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. 1988 Apr;29(4):522–533. doi: 10.1136/gut.29.4.522

Deoxycholic acid and the pathogenesis of gall stones.

S N Marcus 1, K W Heaton 1
PMCID: PMC1433553  PMID: 3286385

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Selected References

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  1. Admirand W. H., Small D. M. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest. 1968 May;47(5):1043–1052. doi: 10.1172/JCI105794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ahlberg J., Angelin B., Einarsson K., Hellstrom K., Leijd B. Influence of deoxycholic acid on biliary lipids in man. Clin Sci Mol Med. 1977 Sep;53(3):249–256. doi: 10.1042/cs0530249. [DOI] [PubMed] [Google Scholar]
  3. Ahlberg J., Angelin B., Einarsson K., Hellström K., Leijd B. Biliary lipid composition in normo- and hyperlipoproteinemia. Gastroenterology. 1980 Jul;79(1):90–94. [PubMed] [Google Scholar]
  4. Ahlberg J., Curstedt T., Einarsson K., Sjövall J. Molecular species of biliary phosphatidylcholines in gallstone patients: the influence of treatment with cholic acid and chenodeoxycholic acid. J Lipid Res. 1981 Mar;22(3):404–409. [PubMed] [Google Scholar]
  5. Ahlberg J., Curstedt T., Einarsson K., Sjövall J. Molecular species of biliary phosphatidylcholines in gallstone patients: the influence of treatment with cholic acid and chenodeoxycholic acid. J Lipid Res. 1981 Mar;22(3):404–409. [PubMed] [Google Scholar]
  6. Almond H. R., Vlahcevic Z. R., Bell C. C., Jr, Gregory D. H., Swell L. Bile acid pools, kinetics and biliary lipid composition before and after cholecystectomy. N Engl J Med. 1973 Dec 6;289(23):1213–1216. doi: 10.1056/NEJM197312062892302. [DOI] [PubMed] [Google Scholar]
  7. Alvaro D., Angelico F., Attili A. F., Antonini R., Mazzarella B., Ginanni Corradini S., Gentile S., Bracci F., Angelico M. Plasma lipid lipoproteins and biliary lipid composition in female gallstone patients. Biomed Biochim Acta. 1986;45(6):761–768. [PubMed] [Google Scholar]
  8. Angelin B., Einarsson K., Ewerth S., Leijd B. Biliary lipid composition in patients with porta cirrhosis of the liver. Scand J Gastroenterol. 1980;15(7):849–852. doi: 10.3109/00365528009181540. [DOI] [PubMed] [Google Scholar]
  9. Angelin B., Einarsson K., Leijd B. Bile acid metabolism in hypothyroid subjects: response to substitution therapy. Eur J Clin Invest. 1983 Feb;13(1):99–106. doi: 10.1111/j.1365-2362.1983.tb00071.x. [DOI] [PubMed] [Google Scholar]
  10. Aries V., Hill M. J. Degradation of steroids by intestinal bacteria. II. Enzymes catalysing the oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl group. Biochim Biophys Acta. 1970 May 5;202(3):535–543. doi: 10.1016/0005-2760(70)90124-4. [DOI] [PubMed] [Google Scholar]
  11. Bennion L. J., Grundy S. M. Risk factors for the development of cholelithiasis in man (first of two parts). N Engl J Med. 1978 Nov 23;299(21):1161–1167. doi: 10.1056/NEJM197811232992104. [DOI] [PubMed] [Google Scholar]
  12. Bouchier I. A. Biochemistry of gallstone formation. Clin Gastroenterol. 1983 Jan;12(1):25–48. [PubMed] [Google Scholar]
  13. Bouchier I. A. Debits and credits: a current account of cholesterol gall stone disease. Gut. 1984 Oct;25(10):1021–1028. doi: 10.1136/gut.25.10.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Burnstein M. J., Ilson R. G., Petrunka C. N., Taylor R. D., Strasberg S. M. Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol gallstones. Gastroenterology. 1983 Oct;85(4):801–807. [PubMed] [Google Scholar]
  15. Cantafora A., Angelico M., Di Biase A., Pièche U., Bracci F., Attili A. F., Capocaccia L. Structure of biliary phosphatidylcholine in cholesterol gallstone patients. Lipids. 1981 Aug;16(8):589–592. doi: 10.1007/BF02534904. [DOI] [PubMed] [Google Scholar]
