Abstract
We describe a patient with intestinal lymphangiectasia who developed hyposplenism and speculate that it resulted from chronic loss of lymphocytes into the gut.
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Selected References
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- Bullen A. W., Losowsky M. S. Lymphocyte subpopulations in adult coeliac disease. Gut. 1978 Oct;19(10):892–897. doi: 10.1136/gut.19.10.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CROSBY W. H. Hyposplenism: an inquiry into normal functions of the spleen. Annu Rev Med. 1963;14:349–370. doi: 10.1146/annurev.me.14.020163.002025. [DOI] [PubMed] [Google Scholar]
- Corazza G. R., Bullen A. W., Hall R., Robinson P. J., Losowsky M. S. Simple method of assessing splenic function in coeliac disease. Clin Sci (Lond) 1981 Jan;60(1):109–113. doi: 10.1042/cs0600109. [DOI] [PubMed] [Google Scholar]
- Fish J. C., Beathard G., Sarles H. E., Remmers A. R., Jr, Ritzmann S. E. Circulating lymphocyte depletion: effect on lymphoid tissue. Surgery. 1970 Apr;67(4):658–666. [PubMed] [Google Scholar]
- Kenny M. W., George A. J., Stuart J. Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism. J Clin Pathol. 1980 Jul;33(7):622–625. doi: 10.1136/jcp.33.7.622. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LIPSON R. L., BAYRD E. D., WATKINS C. H. The postsplenectomy blood picture. Am J Clin Pathol. 1959 Dec;32:526–532. doi: 10.1093/ajcp/32.6.526. [DOI] [PubMed] [Google Scholar]
- Lockwood C. M., Worlledge S., Nicholas A., Cotton C., Peters D. K. Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N Engl J Med. 1979 Mar 8;300(10):524–530. doi: 10.1056/NEJM197903083001003. [DOI] [PubMed] [Google Scholar]
- Marsh G. W., Lewis S. M., Szur L. The use of 51Cr-labelled heat-damaged red cells to study splenic function. II. Splenic atrophy in thrombocythaemia. Br J Haematol. 1966 Mar;12(2):167–171. doi: 10.1111/j.1365-2141.1966.tb05621.x. [DOI] [PubMed] [Google Scholar]
- Morowitz D. A., Allen L. W., Kirsner J. B. Thrombocytosis in chronic inflammatory bowel disease. Ann Intern Med. 1968 May;68(5):1013–1021. doi: 10.7326/0003-4819-68-5-1013. [DOI] [PubMed] [Google Scholar]
- Palmer K. R., Sherriff S. B., Holdsworth C. D., Ryan F. P. Further experience of hyposplenism in inflammatory bowel disease. Q J Med. 1981 Autumn;50(200):463–471. [PubMed] [Google Scholar]
- Pearson H. A., Johnston D., Smith K. A., Touloukian R. J. The born-again spleen. Return of splenic function after splenectomy for trauma. N Engl J Med. 1978 Jun 22;298(25):1389–1392. doi: 10.1056/NEJM197806222982504. [DOI] [PubMed] [Google Scholar]
- Roberts S. H., Douglas A. P. Intestinal lymphangiectasia: the variability of presentation. A study of five cases. Q J Med. 1976 Jan;45(177):39–48. [PubMed] [Google Scholar]
- Ryan F. P., Smart R. C., Holdsworth C. D., Preston F. E. Hyposplenism in inflammatory bowel disease. Gut. 1978 Jan;19(1):50–55. doi: 10.1136/gut.19.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Selroos O. Thrombocytosis. Acta Med Scand. 1973 May;193(5):431–436. doi: 10.1111/j.0954-6820.1973.tb10605.x. [DOI] [PubMed] [Google Scholar]
- Strober W., Wochner R. D., Carbone P. P., Waldmann T. A. Intestinal lymphangiectasia: a protein-losing enteropathy with hypogammaglobulinemia, lymphocytopenia and impaired homograft rejection. J Clin Invest. 1967 Oct;46(10):1643–1656. doi: 10.1172/JCI105656. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ward M., Le Roux A., Small W. P., Sircus W. Malignant lymphoma and extensive viral wart formation in a patient with intestinal lymphangiectasia and lymphocyte depletion. Postgrad Med J. 1977 Dec;53(626):753–757. doi: 10.1136/pgmj.53.626.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weiden P. L., Blaese R. M., Strober W., Block J. B., Waldmann T. A. Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man. J Clin Invest. 1972 Jun;51(6):1319–1325. doi: 10.1172/JCI106928. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams B. D., Pussell B. A., Lockwood C. M., Cotton C. Defective reticuloendothelial system function in rheumatoid arthritis. Lancet. 1979 Jun 23;1(8130):1311–1314. doi: 10.1016/s0140-6736(79)91947-0. [DOI] [PubMed] [Google Scholar]
