prospective study of the hepatitis B surface antigen (HBsAg) carrier state. Hepatogastroenterology. 1982 Apr;29(2):58–61. [PubMed] [Google Scholar]
  29. Feinman S. V., Overby L. R., Berris B., Chau K., Schable C. A., Maynard J. E. The significance of IgM antibodies to hepatitis B core antigen in hepatitis B carriers and hepatitis B-associated chronic liver disease. Hepatology. 1982 Nov-Dec;2(6):795–799. doi: 10.1002/hep.1840020609. [DOI] [PubMed] [Google Scholar]
  30. Francis D. P., Favero M. S., Maynard J. E. Transmission of hepatitis B virus. Semin Liver Dis. 1981 Feb;1(1):27–32. doi: 10.1055/s-2008-1063927. [DOI] [PubMed] [Google Scholar]
  31. Galbraith R. M., Eddleston A. L., Williams R., Zuckerman A. J. Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy. Lancet. 1975 Sep 20;2(7934):528–530. doi: 10.1016/s0140-6736(75)90897-1. [DOI] [PubMed] [Google Scholar]
  32. Gitnick G. Immunoglobulin M hepatitis B core antibody: to titer or not to titer? to use or not to use? Gastroenterology. 1983 Mar;84(3):653–655. [PubMed] [Google Scholar]
  33. Govindarajan S., Kanel G. C., Peters R. L. Prevalence of delta-antibody among chronic hepatitis B virus infected patients in the Los Angeles area: its correlation with liver biopsy diagnosis. Gastroenterology. 1983 Jul;85(1):160–162. [PubMed] [Google Scholar]
  34. Hadziyannis S. J. Chronic viral hepatitis. Clin Gastroenterol. 1974 May;3(2):391–408. [PubMed] [Google Scholar]
  35. Hadziyannis S. J., Lieberman H. M., Karvountzis G. G., Shafritz D. A. Analysis of liver disease, nuclear HBcAg, viral replication, and hepatitis B virus DNA in liver and serum of HBeAg Vs. anti-HBe positive carriers of hepatitis B virus. Hepatology. 1983 Sep-Oct;3(5):656–662. doi: 10.1002/hep.1840030505. [DOI] [PubMed] [Google Scholar]
  36. Hansson B. G., Moestrup T., Widell A., Nordenfelt E. Infection with delta agent in Sweden: introduction of a new hepatitis agent. J Infect Dis. 1982 Oct;146(4):472–478. doi: 10.1093/infdis/146.4.472. [DOI] [PubMed] [Google Scholar]
  37. Heyward W. L., Bender T. R., Lanier A. P., Francis D. P., McMahon B. J., Maynard J. E. Serological markers of hepatitis B virus and alpha-fetoprotein levels preceding primary hepatocellular carcinoma in Alaskan Eskimos. Lancet. 1982 Oct 23;2(8304):889–891. doi: 10.1016/s0140-6736(82)90863-7. [DOI] [PubMed] [Google Scholar]
  38. Hoofnagle J. H., Dusheiko G. M., Schafer D. F., Jones E. A., Micetich K. C., Young R. C., Costa J. Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. Ann Intern Med. 1982 Apr;96(4):447–449. doi: 10.7326/0003-4819-96-4-447. [DOI] [PubMed] [Google Scholar]
  39. Hoofnagle J. H., Dusheiko G. M., Seeff L. B., Jones E. A., Waggoner J. G., Bales Z. B. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med. 1981 Jun;94(6):744–748. doi: 10.7326/0003-4819-94-6-744. [DOI] [PubMed] [Google Scholar]
  40. Hoofnagle J. H., Hanson R. G., Minuk G. Y., Pappas S. C., Schafer D. F., Dusheiko G. M., Straus S. E., Popper H., Jones E. A. Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis. Gastroenterology. 1984 Jan;86(1):150–157. [PubMed] [Google Scholar]
