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. 1985 Jul;26(7):700–703. doi: 10.1136/gut.26.7.700

Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test.

G Basilisco, A Bozzani, G Camboni, M Recchia, M Quatrini, D Conte, R Penagini, P A Bianchi
PMCID: PMC1433011  PMID: 4018633

Abstract

The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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