  16. Carey M. C., Small D. M. The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest. 1978 Apr;61(4):998–1026. doi: 10.1172/JCI109025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Carulli N., Loria P., Bertolotti M., Ponz de Leon M., Menozzi D., Medici G., Piccagli I. Effects of acute changes of bile acid pool composition on biliary lipid secretion. J Clin Invest. 1984 Aug;74(2):614–624. doi: 10.1172/JCI111459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Carulli N., Ponz De Leon M., Zironi F., Pinetti A., Smerieri A., Iori R., Loria P. Hepatic cholesterol and bile acid metabolism in subjects with gallstones: comparative effects of short erm feeding of chenodeoxycholic and ursodeoxycholic acid. J Lipid Res. 1980 Jan;21(1):35–43. [PubMed] [Google Scholar]
  19. Carulli N., Ponz de Leon M., Loria P., Iori R., Rosi A., Romani M. Effect of the selective expansion of cholic acid pool on bile lipid composition: possible mechanism of bile acid induced biliary cholesterol desaturation. Gastroenterology. 1981 Sep;81(3):539–546. [PubMed] [Google Scholar]
  20. Carulli N., Ponz de Leon M., Zironi F., Iori R., Loria P. Bile acid feeding and hepatic sterol metabolism: effect of deoxycholic acid. Gastroenterology. 1980 Oct;79(4):637–641. [PubMed] [Google Scholar]
  21. Di Donato P., Carubbi F., Ponz de Leon M., Carulli N. Effect of small doses of deoxycholic acid on bile cholesterol saturation in patients with liver cirrhosis. Gut. 1986 Jan;27(1):23–28. doi: 10.1136/gut.27.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Einarsson K., Nilsell K., Leijd B., Angelin B. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med. 1985 Aug 1;313(5):277–282. doi: 10.1056/NEJM198508013130501. [DOI] [PubMed] [Google Scholar]
  23. FRY R. J., STAFFELDT E. EFFECT OF A DIET CONTAINING SODIUM DEOXYCHOLATE ON THE INTESTINAL MUCOSA OF THE MOUSE. Nature. 1964 Sep 26;203:1396–1398. doi: 10.1038/2031396a0. [DOI] [PubMed] [Google Scholar]
  24. Fisher M. M., Yousef I. M. Sex differences in the bile acid composition of human bile: studies in patients with and without gallstones. Can Med Assoc J. 1973 Aug 4;109(3):190–193. [PMC free article] [PubMed] [Google Scholar]
  25. Gallinger S., Taylor R. D., Harvey P. R., Petrunka C. N., Strasberg S. M. Effect of mucous glycoprotein on nucleation time of human bile. Gastroenterology. 1985 Sep;89(3):648–658. doi: 10.1016/0016-5085(85)90464-0. [DOI] [PubMed] [Google Scholar]
  26. Gollish S. H., Burnstein M. J., Ilson R. G., Petrunka C. N., Strasberg S. M. Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones. Gut. 1983 Sep;24(9):836–844. doi: 10.1136/gut.24.9.836. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gracey M., Papadimitriou J., Burke V., Thomas J., Bower G. Effects on small-intestinal function and structure induced by feeding a deconjugated bile salt. Gut. 1973 Jul;14(7):519–528. doi: 10.1136/gut.14.7.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Grundy S. M. Mechanism of cholesterol gallstones formation. Semin Liver Dis. 1983 May;3(2):97–111. doi: 10.1055/s-2008-1040676. [DOI] [PubMed] [Google Scholar]
  29. Hepner G. W. Altered bile acid metabolism in vegetarians. Am J Dig Dis. 1975 Oct;20(10):935–946. doi: 10.1007/BF01070879. [DOI] [PubMed] [Google Scholar]
  30. Hepner G. W., Hofmann A. F., Malagelada J. R., Szczepanik P. A., Klein P. D. Increased bacterial degradation of bile acids in cholecystectomized patients. Gastroenterology. 1974 Apr;66(4):556–564. [PubMed] [Google Scholar]
  31. Hepner G. W., Hofmann A. F., Thomas P. J. Metabolism of steroid and amino acid moieties of conjugated bile acids in man. I. Cholylglycine. J Clin Invest. 1972 Jul;51(7):1889–1897. doi: 10.1172/JCI106991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Hepner G. W., Hofmann A. F., Thomas P. J. Metabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids. J Clin Invest. 1972 Jul;51(7):1898–1905. doi: 10.1172/JCI106992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Hepner G. W., Sturman J. A., Hofmann A. F., Thomas P. J. Metabolism of steroid and amino acid moieties of conjugated bile acids in man. 3. Cholyltaurine (taurocholic acid). J Clin Invest. 1973 Feb;52(2):433–440. doi: 10.1172/JCI107200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Heuman R., Norrby S., Sjödahl R., Tiselius H. G., Tagesson C. Altered gallbladder bile composition in gallstone disease. Relation to gallbladder wall permeability. Scand J Gastroenterol. 1980;15(5):581–586. doi: 10.3109/00365528009182219. [DOI] [PubMed] [Google Scholar]