  41. Hoofnagle J. H. Type B hepatitis: virology, serology and clinical course. Semin Liver Dis. 1981 Feb;1(1):7–14. doi: 10.1055/s-2008-1063925. [DOI] [PubMed] [Google Scholar]
  42. Karayiannis P., Fowler M. J., Lok A. S., Greenfield C., Monjardino J., Thomas H. C. Detection of serum HBV-DNA by molecular hybridisation. Correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma. J Hepatol. 1985;1(2):99–106. doi: 10.1016/s0168-8278(85)80759-5. [DOI] [PubMed] [Google Scholar]
  43. Koff R. S. Management of the hepatitis B surface antigen (HBsAg) carrier. Semin Liver Dis. 1981 Feb;1(1):33–43. doi: 10.1055/s-2008-1063928. [DOI] [PubMed] [Google Scholar]
  44. Koretz R. L., Lewin K. J., Rebhun D. J., Gitnick G. L. Hepatitis B surface antigen carriers--to biopsy or not to biopsy. Gastroenterology. 1978 Nov;75(5):860–863. [PubMed] [Google Scholar]
  45. Kornfeld H., Vande Stouwe R. A., Lange M., Reddy M. M., Grieco M. H. T-lymphocyte subpopulations in homosexual men. N Engl J Med. 1982 Sep 16;307(12):729–731. doi: 10.1056/NEJM198209163071206. [DOI] [PubMed] [Google Scholar]
  46. Lam K. C., Lai C. L., Trepo C., Wu P. C. Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis. N Engl J Med. 1981 Feb 12;304(7):380–386. doi: 10.1056/NEJM198102123040702. [DOI] [PubMed] [Google Scholar]
  47. Lemon S. M., Gates N. L., Simms T. E., Bancroft W. H. IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J Infect Dis. 1981 Jun;143(6):803–809. doi: 10.1093/infdis/143.6.803. [DOI] [PubMed] [Google Scholar]
  48. Liaw Y. F., Chu C. M., Chen T. J., Lin D. Y., Chang-Chien C. S., Wu C. S. Chronic lobular hepatitis: a clinicopathological and prognostic study. Hepatology. 1982 Mar-Apr;2(2):258–262. doi: 10.1002/hep.1840020213. [DOI] [PubMed] [Google Scholar]
  49. Liaw Y. F., Chu C. M., Su I. J., Huang M. J., Lin D. Y., Chang-Chien C. S. Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology. 1983 Feb;84(2):216–219. [PubMed] [Google Scholar]
  50. Liaw Y. F., Sheen I. S., Chu C. M., Chen T. J. Chronic hepatitis with nonspecific histological changes. Is it a distinct variant of chronic hepatitis? Liver. 1984 Feb;4(1):55–60. doi: 10.1111/j.1600-0676.1984.tb00908.x. [DOI] [PubMed] [Google Scholar]
  51. Liaw Y. F., Sung J. L. Liver biopsy in asymptomatic carriers of HBsAg. Gastroenterology. 1979 May;76(5 Pt 1):1084–1084. [PubMed] [Google Scholar]
  52. Lieberman H. M., LaBrecque D. R., Kew M. C., Hadziyannis S. J., Shafritz D. A. Detection of hepatitis B virus DNA directly in human serum by a simplified molecular hybridization test: comparison to HBeAg/anti-HBe status in HBsAg carriers. Hepatology. 1983 May-Jun;3(3):285–291. doi: 10.1002/hep.1840030302. [DOI] [PubMed] [Google Scholar]
  53. Lightdale C. J., Ikram H., Pinsky C. Primary hepatocellular carcinoma with hepatitis B antigenemia: effects of chemotherapy. Cancer. 1980 Sep 1;46(5):1117–1122. doi: 10.1002/1097-0142(19800901)46:5<1117::aid-cncr2820460507>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  54. Lo K. J., Tong M. J., Chien M. C., Tsai Y. T., Liaw Y. F., Yang K. C., Chian H., Liu H. C., Lee S. D. The natural course of hepatitis B surface antigen-positive chronic active hepatitis in Taiwan. J Infect Dis. 1982 Aug;146(2):205–210. doi: 10.1093/infdis/146.2.205. [DOI] [PubMed] [Google Scholar]
