Abstract
During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas. Appropriate staining techniques showed acid-fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms. Liver biopsy was found to be a high yield and rapid diagnostic procedure in patients with AIDS. Our results suggest that hepatic mycobacterial infection may be more common in the syndrome than previously recognised and that liver biopsy specimens should be examined routinely for the presence of acid-fast bacilli.
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- Alvarez S., McCabe W. R. Extrapulmonary tuberculosis revisited: a review of experience at Boston City and other hospitals. Medicine (Baltimore) 1984 Jan;63(1):25–55. [PubMed] [Google Scholar]
- Fauci A. S., Macher A. M., Longo D. L., Lane H. C., Rook A. H., Masur H., Gelmann E. P. NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med. 1984 Jan;100(1):92–106. doi: 10.7326/0003-4819-100-1-92. [DOI] [PubMed] [Google Scholar]
- Gardner J. D., Ousley M., Godfrey W., Lindsey N. J., Abdou N. I. Mycobacterium fortuitum infection: evidence of bactericidal defect due to hyperactive antigen-specific suppressor cells. Correction in vitro and in vivo by cholinergic agonist and indomethacin. Am J Med. 1982 Nov;73(5):756–764. doi: 10.1016/0002-9343(82)90420-x. [DOI] [PubMed] [Google Scholar]
- Gottlieb M. S., Groopman J. E., Weinstein W. M., Fahey J. L., Detels R. The acquired immunodeficiency syndrome. Ann Intern Med. 1983 Aug;99(2):208–220. doi: 10.7326/0003-4819-99-2-208. [DOI] [PubMed] [Google Scholar]
- Greene J. B., Sidhu G. S., Lewin S., Levine J. F., Masur H., Simberkoff M. S., Nicholas P., Good R. C., Zolla-Pazner S. B., Pollock A. A. Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers. Ann Intern Med. 1982 Oct;97(4):539–546. doi: 10.7326/0003-4819-97-4-539. [DOI] [PubMed] [Google Scholar]
- KORN R. J., KELLOW W. F., HELLER P., CHOMET B., ZIMMERMAN H. J. Hepatic involvement in extrapulmonary tuberculosis; histologic and functional characteristics. Am J Med. 1959 Jul;27(1):60–71. doi: 10.1016/0002-9343(59)90061-0. [DOI] [PubMed] [Google Scholar]
- Kleinhenz M. E., Ellner J. J., Spagnuolo P. J., Daniel T. M. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility. J Clin Invest. 1981 Jul;68(1):153–162. doi: 10.1172/JCI110231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MENGHINI G. One-second needle biopsy of the liver. Gastroenterology. 1958 Aug;35(2):190–199. [PubMed] [Google Scholar]
- Pitchenik A. E., Fischl M. A., Dickinson G. M., Becker D. M., Fournier A. M., O'Connell M. T., Colton R. M., Spira T. J. Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med. 1983 Mar;98(3):277–284. doi: 10.7326/0003-4819-98-3-277. [DOI] [PubMed] [Google Scholar]
- Vieira J., Frank E., Spira T. J., Landesman S. H. Acquired immune deficiency in Haitians: opportunistic infections in previously healthy Haitian immigrants. N Engl J Med. 1983 Jan 20;308(3):125–129. doi: 10.1056/NEJM198301203080303. [DOI] [PubMed] [Google Scholar]