  35. Hillman L. C., Peters S. G., Fisher C. A., Pomare E. W. Effects of the fibre components pectin, cellulose, and lignin on bile salt metabolism and biliary lipid composition in man. Gut. 1986 Jan;27(1):29–36. doi: 10.1136/gut.27.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Hofmann A. F., Grundy S. M., Lachin J. M., Lan S. P., Baum R. A., Hanson R. F., Hersh T., Hightower N. C., Jr, Marks J. W., Mekhjian H. Pretreatment biliary lipid composition in white patients with radiolucent gallstones in the National Cooperative Gallstone Study. Gastroenterology. 1982 Oct;83(4):738–752. [PubMed] [Google Scholar]
  37. Holan K. R., Holzbach R. T., Hermann R. E., Cooperman A. M., Claffey W. J. Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology. 1979 Oct;77(4 Pt 1):611–617. [PubMed] [Google Scholar]
  38. Huijbregts A. W., Van Berge-Henegouwen G. P., Hectors M. P., Van Schaik A., Van der Werf S. D. Effects of a standardized wheat bran preparation on biliary lipid composition and bile acid metabolism in young healthy males. Eur J Clin Invest. 1980 Dec;10(6):451–458. doi: 10.1111/j.1365-2362.1980.tb02084.x. [DOI] [PubMed] [Google Scholar]
  39. Hylemon P. B., Cacciapuoti A. F., White B. A., Whitehead T. R., Fricke R. J. 7 alpha-Dehydroxylation of cholic acid by cell extracts of Eubacterium species V.P.I. 12708. Am J Clin Nutr. 1980 Nov;33(11 Suppl):2507–2510. doi: 10.1093/ajcn/33.11.2507. [DOI] [PubMed] [Google Scholar]
  40. Jazrawi R. P., Northfield T. C. Effects of a pharmacological dose of cholecystokinin on bile acid kinetics and biliary cholesterol saturation in man. Gut. 1986 Apr;27(4):355–362. doi: 10.1136/gut.27.4.355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Kajiyama G., Fujiyama M., Yamada K., Horiuchi I., Miyoshi A. THe influence of aging upon gallstones--changes in serum lipids, lithogenesis of bile and cross-sectional views of stones with age. Hiroshima J Med Sci. 1981 Sep;30(3):165–174. [PubMed] [Google Scholar]
  42. LaRusso N. F., Szczepanik P. A., Hofmann A. F. Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. Gastroenterology. 1977 Jan;72(1):132–140. [PubMed] [Google Scholar]
  43. Lee S. P., LaMont J. T., Carey M. C. Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones. J Clin Invest. 1981 Jun;67(6):1712–1723. doi: 10.1172/JCI110209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Leiss O., von Bergmann K., Streicher U., Strotkoetter H. Effect of three different dihydroxy bile acids on intestinal cholesterol absorption in normal volunteers. Gastroenterology. 1984 Jul;87(1):144–149. [PubMed] [Google Scholar]
  45. Low-Beer T. S., Nutter S. Colonic bacterial activity, biliary cholesterol saturation, and pathogenesis of gallstones. Lancet. 1978 Nov 18;2(8099):1063–1065. doi: 10.1016/s0140-6736(78)91800-7. [DOI] [PubMed] [Google Scholar]
  46. Low-Beer T. S., Pomare E. W. Can colonic bacterial metabolites predispose to cholesterol gall stones? Br Med J. 1975 Feb 22;1(5955):438–440. doi: 10.1136/bmj.1.5955.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Low-Beer T. S., Pomare E. W. Regulation of bile salt pool size in man. Br Med J. 1973 May 12;2(5862):338–340. doi: 10.1136/bmj.2.5862.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Marcus S. N., Heaton K. W. Effects of a new, concentrated wheat fibre preparation on intestinal transit, deoxycholic acid metabolism and the composition of bile. Gut. 1986 Aug;27(8):893–900. doi: 10.1136/gut.27.8.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Marcus S. N., Heaton K. W. Intestinal transit, deoxycholic acid and the cholesterol saturation of bile--three inter-related factors. Gut. 1986 May;27(5):550–558. doi: 10.1136/gut.27.5.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. McDougall R. M., Walker K., Thurston O. G. Bile acid alterations in patients with cholesterol gallstones. J Surg Res. 1976 Oct;21(4):233–237. doi: 10.1016/0022-4804(76)90032-9. [DOI] [PubMed] [Google Scholar]
  51. McDougall R. M., Yakymyshyn L., Walker K., Thurston O. G. Effect of wheat bran on serum lipoproteins and biliary lipids. Can J Surg. 1978 Sep;21(5):433–435. [PubMed] [Google Scholar]
