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. 1987 Apr;28(4):455–459. doi: 10.1136/gut.28.4.455

Effects of nifedipine on gastric acid secretion and gastrin release in man.

K E McColl, N M Buchanan, G Laferla, J Hearns, K Buchanan, G P Crean
PMCID: PMC1432821  PMID: 3556337

Abstract

As calcium is important in the regulation of gastric acid secretion and gastrin release, we have examined the effect of the calcium antagonist nifedipine on these processes in man. Nifedipine 30 mg orally inhibited basal acid output by 37% (p less than 0.025) and that stimulated by low infusion rates of pentagastrin--that is, 0.031 and 0.062 microgram/kg/h by 44% (p = 0.05) and 39% (p less than 0.02) respectively. On increasing the pentagastrin infusion rate the inhibition was surmounted suggesting it was competitive in type. Nifedipine did not affect basal or Oxo meal stimulated gastrin concentrations in normal volunteers nor did it affect resting serum gastrin or calcium stimulated increase in gastrin in a single patient with Zollinger-Ellison syndrome. These findings are consistent with the transmembrane flux of calcium ions being involved in basal and pentagastrin stimulated acid secretion in man.

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Selected References

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  1. Ahlman H., Nilsson O., Grönstad K. O., Skolnik G., Tisell L. E., Dahlström A. Verapamil and diarrhoea in the carcinoid syndrome--clinical and experimental observations on serotonin release. Br J Cancer. 1986 Aug;54(2):251–256. doi: 10.1038/bjc.1986.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blackwell J. N., Holt S., Heading R. C. Effect of nifedipine on oesophageal motility and gastric emptying. Digestion. 1981;21(1):50–56. doi: 10.1159/000198520. [DOI] [PubMed] [Google Scholar]
  3. Brodie M. J., Ganguli P. C., Fine A., Thomson T. J. Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man. Gut. 1977 Feb;18(2):111–114. doi: 10.1136/gut.18.2.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Christiansen J., Kirkegaard P., Olsen P. S., Petersen B. Interaction of calcium and gastrin on gastric acid secretion in duodenal ulcer patients. Gut. 1984 Feb;25(2):174–177. doi: 10.1136/gut.25.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Christiansen J., Rehfeld J. F., Stadil F. Interaction of calcium and magnesium on gastric acid secretion and serum gastrin concentration in man. Gastroenterology. 1975 May;68(5 Pt 1):1140–1143. [PubMed] [Google Scholar]
  6. DONEGAN W. L., SPIRO H. M. Parathyroids and gastric secretion. Gastroenterology. 1960 May;38:750–759. [PubMed] [Google Scholar]
  7. Fiddian-Green R. G., Pittenger G., Kothary P., Vinik A. I. Role of calcium in the stimulus-secretion coupling of antral gastrin release. Endocrinology. 1983 Feb;112(2):753–760. doi: 10.1210/endo-112-2-753. [DOI] [PubMed] [Google Scholar]
  8. Harty R. F., Maico D. G., Brown C. M., McGuigan J. E. Effects of calcium on cholinergic-stimulated gastrin release in the rat. Mol Cell Endocrinol. 1984 Sep;37(2):133–138. doi: 10.1016/0303-7207(84)90044-3. [DOI] [PubMed] [Google Scholar]
  9. Harty R. F., Maico D. G., McGuigan J. E. Role of calcium in antral gastrin release. Gastroenterology. 1981 Mar;80(3):491–497. [PubMed] [Google Scholar]
  10. Kirkegaard P., Christiansen J., Petersen B., Skov Olsen P. Calcium and stimulus-secretion coupling in gastric fundic mucosa. Effect of inhibition of calcium transport by verapamil on gastric acid secretion in the isolated guinea pig fundic mucosa and in healthy subjects. Scand J Gastroenterol. 1982 Jun;17(4):533–538. doi: 10.3109/00365528209182245. [DOI] [PubMed] [Google Scholar]
  11. Levine R. A., Petokas S., Starr A., Eich R. H. Effect of verapamil on basal and pentagastrin-stimulated gastric acid secretion. Clin Pharmacol Ther. 1983 Sep;34(3):399–402. doi: 10.1038/clpt.1983.186. [DOI] [PubMed] [Google Scholar]
  12. Ohneda A., Kobayashi T., Nihei J. Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas. Tohoku J Exp Med. 1983 Jun;140(2):153–159. doi: 10.1620/tjem.140.153. [DOI] [PubMed] [Google Scholar]
  13. Passaro E., Jr, Basso N., Walsh J. H. Calcium challenge in the Zollinger-Ellison syndrome. Surgery. 1972 Jul;72(1):60–67. [PubMed] [Google Scholar]
  14. Rangachari P. K. Histamine release by gastric stimulants. Nature. 1975 Jan 3;253(5486):53–55. doi: 10.1038/253053a0. [DOI] [PubMed] [Google Scholar]
  15. Reeder D. D., Jackson B. M., Ban J., Clendinnen B. G., Davidson W. D., Thompson J. C. Influence of hypercalcemia on gastric secretion and serum gastrin concentrations in man. Ann Surg. 1970 Oct;172(4):540–546. doi: 10.1097/00000658-197010000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Richter J. E., Dalton C. B., Buice R. G., Castell D. O. Nifedipine: a potent inhibitor of contractions in the body of the human esophagus. Studies in healthy volunteers and patients with the nutcracker esophagus. Gastroenterology. 1985 Sep;89(3):549–554. doi: 10.1016/0016-5085(85)90450-0. [DOI] [PubMed] [Google Scholar]
  17. Sewing K. F., Hannemann H. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9–14. doi: 10.1159/000137824. [DOI] [PubMed] [Google Scholar]
  18. Smallwood R. A. Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man. Gut. 1967 Dec;8(6):592–598. doi: 10.1136/gut.8.6.592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Soll A. H. Extracellular calcium and cholinergic stimulation of isolated canine parietal cells. J Clin Invest. 1981 Jul;68(1):270–278. doi: 10.1172/JCI110243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Szelenyi I. Calcium, histamine, and pentagastrin: speculations about the regulation of gastric acid secretion at cellular level. Agents Actions. 1980 Apr;10(1 Pt 2):187–190. doi: 10.1007/BF02024209. [DOI] [PubMed] [Google Scholar]
  21. Traube M., Lange R. C., McAllister R. G., Jr, McCallum R. W. Effect of nifedipine on gastric emptying in normal subjects. Dig Dis Sci. 1985 Aug;30(8):710–712. doi: 10.1007/BF01320483. [DOI] [PubMed] [Google Scholar]

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