  55. Maupas P., Chiron J. P., Barin F., Coursaget P., Goudeau A., Perrin J., Denis F., Mar I. D. Efficacy of hepatitis B vaccine in prevention of early HBsAg carrier state in children. Controlled trial in an endemic area (Senegal). Lancet. 1981 Feb 7;1(8215):289–292. doi: 10.1016/s0140-6736(81)91908-5. [DOI] [PubMed] [Google Scholar]
  56. Moestrup T., Hansson B. G., Widell A., Nordenfelt E. Clinical aspects of delta infection. Br Med J (Clin Res Ed) 1983 Jan 8;286(6359):87–90. doi: 10.1136/bmj.286.6359.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Mondelli M., Eddleston A. L. Mechanisms of liver cell injury in acute and chronic hepatitis B. Semin Liver Dis. 1984 Feb;4(1):47–58. doi: 10.1055/s-2008-1040645. [DOI] [PubMed] [Google Scholar]
  58. Nielsen J. O., Dietrichson O., Elling P., Christoffersen P. Incidence and meaning of persistence of Australia antigen in patients with acute viral hepatitis: development of chronic hepatitis. N Engl J Med. 1971 Nov 18;285(21):1157–1160. doi: 10.1056/NEJM197111182852101. [DOI] [PubMed] [Google Scholar]
  59. Norkrans G., Lindberg J., Frösner G., Hermodsson S., Lundin P., Iwarson S. Clearance of hepatitis B e-antigen in chronic hepatitis B infection. Scand J Gastroenterol. 1982 Apr;17(3):383–387. doi: 10.3109/00365528209182072. [DOI] [PubMed] [Google Scholar]
  60. Obata H., Hayashi N., Motoike Y., Hisamitsu T., Okuda H., Kobayashi S., Nishioka K. A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection. Int J Cancer. 1980 Jun 15;25(6):741–747. doi: 10.1002/ijc.2910250609. [DOI] [PubMed] [Google Scholar]
  61. Ohnishi K., Iida S., Iwama S., Goto N., Nomura F., Takashi M., Mishima A., Kono K., Kimura K., Musha H. The effect of chronic habitual alcohol intake on the development of liver cirrhosis and hepatocellular carcinoma: relation to hepatitis B surface antigen carriage. Cancer. 1982 Feb 15;49(4):672–677. doi: 10.1002/1097-0142(19820215)49:4<672::aid-cncr2820490415>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  62. Omata M., Afroudakis A., Liew C. T., Ashcavai M., Peters R. L. Comparison of serum hepatitis B surface antigen (HBsAg) and serum anticore with tissue HBsAg and hepatitis B core antigen (HBcAg). Gastroenterology. 1978 Dec;75(6):1003–1009. [PubMed] [Google Scholar]
  63. Omata M., Ashcavai M., Liew C. T., Peters R. L. Hepatocellular carcinoma in the U.S.A., etiologic considerations. Localization of hepatitis B antigens. Gastroenterology. 1979 Feb;76(2):279–287. [PubMed] [Google Scholar]
  64. Paradinas F. J., Davies D. R., Supran E. M., Viola L., Marigold J. H. Histopathology and localization of viral antigens in the liver of HBsAg positive homosexuals. Histopathology. 1981 Nov;5(6):623–637. doi: 10.1111/j.1365-2559.1981.tb01829.x. [DOI] [PubMed] [Google Scholar]
  65. Perrillo R. P., Aach R. D. The clinical course and chronic sequelae of hepatitis B virus infection. Semin Liver Dis. 1981 Feb;1(1):15–25. doi: 10.1055/s-2008-1063926. [DOI] [PubMed] [Google Scholar]
