Abstract
Forty patients with biopsy proven chronic active hepatitis were studied, 22 received (+)-cyanidanol-3 in a dose of 3 g daily and 18 placebo. Side effects related to cyanidanol were fever (four patients), haemolysis (one patient) and urticaria (one patient). All side effects subsided on discontinuation of the medication. Cyanidanol had an effect no better than placebo on symptoms, laboratory tests, and histological findings on liver biopsy.
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Selected References
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- Blum A. L., Berthet P., Doelle W., Goebell H., Kortüm K., Pelloni S., Peter P., Poulsen H., Strohmeyer G., Tygstrup N. Treatment of acute viral hepatitis with (+)-cyanidanol-3. Lancet. 1977 Dec 3;2(8049):1153–1155. doi: 10.1016/s0140-6736(77)91540-9. [DOI] [PubMed] [Google Scholar]
- Gajdos A., Gajdos-Tërök M., Horn R. The effect of (+)-catechin on the hepatic level of ATP and the lipid content of liver during experimental steatosis. Biochem Pharmacol. 1972 Feb 15;21(4):594–600. doi: 10.1016/0006-2952(72)90338-3. [DOI] [PubMed] [Google Scholar]
- Schomerus H., Wiedmann K. H., Dölle W., Peerenboom H., Strohmeyer G., Balzer K., Goebell H., Dürr H. K., Bode C., Blum A. L. (+)-Cyanidanol-3 in the treatment of acute viral hepatitis: a randomized controlled trial. Hepatology. 1984 Mar-Apr;4(2):331–335. doi: 10.1002/hep.1840040226. [DOI] [PubMed] [Google Scholar]
- Soloway R. D., Summerskill W. H., Baggenstoss A. H., Geall M. G., Gitnićk G. L., Elveback I. R., Schoenfield L. J. Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology. 1972 Nov;63(5):820–833. [PubMed] [Google Scholar]