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. 1986 Apr;27(4):418–422. doi: 10.1136/gut.27.4.418

Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer.

W K Man, J N Thompson, J H Baron, J Spencer
PMCID: PMC1433383  PMID: 2420686

Abstract

Gastric mucosal concentrations of histamine and of its metabolic enzyme, histamine methyltransferase activity, were measured in patients with duodenal ulcer disease and patients with an apparently normal stomach and duodenum. Patients with duodenal ulcer had significantly less (p less than 0.05) mucosal histamine (median 204 nmol/g) than control subjects (median 252 nmol/g). There was no significant difference between the two groups in their histamine methyltransferase activity values. Omeprazole therapy did not significantly change mucosal histamine (+23%), histamine methyltransferase activity (+5%), histamine release before (+5%) or during (+7%) pentagastrin infusion. It significantly decreased acid secretion during pentagastrin stimulation (median -73%, p less than 0.001). Omeprazole, like cimetidine, does not stop histamine release during pentagastrin stimulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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