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. 1988 Feb;29(2):153–156. doi: 10.1136/gut.29.2.153

Somatostatin does not reduce oesophageal variceal pressure in liver cirrhotics.

G Kleber 1, T Sauerbruch 1, G Fischer 1, G Paumgartner 1
PMCID: PMC1433282  PMID: 2894336

Abstract

Transmural oesophageal variceal pressure was determined by direct puncture of the varices in 27 patients with liver cirrhosis and oesophageal varices. Variceal pressure was not influenced three to six minutes after somatostatin bolus administration and slightly increased during somatostatin infusion. Thus, potential haemostatic benefits of somatostatin cannot be explained by pressure reductions in the varices.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bosch J., Kravetz D., Rodes J. Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: comparison with vasopressin. Gastroenterology. 1981 Mar;80(3):518–525. [PubMed] [Google Scholar]
  2. Clements D., Rhodes J. M., Elias E. Effect of somatostatin on oesophageal variceal pressure assessed by direct measurement. J Hepatol. 1986;2(2):262–266. doi: 10.1016/s0168-8278(86)80085-x. [DOI] [PubMed] [Google Scholar]
  3. Jenkins S. A., Baxter J. N., Corbett W. A., Shields R. Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man. Br J Surg. 1985 Dec;72(12):1009–1012. doi: 10.1002/bjs.1800721225. [DOI] [PubMed] [Google Scholar]
  4. Jenkins S. A., Baxter J. N., Corbett W., Devitt P., Ware J., Shields R. A prospective randomised controlled clinical trial comparing somatostatin and vasopressin in controlling acute variceal haemorrhage. Br Med J (Clin Res Ed) 1985 Jan 26;290(6464):275–278. doi: 10.1136/bmj.290.6464.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mannes G. A., Thieme C., Stellaard F., Wang T., Sauerbruch T., Paumgartner G. Prognostic significance of serum bile acids in cirrhosis. Hepatology. 1986 Jan-Feb;6(1):50–53. doi: 10.1002/hep.1840060110. [DOI] [PubMed] [Google Scholar]
  6. Pugh R. N., Murray-Lyon I. M., Dawson J. L., Pietroni M. C., Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973 Aug;60(8):646–649. doi: 10.1002/bjs.1800600817. [DOI] [PubMed] [Google Scholar]
  7. Raptis S., Zoupas C. Somatostatin not helpful in bleeding esophageal varices. N Engl J Med. 1979 Mar 29;300(13):736–737. doi: 10.1056/NEJM197903293001317. [DOI] [PubMed] [Google Scholar]
  8. Sonnenberg G. E., Keller U., Perruchoud A., Burckhardt D., Gyr K. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology. 1981 Mar;80(3):526–532. [PubMed] [Google Scholar]
  9. Staritz M., Poralla T., Meyer zum Büschenfelde K. H. Intravascular oesophageal variceal pressure (IOVP) assessed by endoscopic fine needle puncture under basal conditions, Valsalva's manoeuvre and after glyceryltrinitrate application. Gut. 1985 May;26(5):525–530. doi: 10.1136/gut.26.5.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Thulin L., Tydén G., Samnegård H., Muhrbeck O., Efendić S. Treatment of bleeding oesophageal varices with somatostatin. Acta Chir Scand. 1979;145(6):395–398. [PubMed] [Google Scholar]

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