Skip to main content
Gut logoLink to Gut
. 1985 Aug;26(8):822–824. doi: 10.1136/gut.26.8.822

Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis.

P B McIntyre, F A Macrae, L Berghouse, J English, J E Lennard-Jones
PMCID: PMC1432788  PMID: 3894171

Abstract

A double blind controlled trial has been conducted in 40 patients to compare the therapeutic effects of prednisolone metasulphobenzoate enemas with those of prednisolone-21-phosphate enemas. Both enemas brought about improvement in symptoms and sigmoidoscopic appearances in more than 70% of patients treated. The absorption of prednisolone from the metasulphobenzoate enema in three patients was less than from the 21-phosphate enema. In view of the low plasma prednisolone concentrations obtained, there are theoretical advantages in using a poorly absorbed enema to avoid the possibility of systemic steroid effects in patients requiring long term steroid treatment.

Full text

PDF
822

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chakraborty J., English J., Marks V., Dumasia M. C., Chapman D. J. A radioimmunoassay method for prednisolone: comparison with the competitive protein binding method. Br J Clin Pharmacol. 1976 Oct;3(5):903–906. doi: 10.1111/j.1365-2125.1976.tb00645.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Lee D. A., Taylor G. M., James V. H., Walker G. Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema. Gut. 1979 May;20(5):349–355. doi: 10.1136/gut.20.5.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lee D. A., Taylor M., James V. H., Walker G. Rectally administered prednisolone--evidence for a predominantly local action. Gut. 1980 Mar;21(3):215–218. doi: 10.1136/gut.21.3.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MATTS S. G. Intrarectal treatment of 100 cases of ulcerative colitis with prednisolone-21-phosphate enemata. Br Med J. 1961 Jan 21;1(5220):165–168. doi: 10.1136/bmj.1.5220.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Powell-Tuck J., Lennard-Jones J. E., May C. S., Wilson C. G., Paterson J. W. Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. Br Med J. 1976 Jan 24;1(6003):193–195. doi: 10.1136/bmj.1.6003.193. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES