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. 1987 Oct;28(10):1267–1274. doi: 10.1136/gut.28.10.1267

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.

M E Baca 1, A M Mowat 1, S MacKenzie 1, D M Parrott 1
PMCID: PMC1433440  PMID: 3500097

Abstract

In this study we have investigated whether addition of bone marrow accessory cells or concurrent administration of recombinant IL-2 would allow intraepithelial lymphocytes (IEL) to induce a systemic, lethal GvHR in irradiated hosts. In addition we have studied the ability of IEL to migrate into lymphoid tissues after intravenous injection and compared this with their locomotor capacity in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bookman M. A., Groves E. S., Matis L. A. Expression of MEL-14 antigen is not an absolute requirement for dissemination to lymph nodes after adoptive transfer of murine T lymphocyte clones. J Immunol. 1986 Oct 1;137(7):2107–2114. [PubMed] [Google Scholar]
  2. Cerf-Bensussan N., Schneeberger E. E., Bhan A. K. Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. J Immunol. 1983 Jun;130(6):2615–2622. [PubMed] [Google Scholar]
  3. Dailey M. O., Fathman C. G., Butcher E. C., Pillemer E., Weissman I. Abnormal migration of T lymphocyte clones. J Immunol. 1982 May;128(5):2134–2136. [PubMed] [Google Scholar]
  4. Davies M. D., Parrott D. M. Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes. Immunology. 1981 Oct;44(2):367–371. [PMC free article] [PubMed] [Google Scholar]
  5. Davies M. D., Parrott D. M. Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. Gut. 1981 Jun;22(6):481–488. doi: 10.1136/gut.22.6.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dillon S. B., MacDonald T. T. Functional properties of lymphocytes isolated from murine small intestinal epithelium. Immunology. 1984 Jul;52(3):501–509. [PMC free article] [PubMed] [Google Scholar]
  7. Elsdale T., Bard J. Collagen substrata for studies on cell behavior. J Cell Biol. 1972 Sep;54(3):626–637. doi: 10.1083/jcb.54.3.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ferguson A. Intraepithelial lymphocytes of the small intestine. Gut. 1977 Nov;18(11):921–937. doi: 10.1136/gut.18.11.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Guy-Grand D., Griscelli C., Vassalli P. The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. J Exp Med. 1978 Dec 1;148(6):1661–1677. doi: 10.1084/jem.148.6.1661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Issekutz T. B., Webster D. M., Stoltz J. M. Lymphocyte recruitment in vaccinia virus-induced cutaneous delayed-type hypersensitivity. Immunology. 1986 May;58(1):87–94. [PMC free article] [PubMed] [Google Scholar]
  11. Jalkanen S., Reichert R. A., Gallatin W. M., Bargatze R. F., Weissman I. L., Butcher E. C. Homing receptors and the control of lymphocyte migration. Immunol Rev. 1986 Jun;91:39–60. doi: 10.1111/j.1600-065x.1986.tb01483.x. [DOI] [PubMed] [Google Scholar]
  12. Klein J. R., Kagnoff M. F. Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice. J Exp Med. 1984 Dec 1;160(6):1931–1936. doi: 10.1084/jem.160.6.1931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Korngold R., Sprent J. Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences. J Immunol. 1985 Nov;135(5):3004–3010. [PubMed] [Google Scholar]
  14. Lyscom N., Brueton M. J. Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. Immunology. 1982 Apr;45(4):775–783. [PMC free article] [PubMed] [Google Scholar]
  15. MacDonald T. T., Ferguson A. Small intestinal epithelial cell kinetics and protozoal infection in mice. Gastroenterology. 1978 Mar;74(3):496–500. [PubMed] [Google Scholar]
  16. Mowat A. M., MacKenzie S., Baca M. E., Felstein M. V., Parrott D. M. Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli. Immunology. 1986 Aug;58(4):627–634. [PMC free article] [PubMed] [Google Scholar]
  17. Mowat A. M., Tait R. C., MacKenzie S., Davies M. D., Parrott D. M. Analysis of natural killer effector and suppressor activity by intraepithelial lymphocytes from mouse small intestine. Clin Exp Immunol. 1983 Apr;52(1):191–198. [PMC free article] [PubMed] [Google Scholar]
  18. Parrott D. M., Tait C., MacKenzie S., Mowat A. M., Davies M. D., Micklem H. S. Analysis of the effector functions of different populations of mucosal lymphocytes. Ann N Y Acad Sci. 1983 Jun 30;409:307–320. doi: 10.1111/j.1749-6632.1983.tb26879.x. [DOI] [PubMed] [Google Scholar]
  19. Phillips A. D., Rice S. J., France N. E., Walker-Smith J. A. Small intestinal intraepithelial lymphocyte levels in cow's milk protein intolerance. Gut. 1979 Jun;20(6):509–512. doi: 10.1136/gut.20.6.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Selby W. S., Janossy G., Jewell D. P. Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract. Gut. 1981 Mar;22(3):169–176. doi: 10.1136/gut.22.3.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shields J. G., Parrott D. M. Appearance of delayed-type hypersensitivity effector cells in murine gut mucosa. Immunology. 1985 Apr;54(4):771–776. [PMC free article] [PubMed] [Google Scholar]
  22. Shields J. M., Haston W., Wilkinson P. C. Invasion of collagen gels by mouse lymphoid cells. Immunology. 1984 Feb;51(2):259–268. [PMC free article] [PubMed] [Google Scholar]
  23. Tagliabue A., Luini W., Soldateschi D., Boraschi D. Natural killer activity of gut mucosal lymphoid cells in mice. Eur J Immunol. 1981 Nov;11(11):919–922. doi: 10.1002/eji.1830111112. [DOI] [PubMed] [Google Scholar]

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