  66. Perrillo R. P., Chau K. H., Overby L. R., Decker R. H. Anti-hepatitis B core immunoglobulin M in the serologic evaluation of hepatitis B virus infection and simultaneous infection with type B, delta agent, and non-A, non-B viruses. Gastroenterology. 1983 Jul;85(1):163–167. [PubMed] [Google Scholar]
  67. Popper H., Thung S. N., Gerber M. A., Hadler S. C., de Monzon M., Ponzetto A., Anzola E., Rivera D., Mondolfi A., Bracho A. Histologic studies of severe delta agent infection in Venezuelan Indians. Hepatology. 1983 Nov-Dec;3(6):906–912. doi: 10.1002/hep.1840030603. [DOI] [PubMed] [Google Scholar]
  68. Raimondo G., Recchia S., Lavarini C., Crivelli O., Rizzetto M. Dane particle-associated hepatitis B e antigen in patients with chronic hepatitis B virus infection and hepatitis B e antibody. Hepatology. 1982 Jul-Aug;2(4):449–454. doi: 10.1002/hep.1840020410. [DOI] [PubMed] [Google Scholar]
  69. Raimondo G., Smedile A., Gallo L., Balbo A., Ponzetto A., Rizzetto M. Multicentre study of prevalence of HBV-associated delta infection and liver disease in drug-addicts. Lancet. 1982 Jan 30;1(8266):249–251. doi: 10.1016/s0140-6736(82)90976-x. [DOI] [PubMed] [Google Scholar]
  70. Ray M. B., Desmet V. J., Fevery J., De Groote J., Bradburne A. F., Desmyter J. Hepatitis B surface antigen (HBsAg) in the liver of patients with hepatitis; a comparison with serological detection. J Clin Pathol. 1976 Feb;29(2):89–93. doi: 10.1136/jcp.29.2.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Realdi G., Alberti A., Rugge M., Bortolotti F., Rigoli A. M., Tremolada F., Ruol A. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gastroenterology. 1980 Aug;79(2):195–199. [PubMed] [Google Scholar]
  72. Reesink H. W., Wesdorp I. C., Grijm R., Hengeveld P., Jöbsis A. C., Aay C., Reerink-Brongers E. E. Follow-up of blood donors positive for hepatitis B surface antigen. Vox Sang. 1980;38(3):138–146. doi: 10.1111/j.1423-0410.1980.tb02341.x. [DOI] [PubMed] [Google Scholar]
  73. Regenstein F. G., Roodman S. T., Perrillo R. P. Immunoregulatory T cell subsets in chronic hepatitis B virus infection: the influence of homosexuality. Hepatology. 1983 Nov-Dec;3(6):951–954. doi: 10.1002/hep.1840030612. [DOI] [PubMed] [Google Scholar]
  74. Reinicke V., Dybkjaer E., Poulsen H., Banke O., Lylloff K., Nordenfelt E. A study of Australia-antigen-positive blood donors and their recipients, with special reference to liver histology. N Engl J Med. 1972 Apr 20;286(16):867–870. doi: 10.1056/NEJM197204202861604. [DOI] [PubMed] [Google Scholar]
  75. Rizzetto M., Canese M. G., Gerin J. L., London W. T., Sly D. L., Purcell R. H. Transmission of the hepatitis B virus-associated delta antigen to chimpanzees. J Infect Dis. 1980 May;141(5):590–602. doi: 10.1093/infdis/141.5.590. [DOI] [PubMed] [Google Scholar]
  76. Rizzetto M., Shih J. W., Gocke D. J., Purcell R. H., Verme G., Gerin J. L. Incidence and significance of antibodies to delta antigen in hepatitis B virus infection. Lancet. 1979 Nov 10;2(8150):986–990. doi: 10.1016/s0140-6736(79)92561-3. [DOI] [PubMed] [Google Scholar]
