Skip to main content
NCBI home page
Gut logoLink to Gut
. 1986 Aug;27(8):972–985. doi: 10.1136/gut.27.8.972

Human intestinal intraepithelial lymphocytes.

W O Dobbins 3rd
PMCID: PMC1433361  PMID: 3525341

Full text

PDF
972

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnaud-Battandier F., Nelson D. L. Immunologic characteristics of intestinal lymphoid cells of the guinea pig. Gastroenterology. 1982 Feb;82(2):248–253. [PubMed] [Google Scholar]
  2. Austin L. L., Dobbins W. O., 3rd Intraepithelial leukocytes of the intestinal mucosa in normal man and in Whipple's disease: a light- and electron-microscopic study. Dig Dis Sci. 1982 Apr;27(4):311–320. doi: 10.1007/BF01296750. [DOI] [PubMed] [Google Scholar]
  3. Barclay A. N., Mason D. W. Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli. J Exp Med. 1982 Dec 1;156(6):1665–1676. doi: 10.1084/jem.156.6.1665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bartnik W., ReMine S. G., Chiba M., Thayer W. R., Shorter R. G. Isolation and characterization of colonic intraepithelial and lamina proprial lymphocytes. Gastroenterology. 1980 May;78(5 Pt 1):976–985. [PubMed] [Google Scholar]
  5. Bhalla D. K., Owen R. L. Cell renewal and migration in lymphoid follicles of Peyer's patches and cecum--an autoradiographic study in mice. Gastroenterology. 1982 Feb;82(2):232–242. [PubMed] [Google Scholar]
  6. Bottazzo G. F., Pujol-Borrell R., Hanafusa T., Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet. 1983 Nov 12;2(8359):1115–1119. doi: 10.1016/s0140-6736(83)90629-3. [DOI] [PubMed] [Google Scholar]
  7. Cahill R. N., Poskitt D. C., Frost D. C., Trnka Z. Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes. J Exp Med. 1977 Feb 1;145(2):420–428. doi: 10.1084/jem.145.2.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cerf-Bensussan N., Guy-Grand D., Griscelli C. Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity. Gut. 1985 Jan;26(1):81–88. doi: 10.1136/gut.26.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cerf-Bensussan N., Quaroni A., Kurnick J. T., Bhan A. K. Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells. J Immunol. 1984 May;132(5):2244–2252. [PubMed] [Google Scholar]
  10. Cerf-Bensussan N., Schneeberger E. E., Bhan A. K. Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J Immunol. 1983 Jun;130(6):2615–2622. [PubMed] [Google Scholar]
  11. Chiba M., Bartnik W., ReMine S. G., Thayer W. R., Shorter R. G. Human colonic intraepithelial and lamina proprial lymphocytes: cytotoxicity in vitro and the potential effects of the isolation method on their functional properties. Gut. 1981 Mar;22(3):177–186. doi: 10.1136/gut.22.3.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Chin Y. H., Carey G. D., Woodruff J. J. Lymphocyte recognition of lymph node high endothelium. IV. Cell surface structures mediating entry into lymph nodes. J Immunol. 1982 Nov;129(5):1911–1915. [PubMed] [Google Scholar]
  13. Clancy R., Cripps A., Chipchase H. Regulation of human gut B lymphocytes by T lymphocytes. Gut. 1984 Jan;25(1):47–51. doi: 10.1136/gut.25.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Clement L. T., Dagg M. K., Landay A. Characterization of human lymphocyte subpopulations: alloreactive cytotoxic T-lymphocyte precursor and effector cells are phenotypically distinct from Leu 2+ suppressor cells. J Clin Immunol. 1984 Sep;4(5):395–402. doi: 10.1007/BF00917143. [DOI] [PubMed] [Google Scholar]
  15. Corazza G. R., Frazzoni M., Gasbarrini G. Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased? Gut. 1984 Feb;25(2):158–162. doi: 10.1136/gut.25.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Darlington D., Rogers A. W. Epithelial lymphocytes in the small intestine of the mouse. J Anat. 1966 Oct;100(Pt 4):813–830. [PMC free article] [PubMed] [Google Scholar]
