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. 1986 Jun;27(6):726–727. doi: 10.1136/gut.27.6.726

Cross hepatotoxicity between tricyclic antidepressants.

D Larrey, B Rueff, D Pessayre, G Danan, M Algard, J Geneve, J P Benhamou
PMCID: PMC1433318  PMID: 3721296

Abstract

Cross hepatotoxicity between drugs in very uncommon. We report the case of a patient in whom acute hepatitis was induced by a tricyclic antidepressant, amineptine, and recurred early after administration of another tricyclic antidepressant, clomipramine. This observation suggests that the tricyclic ring is involved in the mechanism of the deleterious effect of both drugs to the liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrieu J., Doll J., Coffinier C. Hépatites dues à l'amineptine. Quatre observations. Gastroenterol Clin Biol. 1982 Nov;6(11):915–918. [PubMed] [Google Scholar]
  2. Guérin C., Casez J. P., Vital-Durand D., Levrat R. Allergie au paracétamol. Un cas d'atteinte hépatique et cutanée. Therapie. 1984 Jan-Feb;39(1):47–49. [PubMed] [Google Scholar]
  3. HERRON G., BOURDO S. Jaundice secondary to promazine, and an analysis of possible cross sensitivities between phenothiazine derivatives. Gastroenterology. 1960 Jan;38:87–90. [PubMed] [Google Scholar]
  4. Joshi P. H., Conn H. O. The syndrome of methoxyflurane-associated hepatitis. Ann Intern Med. 1974 Mar;80(3):395–401. doi: 10.7326/0003-4819-80-3-395. [DOI] [PubMed] [Google Scholar]
  5. Keeffe E. B., Reis T. C., Berland J. E. Hepatotoxicity to both erythromycin estolate and erythromycin ethylsuccinate. Dig Dis Sci. 1982 Aug;27(8):701–704. doi: 10.1007/BF01393764. [DOI] [PubMed] [Google Scholar]
  6. Lewis J. H., Zimmerman H. J., Ishak K. G., Mullick F. G. Enflurane hepatotoxicity. A clinicopathologic study of 24 cases. Ann Intern Med. 1983 Jun;98(6):984–992. doi: 10.7326/0003-4819-98-6-984. [DOI] [PubMed] [Google Scholar]
  7. Tolman K. G., Sannella J. J., Freston J. W. Chemical structure of erythromycin and hepatotoxicity. Ann Intern Med. 1974 Jul;81(1):58–60. doi: 10.7326/0003-4819-81-1-58. [DOI] [PubMed] [Google Scholar]
  8. Zarski J. P., Aubert H., Rachail M. Toxicité hépatique des nouveaux anti-dépresseurs. A propos d'une observation. Gastroenterol Clin Biol. 1983 Feb;7(2):220–221. [PubMed] [Google Scholar]

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