  77. Rizzetto M., Verme G., Recchia S., Bonino F., Farci P., Aricò S., Calzia R., Picciotto A., Colombo M., Popper H. Chronic hepatitis in carriers of hepatitis B surface antigen, with intrahepatic expression of the delta antigen. An active and progressive disease unresponsive to immunosuppressive treatment. Ann Intern Med. 1983 Apr;98(4):437–441. doi: 10.7326/0003-4819-98-4-437. [DOI] [PubMed] [Google Scholar]
  78. Sagnelli E., Manzillo G., Maio G., Pasquale G., Felaco F. M., Filippini P., Izzo C. M., Piccinino F. Serum levels of hepatitis B surface and core antigens during immunosuppressive treatment of HBsAg-positive chronic active hepatitis. Lancet. 1980 Aug 23;2(8191):395–397. doi: 10.1016/s0140-6736(80)90442-0. [DOI] [PubMed] [Google Scholar]
  79. Sakuma K., Takahara T., Okuda K., Tsuda F., Mayumi M. Prognosis of hepatitis B virus surface antigen carriers in relation to routine liver function tests: a prospective study. Gastroenterology. 1982 Jul;83(1 Pt 1):114–117. [PubMed] [Google Scholar]
  80. Sampliner R. E., Hamilton F. A., Iseri O. A., Tabor E., Boitnott J. The liver histology and frequency of clearance of the hepatitis B surface antigen (HBsAg) in chronic carriers. Am J Med Sci. 1979 Jan-Feb;277(1):17–22. doi: 10.1097/00000441-197901000-00002. [DOI] [PubMed] [Google Scholar]
  81. Sampliner R. E. The duration of hepatitis B surface antigenemia. Arch Intern Med. 1979 Feb;139(2):145–146. [PubMed] [Google Scholar]
  82. Schreeder M. T., Thompson S. E., Hadler S. C., Berquist K. R., Zaidi A., Maynard J. E., Ostrow D., Judson F. N., Braff E. H., Nylund T. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982 Jul;146(1):7–15. doi: 10.1093/infdis/146.1.7. [DOI] [PubMed] [Google Scholar]
  83. Schulman A. N., Fagen N. D., Brezina M., Silver H., Nitzze A., Morton D., Gitnick G. L. HBe-Antigen in the course and prognosis of hepatitis B infection: a prospective study. Gastroenterology. 1980 Feb;78(2):253–258. [PubMed] [Google Scholar]
  84. Scullard G. H., Smith C. I., Merigan T. C., Robinson W. S., Gregory P. B. Effects of immunosuppressive therapy on viral markers in chronic active hepatitis B. Gastroenterology. 1981 Dec;81(6):987–991. [PubMed] [Google Scholar]
  85. Shafritz D. A., Shouval D., Sherman H. I., Hadziyannis S. J., Kew M. C. Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens. N Engl J Med. 1981 Oct 29;305(18):1067–1073. doi: 10.1056/NEJM198110293051807. [DOI] [PubMed] [Google Scholar]
  86. Shafritz D. A., Shouval D., Zern M. A. Recombinant DNA and the liver: studies with albumin, alpha-fetoprotein, hepatitis B virus, and other DNA probes. Prog Liver Dis. 1982;7:429–449. [PubMed] [Google Scholar]
  87. Shikata T., Karasawa T., Abe K., Uzawa T., Suzuki H., Oda T., Imai M., Mayumi M., Moritsugu Y. Hepatitis B e antigen and infectivity of hepatitis B virus. J Infect Dis. 1977 Oct;136(4):571–576. doi: 10.1093/infdis/136.4.571. [DOI] [PubMed] [Google Scholar]
  88. Shrago S. S., Auslander M. O., Gitnick G. L. Hepatic pathologic condition in asymptomatic Australia antigen carriers. A light microscopical study of 26 cases and a review of the literature. Arch Pathol Lab Med. 1977 Dec;101(12):648–651. [PubMed] [Google Scholar]