  17. Dobbins W. O., 3rd, Weinstein W. M. Electron microscopy of the intestine and rectum in acquired immunodeficiency syndrome. Gastroenterology. 1985 Mar;88(3):738–749. doi: 10.1016/0016-5085(85)90145-3. [DOI] [PubMed] [Google Scholar]
  18. Douglas A. P., Weetman A. P. Lymphocytes and the gut. Digestion. 1975;13(6):344–371. doi: 10.1159/000197732. [DOI] [PubMed] [Google Scholar]
  19. Elson C. O., Machelski E., Weiserbs D. B. T cell-B cell regulation in the intestinal lamina propria in Crohn's disease. Gastroenterology. 1985 Aug;89(2):321–327. doi: 10.1016/0016-5085(85)90332-4. [DOI] [PubMed] [Google Scholar]
  20. Ferguson A. Intraepithelial lymphocytes of the small intestine. Gut. 1977 Nov;18(11):921–937. doi: 10.1136/gut.18.11.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ferguson A., Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut. 1971 Dec;12(12):988–994. doi: 10.1136/gut.12.12.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Ferrarini M., Cadoni A., Franzi A. T., Ghigliotti C., Leprini A., Zicca A., Grossi C. E. Ultrastructure and cytochemistry of human peripheral blood lymphocytes. Similarities between the cells of the third population and TG lymphocytes. Eur J Immunol. 1980 Jul;10(7):562–570. doi: 10.1002/eji.1830100714. [DOI] [PubMed] [Google Scholar]
  23. Fiocchi C., Tubbs R. R., Youngman K. R. Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity. Gastroenterology. 1985 Mar;88(3):625–637. doi: 10.1016/0016-5085(85)90130-1. [DOI] [PubMed] [Google Scholar]
  24. Fox C. C., Dvorak A. M., Peters S. P., Kagey-Sobotka A., Lichtenstein L. M. Isolation and characterization of human intestinal mucosal mast cells. J Immunol. 1985 Jul;135(1):483–491. [PubMed] [Google Scholar]
  25. Gallucci B. B., Sale G. E., McDonald G. B., Epstein R., Shulman H. M., Thomas E. D. The fine structure of human rectal epithelium in acute graft-versus-host disease. Am J Surg Pathol. 1982 Jun;6(4):293–305. doi: 10.1097/00000478-198206000-00002. [DOI] [PubMed] [Google Scholar]
  26. Gibson P. R., Hermanowicz A., Verhaar H. J., Ferguson D. J., Bernal A. L., Jewell D. P. Isolation of intestinal mononuclear cells: factors released which affect lymphocyte viability and function. Gut. 1985 Jan;26(1):60–68. doi: 10.1136/gut.26.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Greenwood J. H., Austin L. L., Dobbins W. O., 3rd In vitro characterization of human intestinal intraepithelial lymphocytes. Gastroenterology. 1983 Nov;85(5):1023–1035. [PubMed] [Google Scholar]
  28. Griscelli C., Vassalli P., McCluskey R. T. The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection. J Exp Med. 1969 Dec 1;130(6):1427–1451. doi: 10.1084/jem.130.6.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Grossi C. E., Cadoni A., Zicca A., Leprini A., Ferrarini M. Large granular lymphocytes in human peripheral blood: ultrastructural and cytochemical characterization of the granules. Blood. 1982 Feb;59(2):277–283. [PubMed] [Google Scholar]
  30. Grossi C. E., Webb S. R., Zicca A., Lydyard P. M., Moretta L., Mingari M. C., Cooper M. D. Morphological and histochemical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG. J Exp Med. 1978 May 1;147(5):1405–1417. doi: 10.1084/jem.147.5.1405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Grossi C. E., Zicca A., Cadoni A., Mingari M. C., Moretta A., Moretta L. Ultrastructural characteristics of human T cell clones with various cytolytic activities. Eur J Immunol. 1983 Aug;13(8):670–677. doi: 10.1002/eji.1830130812. [DOI] [PubMed] [Google Scholar]
  32. Guy-Grand D., Griscelli C., Vassalli P. The gut-associated lymphoid system: nature and properties of the large dividing cells. Eur J Immunol. 1974 Jun;4(6):435–443. doi: 10.1002/eji.1830040610. [DOI] [PubMed] [Google Scholar]
