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. 1988 Jan;29(1):94–100. doi: 10.1136/gut.29.1.94

Gastric cell c-AMP stimulating autoantibodies in duodenal ulcer disease.

F De Lazzari 1, R Mirakian 1, L Hammond 1, C Venturi 1, R Naccarato 1, G F Bottazzo 1
PMCID: PMC1433275  PMID: 2830177

Abstract

Gastric cell c-AMP stimulating antibodies (GCS-Ab) were studied in 30 patients with duodenal ulcer (DU) disease. Semipurified immunoglobulin (Ig) preparations from 13/30 patients stimulated c-AMP production in parietal cell enriched gastric cell suspensions obtained from male guinea pig stomachs. Maximum stimulation (varying between 260 and 547%) was reached after four hours incubation with 2 and 4 mg/ml Ig concentrations. The 13 patients with gastric cell stimulating antibodies (GCS-Ab), all male patients, developed the disease at a younger age (nine of 13 under the age of 30), had a longer duration of symptoms (mean 18.4 years), and had a higher incidence of DU in their families (61%). Eight of 13 (61%) in the GCS-Ab+ group did not respond to anti-H2-R drugs, whereas in the negative patients only three of 17 (18%) were classified as 'non-responders'. Remarkably few conventional autoantibodies were detected in our series. Gastric cell stimulating antibodies are a new addition to the growing list of receptor antibodies in human diseases and the described in vitro test should provide an easier tool for screening large populations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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