  89. Singleton J. W., Merrill D. A., Fitch R. A., Kohler P. F., Rettberg W. A. Liver disease in Australia-antigen-positive blood-donors. Lancet. 1971 Oct 9;2(7728):785–787. doi: 10.1016/s0140-6736(71)92740-1. [DOI] [PubMed] [Google Scholar]
  90. Smedile A., Dentico P., Zanetti A., Sagnelli E., Nordenfelt E., Actis G. C., Rizzetto M. Infection with the delta agent in chronic HBsAg carriers. Gastroenterology. 1981 Dec;81(6):992–997. [PubMed] [Google Scholar]
  91. Smedile A., Farci P., Verme G., Caredda F., Cargnel A., Caporaso N., Dentico P., Trepo C., Opolon P., Gimson A. Influence of delta infection on severity of hepatitis B. Lancet. 1982 Oct 30;2(8305):945–947. doi: 10.1016/s0140-6736(82)90156-8. [DOI] [PubMed] [Google Scholar]
  92. Smith C. I., Merigan T. C. Therapeutic approaches to chronic hepatitis B. Prog Liver Dis. 1982;7:481–494. [PubMed] [Google Scholar]
  93. Sun S., Beasley R. P., Anderson K. E., Berg H. S., Hsu C., Lee W. Serial liver biopsy observations in hepatitis B antigen carriers by light and electron microscopy. Am J Dig Dis. 1976 May;21(6):366–369. doi: 10.1007/BF01072657. [DOI] [PubMed] [Google Scholar]
  94. Tapp E., Jones D. M., Hollanders D., Dymock I. W. Serial liver biopsies in blood donors with persistent HBs antigenaemia. J Clin Pathol. 1976 Oct;29(10):884–886. doi: 10.1136/jcp.29.10.884. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Theodossi A., Wilkinson S. P., Portmann B., White Y., Eddleston A. L., Williams R., Zuckerman A. J. De novo acute infection and reactivation of hepatitis B virus in established cirrhosis. Br Med J. 1979 Oct 13;2(6195):893–895. doi: 10.1136/bmj.2.6195.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Tong M. J., Stevenson D., Gordon I. Correlation of e antigen, DNA polymerase activity, and Dane particles in chronic benign and chronic active type B hepatitis infections. J Infect Dis. 1977 Jun;135(6):980–984. doi: 10.1093/infdis/135.6.980. [DOI] [PubMed] [Google Scholar]
  97. Van Waes L., Segers J., Van Egmond J., Van Nimmen L., Barbier F., Wieme R., Demeulenaere L. Chronic liver disease and hepatitis-B antigen: a prospective study. Br Med J. 1974 Aug 17;3(5928):444–446. doi: 10.1136/bmj.3.5928.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Velasco M., González-Cerón M., de la Fuente C., Ruiz A., Donoso S., Katz R. Clinical and pathological study of asymptomatic HBsAg carriers in Chile. Gut. 1978 Jun;19(6):569–571. doi: 10.1136/gut.19.6.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Villa E., Rubbiani L., Barchi T., Ferretti I., Grisendi A., De Palma M., Bellentani S., Manenti F. Susceptibility of chronic symptomless HBsAg carriers to ethanol-induced hepatic damage. Lancet. 1982 Dec 4;2(8310):1243–1244. doi: 10.1016/s0140-6736(82)90104-0. [DOI] [PubMed] [Google Scholar]
  100. Villeneuve J. P., Richer G., Côté J., Guévin R., Marleau D., Joly J. G., Viallet A. Chronic carriers of hepatitis B antigen (HBsAg). Histological, biochemical, and immunological findings in 31 voluntary blood donors. Am J Dig Dis. 1976 Jan;21(1):18–25. doi: 10.1007/BF01074134. [DOI] [PubMed] [Google Scholar]