  33. Guy-Grand D., Griscelli C., Vassalli P. The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. J Exp Med. 1978 Dec 1;148(6):1661–1677. doi: 10.1084/jem.148.6.1661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Husband A. J., Gowans J. L. The origin and antigen-dependent distribution of IgA-containing cells in the intestine. J Exp Med. 1978 Nov 1;148(5):1146–1160. doi: 10.1084/jem.148.5.1146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Husband A. J. Kinetics of extravasation and redistribution of IgA-specific antibody-containing cells in the intestine. J Immunol. 1982 Mar;128(3):1355–1359. [PubMed] [Google Scholar]
  36. Janossy G., Tidman N., Selby W. S., Thomas J. A., Granger S., Kung P. C., Goldstein G. Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature. 1980 Nov 6;288(5786):81–84. doi: 10.1038/288081a0. [DOI] [PubMed] [Google Scholar]
  37. Kotler D. P., Gaetz H. P., Lange M., Klein E. B., Holt P. R. Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med. 1984 Oct;101(4):421–428. doi: 10.7326/0003-4819-101-4-421. [DOI] [PubMed] [Google Scholar]
  38. Kraal G., Weissman I. L., Butcher E. C. Differences in in vivo distribution and homing of T cell subsets to mucosal vs nonmucosal lymphoid organs. J Immunol. 1983 Mar;130(3):1097–1102. [PubMed] [Google Scholar]
  39. Lyscom N., Brueton M. J. Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. Immunology. 1982 Apr;45(4):775–783. [PMC free article] [PubMed] [Google Scholar]
  40. Marsh M. N., Mathan M., Mathan V. I. Studies of intestinal lymphoid tissue. VII. The secondary nature of lymphoid cell "activation" in the jejunal lesion of tropical sprue. Am J Pathol. 1983 Sep;112(3):302–312. [PMC free article] [PubMed] [Google Scholar]
  41. Marsh M. N. Studies of intestinal lymphoid tissue. I. Electron microscopic evidence of 'blast transformation' in epithelial lymphocytes of mouse small intestinal mucosa. Gut. 1975 Sep;16(9):665–674. doi: 10.1136/gut.16.9.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Marsh M. N. Studies of intestinal lymphoid tissue. II. Aspects of proliferation and migration of epithelial lymphocytes in the small intestine of mice. Gut. 1975 Sep;16(9):674–682. doi: 10.1136/gut.16.9.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Marsh M. N. Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue. Gastroenterology. 1980 Sep;79(3):481–492. [PubMed] [Google Scholar]
  44. Meader R. D., Landers D. F. Electron and light microscopic observations on relationships between lymphocytes and intestinal epithelium. Am J Anat. 1967 Nov;121(3):763–773. doi: 10.1002/aja.1001210318. [DOI] [PubMed] [Google Scholar]
  45. Meuwissen S. G., Feltkamp-Vroom T. M., De La Rivière A. B., Von Dem Borne A. E., Tytgat G. N. Analysis of the lympho-plasmacytic infiltrate in Crohn's disease with special reference to identification of lymphocyte-subpopulations. Gut. 1976 Oct;17(10):770–780. doi: 10.1136/gut.17.10.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Mowat A. M., Ferguson A. Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine. Gastroenterology. 1982 Aug;83(2):417–423. [PubMed] [Google Scholar]
  47. Mowat A. M., Tait R. C., MacKenzie S., Davies M. D., Parrott D. M. Analysis of natural killer effector and suppressor activity by intraepithelial lymphocytes from mouse small intestine. Clin Exp Immunol. 1983 Apr;52(1):191–198. [PMC free article] [PubMed] [Google Scholar]
  48. Nauss K. M., Pavlina T. M., Kumar V., Newberne P. M. Functional characteristics of lymphocytes isolated from the rat large intestine. Response to T-cell mitogens and natural killer cell activity. Gastroenterology. 1984 Mar;86(3):468–475. [PubMed] [Google Scholar]
  49. Ogra S. S., Weintraub D., Ogra P. L. Immunologic aspects of human colostrum and milk. III. Fate and absorption of cellular and soluble components in the gastrointestinal tract of the newborn. J Immunol. 1977 Jul;119(1):245–248. [PubMed] [Google Scholar]
