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. 1988 Feb;29(2):167–172. doi: 10.1136/gut.29.2.167

Maturation of the lower oesophageal sphincter in the preterm baby.

S J Newell 1, P K Sarkar 1, G M Durbin 1, I W Booth 1, A S McNeish 1
PMCID: PMC1433285  PMID: 3345927

Abstract

There are few reported studies of the lower oesophageal sphincter in preterm infants and none has investigated babies of less than 34 weeks gestation. Using a modified manometric technique suitable for use on very low birth weight infants we have measured sphincter pressures on 68 occasions in 25 infants of postconceptional age between 27 and 41 weeks. In even the most preterm infants the lower oesophageal sphincter could be defined. The mean effective sphincter pressure rose from 3.8 mmHg in infants of less than 29 weeks gestation to 18.1 mmHg in the term infant. This rise in effective sphincter pressure correlated well with increasing postconceptional age (r = 0.81). This pattern of maturation in our patients was unaffected by intrauterine growth retardation, postnatal illness, or concurrent xanthine administration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bland J. M., Altman D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed] [Google Scholar]
  2. Boix-Ochoa J., Canals J. Maturation of the lower esophagus. J Pediatr Surg. 1976 Oct;11(5):749–756. doi: 10.1016/0022-3468(76)90099-3. [DOI] [PubMed] [Google Scholar]
  3. Dennish G. W., Castell D. O. Caffeine and the lower esophageal sphincter. Am J Dig Dis. 1972 Nov;17(11):993–996. doi: 10.1007/BF02239138. [DOI] [PubMed] [Google Scholar]
  4. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  5. Euler A. R., Ament M. E. Value of esophageal manometric studies in the gastroesophageal reflux of infancy. Pediatrics. 1977 Jan;59(1):58–61. [PubMed] [Google Scholar]
  6. Euler A. R., Byrne W. J. Twenty-four-hour esophageal intraluminal pH probe testing: a comparative analysis. Gastroenterology. 1981 May;80(5 Pt 1):957–961. [PubMed] [Google Scholar]
  7. GRYBOSKI J. D. THE SWALLOWING MECHANISM OF THE NEONATE. I. ESOPHAGEAL AND GASTRIC MOTILITY. Pediatrics. 1965 Mar;35:445–452. [PubMed] [Google Scholar]
  8. Herbst J. J., Minton S. D., Book L. S. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr. 1979 Nov;95(5 Pt 1):763–768. doi: 10.1016/s0022-3476(79)80733-7. [DOI] [PubMed] [Google Scholar]
  9. Kenigsberg K., Aiges H., Alperstein G., Daum F. A unique device to measure lower esophageal sphincter pressure in unsedated infants. J Pediatr Surg. 1981 Jun;16(3):370–373. doi: 10.1016/s0022-3468(81)80697-5. [DOI] [PubMed] [Google Scholar]
  10. Leape L. L., Holder T. M., Franklin J. D., Amoury R. A., Ashcraft K. W. Respiratory arrest in infants secondary to gastroesophageal reflux. Pediatrics. 1977 Dec;60(6):924–928. [PubMed] [Google Scholar]
  11. Mayne A. J., Brown G. A., Sule D., McNeish A. S. Postnatal development of disaccharidase activities in jejunal fluid of preterm neonates. Gut. 1986 Nov;27(11):1357–1361. doi: 10.1136/gut.27.11.1357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Moroz S. P., Espinoza J., Cumming W. A., Diamant N. E. Lower esophageal sphincter function in children with and without gastroesophageal reflux. Gastroenterology. 1976 Aug;71(2):236–241. [PubMed] [Google Scholar]
  13. Pope C. E., 2nd A dynamic test of sphincter strength: its application to the lower esophageal sphincter. Gastroenterology. 1967 May;52(5):779–786. [PubMed] [Google Scholar]
  14. Vandenplas Y., De Wolf D., Sacre L. Influence of xanthines on gastroesophageal reflux in infants at risk for sudden infant death syndrome. Pediatrics. 1986 Jun;77(6):807–810. [PubMed] [Google Scholar]
  15. Winans C. S., Harris L. D. Quantitation of lower esophageal sphincter competence. Gastroenterology. 1967 May;52(5):773–778. [PubMed] [Google Scholar]

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