  101. Viola L. A., Barrison I. G., Coleman J. C., Murray-Lyon I. M. The clinical course of acute type A hepatitis in chronic HBsAg carriers--a report of 3 cases. Postgrad Med J. 1982 Feb;58(676):80–81. doi: 10.1136/pgmj.58.676.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Viola L. A., Barrison I. G., Coleman J. C., Paradinas F. J., Fluker J. L., Evans B. A., Murray-Lyon I. M. Natural history of liver disease in chronic hepatitis B surface antigen carriers. Survey of 100 patients from Great Britain. Lancet. 1981 Nov 21;2(8256):1156–1159. doi: 10.1016/s0140-6736(81)90600-0. [DOI] [PubMed] [Google Scholar]
  103. Viola L. A., Barrison I. G., Coleman J. C., Paradinas F. J., Murray-Lyon I. M. The HBe antigen-antibody system and its relationship to clinical and laboratory findings in 100 chronic HBsAg carriers in Great Britain. J Med Virol. 1981;8(3):169–175. doi: 10.1002/jmv.1890080303. [DOI] [PubMed] [Google Scholar]
  104. Vittal S. B., Dourdourekas D., Shobassy N., Gerber M., Telischi M., Szanto P. B., Steigmann F., Clowdus B. F. Asymptomatic hapatic disease in blood donors with hepatitis B antigenemia. Am J Clin Pathol. 1974 Nov;62(5):649–654. doi: 10.1093/ajcp/62.5.649. [DOI] [PubMed] [Google Scholar]
  105. Weller I. V., Bassendine M. F., Murray A. K., Craxi A., Thomas H. C., Sherlock S. Effects of prednisolone/azathioprine in chronic hepatitis B viral infection. Gut. 1982 Aug;23(8):650–655. doi: 10.1136/gut.23.8.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Weller I. V., Fowler M. J., Monjardino J., Thomas H. C. The detection of HBV-DNA in serum by molecular hybridisation: a more sensitive method for the detection of complete HBV particles. J Med Virol. 1982;9(4):273–280. doi: 10.1002/jmv.1890090405. [DOI] [PubMed] [Google Scholar]
  107. Weller I. V., Karayiannis P., Lok A. S., Montano L., Bamber M., Thomas H. C., Sherlock S. Significance of delta agent infection in chronic hepatitis B virus infection: a study in British carriers. Gut. 1983 Nov;24(11):1061–1063. doi: 10.1136/gut.24.11.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Whittle H. C., Bradley A. K., McLauchlan K., Ajdukiewicz A. B., Howard C. R., Zuckerman A. J., McGregor I. A. Hepatitis B virus infection in two Gambian villages. Lancet. 1983 May 28;1(8335):1203–1206. doi: 10.1016/s0140-6736(83)92477-7. [DOI] [PubMed] [Google Scholar]
  109. Wilkinson S. P., Portmann B., Cochrane A. M., Tee D. E., Williams R. Clinical course of chronic lobular hepatitis: report of five cases. Q J Med. 1978 Oct;47(188):421–429. [PubMed] [Google Scholar]
  110. Woolf I. L., Boyes B. E., Jones D. M., Whittaker J. S., Tapp E., MacSween R. N., Renton P. H., Stratton F., Dymock I. W. Asymptomatic liver disease in hepatitis B antigen carriers. J Clin Pathol. 1974 May;27(5):348–352. doi: 10.1136/jcp.27.5.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Zachoval R., Roggendorf M., Deinhardt F. Hepatitis A infection in chronic carriers of hepatitis B virus. Hepatology. 1983 Jul-Aug;3(4):528–531. doi: 10.1002/hep.1840030409. [DOI] [PubMed] [Google Scholar]

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