  50. Otto H. F. The interepithelial lymphocytes of the intestinum. Morphological observations and immunologic aspects of intestinal enteropathy. Curr Top Pathol. 1973;57:81–121. doi: 10.1007/978-3-642-65465-7_3. [DOI] [PubMed] [Google Scholar]
  51. Owen R. L., Nemanic P. C., Stevens D. P. Ultrastructural observations on giardiasis in a murine model. I. Intestinal distribution, attachment, and relationship to the immune system of Giardia muris. Gastroenterology. 1979 Apr;76(4):757–769. [PubMed] [Google Scholar]
  52. Parker J. W., Wakasa H., Lukes R. J. The morphologic and cytochemical demonstration of lysosomes in lymphocytes incubated with phytohemagglutinin by electron microscopy. Lab Invest. 1965 Oct;14(10):1736–1743. [PubMed] [Google Scholar]
  53. Parrott D. M., Rose M. L. Migration pathways of T lymphocytes in the small intestine. Adv Exp Med Biol. 1978;107:67–74. doi: 10.1007/978-1-4684-3369-2_9. [DOI] [PubMed] [Google Scholar]
  54. Phillips A. D. Epithelial lymphocytes in celiac sprue. Gastroenterology. 1981 May;80(5 Pt 1):1085–1087. [PubMed] [Google Scholar]
  55. Röpke C., Everett N. B. Proliferative kinetics of large and small intraepithelial lymphocytes in the small intestine of the mouse. Am J Anat. 1976 Mar;145(3):395–408. doi: 10.1002/aja.1001450307. [DOI] [PubMed] [Google Scholar]
  56. Schrader J. W., Scollay R., Battye F. Intramucosal lymphocytes of the gut: Lyt-2 and thy-1 phenotype of the granulated cells and evidence for the presence of both T cells and mast cell precursors. J Immunol. 1983 Feb;130(2):558–564. [PubMed] [Google Scholar]
  57. Seelig L. L., Jr, Billingham R. E. Capacity of "transplanted" lymphocytes to traverse the intestinal epithelium of adult rats. Transplantation. 1981 Oct;32(4):308–314. doi: 10.1097/00007890-198110000-00010. [DOI] [PubMed] [Google Scholar]
  58. Selby W. S., Janossy G., Bofill M., Jewell D. P. Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. Gut. 1984 Jan;25(1):32–40. doi: 10.1136/gut.25.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Selby W. S., Janossy G., Bofill M., Jewell D. P. Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol. 1983 Apr;52(1):219–228. [PMC free article] [PubMed] [Google Scholar]
  60. Selby W. S., Janossy G., Goldstein G., Jewell D. P. T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens. Clin Exp Immunol. 1981 Jun;44(3):453–458. [PMC free article] [PubMed] [Google Scholar]
  61. Selby W. S., Janossy G., Jewell D. P. Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract. Gut. 1981 Mar;22(3):169–176. doi: 10.1136/gut.22.3.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Sredni B., Friedman M. M., Bland C. E., Metcalfe D. D. Ultrastructural, biochemical, and functional characteristics of histamine-containing cells cloned from mouse bone marrow: tentative identification as mucosal mast cells. J Immunol. 1983 Aug;131(2):915–922. [PubMed] [Google Scholar]
  63. Tagliabue A., Befus A. D., Clark D. A., Bienenstock J. Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria. J Exp Med. 1982 Jun 1;155(6):1785–1796. doi: 10.1084/jem.155.6.1785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Tseng J. Transfer of lymphocytes of Peyer's patches between immunoglobulin allotype congenic mice: repopulation of the IgA plasma cells in the gut lamina propria. J Immunol. 1981 Nov;127(5):2039–2043. [PubMed] [Google Scholar]
  65. Velardi A., Grossi C. E., Cooper M. D. A large subpopulation of lymphocytes with T helper phenotype (Leu-3/T4+) exhibits the property of binding to NK cell targets and granular lymphocyte morphology. J Immunol. 1985 Jan;134(1):58–64. [PubMed] [Google Scholar]
  66. Zicca A., Leprini A., Cadoni A., Franzi A. T., Ferrarini M., Grossi C. E. Ultrastructural localization of alpha-naphthyl acid esterase in human TM lymphocytes. Am J Pathol. 1981 Oct;105(1):40–46. [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES