Abstract
Because the normal faecal flora includes bacteria which can produce mucus-digesting glycosidases, it follows that increased digestion of colonic mucus by these bacterial enzymes could be important in the pathogenesis of ulcerative colitis. Faecal activities of potential mucus-degrading glycosidases have therefore been assayed in samples from patients with inflammatory bowel disease and normal controls. The enzymes alpha-D-galactosidase, beta-D-galactosidase, beta-NAc-D-glucosaminidase alpha-L-fucosidase and neuraminidase were assayed. Considerable glycosidase activity was present in most faecal samples. Similar activities of all the enzymes assayed were found in faeces from patients with ulcerative colitis, Crohn's disease and normal controls and there was no significant correlation with disease activity. These results imply that relapse of ulcerative colitis is not initiated by increased degradation of colonic mucus by faecal glycosidases but do not exclude a role for bacterial mucus degradation in the pathogenesis of ulcerative colitis.
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Selected References
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- De Dombal F. T., Burton I., Goligher J. C. The early and late results of surgical treatment for Crohn's disease. Br J Surg. 1971 Nov;58(11):805–816. doi: 10.1002/bjs.1800581102. [DOI] [PubMed] [Google Scholar]
- Hoskins L. C., Boulding E. T. Mucin degradation in human colon ecosystems. Evidence for the existence and role of bacterial subpopulations producing glycosidases as extracellular enzymes. J Clin Invest. 1981 Jan;67(1):163–172. doi: 10.1172/JCI110009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kane S. P., Vincenti A. C. Mucosal enzymes in human inflammatory bowel disease with reference to neutrophil granulocytes as mediators of tissue injury. Clin Sci (Lond) 1979 Oct;57(4):295–303. doi: 10.1042/cs0570295. [DOI] [PubMed] [Google Scholar]
- Miller R. S., Hoskins L. C. Mucin degradation in human colon ecosystems. Fecal population densities of mucin-degrading bacteria estimated by a "most probable number" method. Gastroenterology. 1981 Oct;81(4):759–765. [PubMed] [Google Scholar]
- Podolsky D. K., Isselbacher K. J. Composition of human colonic mucin. Selective alteration in inflammatory bowel disease. J Clin Invest. 1983 Jul;72(1):142–153. doi: 10.1172/JCI110952. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prizont R., Konigsberg N. Identification of bacterial glycosidases in rat cecal contents. Dig Dis Sci. 1981 Sep;26(9):773–777. doi: 10.1007/BF01309607. [DOI] [PubMed] [Google Scholar]
- TRUELOVE S. C., WITTS L. J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955 Oct 29;2(4947):1041–1048. doi: 10.1136/bmj.2.4947.1041. [DOI] [PMC free article] [PubMed] [Google Scholar]