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. 1985 Oct;26(10):1018–1024. doi: 10.1136/gut.26.10.1018

Basal, sham feed and pentagastrin stimulated gastric acid, pepsin and electrolytes after omeprazole 20 mg and 40 mg daily.

J N Thompson, J A Barr, N Collier, J Spencer, A Bush, L Cope, R J Gribble, J H Baron
PMCID: PMC1432935  PMID: 3932137

Abstract

Gastric secretion was measured in nine patients with duodenal ulcer before, and after treatment for four weeks with omeprazole 20 mg or 40 mg daily. Basal acidity and acid output were affected variably by 20 mg, but inhibited totally by 40 mg daily. Sham feed stimulated acid output was reduced by 20 mg daily and completely inhibited by 40 mg daily. Maximal pentagastrin stimulated acid output was halved by 20 mg omeprazole daily and 84% inhibited by 40 mg daily. The reduction in acidity was always greater than the reduction of volume. Pepsin output after pentagastrin was little altered but with the reduced secretory volume pepsin concentrations were increased by both doses. The major cause of reduced aspirate acid output after omeprazole is decreased secretion of the primary acid component of the parietal cell by the proton pump H+K+ ATPase. Duodenogastric alkaline reflux is, however, markedly increased after omeprazole and is an additional factor in the resultant hypoacidity or even anacidity after this drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Faber R. G., Russell R. C., Royston C. M., Whitfield P., Hobsley M. Duodenal reflux during insulin-stimulated secretion. Gut. 1974 Nov;15(11):880–884. doi: 10.1136/gut.15.11.880. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fellenius E., Berglindh T., Sachs G., Olbe L., Elander B., Sjöstrand S. E., Wallmark B. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981 Mar 12;290(5802):159–161. doi: 10.1038/290159a0. [DOI] [PubMed] [Google Scholar]
  3. Fryklund J., Wallmark B., Larsson H., Helander H. F. Effect of omeprazole on gastric secretion in H+,K+-ATPase and in pepsinogen-rich cell fractions from rabbit gastric mucosa. Biochem Pharmacol. 1984 Jan 15;33(2):273–280. doi: 10.1016/0006-2952(84)90485-4. [DOI] [PubMed] [Google Scholar]
  4. Hirschowitz B. I., Fong J. Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion. Am J Physiol. 1983 Dec;245(6):G739–G744. doi: 10.1152/ajpgi.1983.245.6.G739. [DOI] [PubMed] [Google Scholar]
  5. Hobsley M. Pyloric reflux: a modification of the two-component hypothesis of gastric secretion. Clin Sci Mol Med. 1974 Aug;47(2):131–141. doi: 10.1042/cs0470131. [DOI] [PubMed] [Google Scholar]
  6. Hunt J. N., Smith J. L., Jiang C. L., Kessler L. Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion. Dig Dis Sci. 1983 Oct;28(10):897–902. doi: 10.1007/BF01317040. [DOI] [PubMed] [Google Scholar]
  7. Konturek S. J., Kweicień N., Obtułowicz W., Kopp B., Oleksy J. Action of omeprazole (a benzimidazole derivative) on secretory responses to sham feeding and pentagastrin and upon serum gastrin and pancreatic polypeptide in duodenal ulcer patients. Gut. 1984 Jan;25(1):14–18. doi: 10.1136/gut.25.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lind T., Cederberg C., Ekenved G., Haglund U., Olbe L. Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man. Gut. 1983 Apr;24(4):270–276. doi: 10.1136/gut.24.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Müller P., Dammann H. G., Seitz H., Simon B. Effect of repeated, once daily, oral omeprazole on gastric secretion. Lancet. 1983 Jan 1;1(8314-5):66–66. doi: 10.1016/s0140-6736(83)91596-9. [DOI] [PubMed] [Google Scholar]
  10. Okosdinossian E. T., el-Munshid H. A. Composition of the alkaline component of human gastric juice: effect of swallowed saliva and duodeno-gastric reflux. Scand J Gastroenterol. 1977;12(8):945–950. doi: 10.3109/00365527709181354. [DOI] [PubMed] [Google Scholar]
  11. Olbe L., Haglund U., Leth R., Lind T., Cederberg C., Ekenved G., Elander B., Fellenius E., Lundborg P., Wallmark B. Effects of substituted benzimidazole (H 149/94) on gastric acid secretion in humans. Gastroenterology. 1982 Jul;83(1 Pt 2):193–198. [PubMed] [Google Scholar]
  12. Vatier, Cheret A. M., Bonfils S. Le dosage automatique de l'activité protéolytique du suc gastrique. Biol Gastroenterol (Paris) 1968;1:15–29. [PubMed] [Google Scholar]
  13. Walt R. P., Gomes M. D., Wood E. C., Logan L. H., Pounder R. E. Effect of daily oral omeprazole on 24 hour intragastric acidity. Br Med J (Clin Res Ed) 1983 Jul 2;287(6384):12–14. doi: 10.1136/bmj.287.6384.12. [DOI] [PMC free article] [PubMed] [Google Scholar]

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