Abstract
After healing of a gastric ulcer, 53 patients were randomly allocated to either 12 months maintenance treatment with ranitidine 150 mg at night or an identical placebo. Fifty patients completed the trial. The patients were interviewed every third month. If symptoms indicated a relapse, endoscopy was done; and if an ulcer was found the maintenance trial was terminated. All remaining patients were endoscoped after one year. The accumulated relapse rate in the ranitidine group (36%) was significantly lower (p less than 0.01) than in the placebo group (76%), as also was the antacid consumption (p less than 0.01). Four of the six ulcers found at the final one year endoscopy were asymptomatic. In all but two of the 26 patients with relapse of symptoms an ulcer was found at endoscopy. The patients that suffered a recurrence had significantly (p less than 0.05) higher maximal acid output than those without ulcer recurrence. The time needed for healing of the relapse ulcers (four or eight weeks) corresponded to that needed for healing of the preinclusion ulcers. It is concluded that ranitidine 150 mg at night significantly reduces the gastric ulcer recurrence rate, and that relapsing ulcers are similar to the initial ones in healing response.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baron J. H., Perrin V. L. Gastric ulcer healing with ranitidine and cimetidine. A multicentre study. Scand J Gastroenterol. 1983 Oct;18(7):973–976. doi: 10.3109/00365528309182125. [DOI] [PubMed] [Google Scholar]
- Barr G. D., Kang J. Y., Canalese J., Piper D. W. A two-year prospective controlled study of maintenance cimetidine and gastric ulcer. Gastroenterology. 1983 Jul;85(1):100–104. [PubMed] [Google Scholar]
- Boyd E. J., Wilson J. A., Wormsley K. G. Safety of ranitidine maintenance treatment of duodenal ulcer. Scand J Gastroenterol. 1984 May;19(3):394–400. [PubMed] [Google Scholar]
- Gough K. R., Korman M. G., Bardhan K. D., Lee F. I., Crowe J. P., Reed P. I., Smith R. N. Ranitidine and cimetidine in prevention of duodenal ulcer relapse. A double-blind, randomised, multicentre, comparative trial. Lancet. 1984 Sep 22;2(8404):659–662. doi: 10.1016/s0140-6736(84)91224-8. [DOI] [PubMed] [Google Scholar]
- Hansky J., Korman M. G. Long-term cimetidine in duodenal ulcer disease. Dig Dis Sci. 1979 Jun;24(6):465–467. doi: 10.1007/BF01299829. [DOI] [PubMed] [Google Scholar]
- Hentschel E., Schütze K., Weiss W., Rüdiger E., Judmair G., Reichel W., Kerstan E., Horton J. Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study. Gut. 1983 Sep;24(9):853–856. doi: 10.1136/gut.24.9.853. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jorde R., Bostad L., Burhol P. G. Asymptomatic gastric ulcer: a follow-up study in patients with previous gastric ulcer disease. Lancet. 1986 Jan 18;1(8473):119–121. doi: 10.1016/s0140-6736(86)92260-9. [DOI] [PubMed] [Google Scholar]
- Kinloch J. D., Pearson A. J., Woolf I. L., Young P. H. The effect of cimetidine on the maintenance of healing of gastric ulceration. Postgrad Med J. 1984 Oct;60(708):665–667. doi: 10.1136/pgmj.60.708.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madsen P., Schousen P. Long term results of truncal vagotomy and pyloroplasty for gastric ulcer. Br J Surg. 1982 Nov;69(11):651–654. doi: 10.1002/bjs.1800691107. [DOI] [PubMed] [Google Scholar]
- Marks I. N., Wright J. P., Lucke W., Girdwood A. H. Relapse rates after initial ulcer healing with sucralfate and cimetidine. Scand J Gastroenterol. 1982 Apr;17(3):429–432. doi: 10.3109/00365528209182081. [DOI] [PubMed] [Google Scholar]
- Myren J. The natural history of peptic ulcer--views in the 1980s. Scand J Gastroenterol. 1983 Nov;18(8):993–997. doi: 10.3109/00365528309181831. [DOI] [PubMed] [Google Scholar]