  52. Morris J. S., Heaton K. W. The fate of labelled bile salts introduced into the colon. Scand J Gastroenterol. 1974;9(1):33–39. [PubMed] [Google Scholar]
  53. Morris J. S., Low-Beer T. S., Heaton K. W. Bile salt metabolism and the colon. Scand J Gastroenterol. 1973;8(5):425–431. [PubMed] [Google Scholar]
  54. Moskovitz M., White C., Barnett R. N., Stevens S., Russell E., Vargo D., Floch M. H. Diet, fecal bile acids, and neutral sterols in carcinoma of the colon. Dig Dis Sci. 1979 Oct;24(10):746–751. doi: 10.1007/BF01317206. [DOI] [PubMed] [Google Scholar]
  55. Nakayama F., Van der Linden W. Bile from gallbladder harbouring gallstone: can it indicate stone formation? Acta Chir Scand. 1970;136(7):605–610. [PubMed] [Google Scholar]
  56. Nilsell K., Angelin B., Liljeqvist L., Einarsson K. Biliary lipid output and bile acid kinetics in cholesterol gallstone disease. Evidence for an increased hepatic secretion of cholesterol in Swedish patients. Gastroenterology. 1985 Aug;89(2):287–293. doi: 10.1016/0016-5085(85)90328-2. [DOI] [PubMed] [Google Scholar]
  57. Northfield T. C., Hofmann A. F. Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects. Gut. 1975 Jan;16(1):1–11. doi: 10.1136/gut.16.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Northfield T. C., Hofmann A. F. Biliary lipid secretion in gallstone patients. Lancet. 1973 Apr 7;1(7806):747–748. doi: 10.1016/s0140-6736(73)92130-2. [DOI] [PubMed] [Google Scholar]
  59. Northfield T. C., LaRusso N. F., Hofmann A. F., Thistle J. L. Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects. Gut. 1975 Jan;16(1):12–17. doi: 10.1136/gut.16.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Northfield T. C., McColl I. Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine. Gut. 1973 Jul;14(7):513–518. doi: 10.1136/gut.14.7.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Percy-Robb I. W., Jalan K. N., McManus J. P., Sircus W. Effect of ileal resection on bile salt metabolism in patients with ileostomy following proctocolectomy. Clin Sci. 1971 Nov;41(5):371–382. doi: 10.1042/cs0410371. [DOI] [PubMed] [Google Scholar]
  62. Pixley F., Wilson D., McPherson K., Mann J. Effect of vegetarianism on development of gall stones in women. Br Med J (Clin Res Ed) 1985 Jul 6;291(6487):11–12. doi: 10.1136/bmj.291.6487.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Pomare E. W., Heaton K. W. Alteration of bile salt metabolism by dietary fibre (bran). Br Med J. 1973 Nov 3;4(5887):262–264. doi: 10.1136/bmj.4.5887.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Pomare E. W., Heaton K. W. Bile salt metabolism in patients with gallstones in functioning gallbladders. Gut. 1973 Nov;14(11):885–890. doi: 10.1136/gut.14.11.885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Pomare E. W., Heaton K. W., Low-Beer T. S., Espiner H. J. The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients. Am J Dig Dis. 1976 Jul;21(7):521–526. doi: 10.1007/BF01464757. [DOI] [PubMed] [Google Scholar]
  66. Pomare E. W., Heaton K. W. The effect of cholecystectomy on bile salt metabolism. Gut. 1973 Oct;14(10):753–762. [PMC free article] [PubMed] [Google Scholar]
  67. Pomare E. W., Low-Beer T. S. The selective inhibition of chenodeoxycholate synthesis by cholate metabolites in man. Clin Sci Mol Med. 1975 Apr;48(4):315–321. doi: 10.1042/cs0480315. [DOI] [PubMed] [Google Scholar]
  68. Roda E., Aldini R., Mazzella G., Roda A., Sama C., Festi D., Barbara L. Enterohepatic circulation of bile acids after cholecystectomy. Gut. 1978 Jul;19(7):640–649. doi: 10.1136/gut.19.7.640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Rutgeerts P., Ghoos Y., Vantrappen G., Fevery J. Biliary lipid composition in patients with nonoperated Crohn's disease. Dig Dis Sci. 1986 Jan;31(1):27–32. doi: 10.1007/BF01347906. [DOI] [PubMed] [Google Scholar]
  70. Salvioli G., Salati R., Bondi M., Fratalocchi A., Sala B. M., Gibertini A. Bile acid transformation by the intestinal flora and cholesterol saturation in bile. Effects of Streptococcus faecium administration. Digestion. 1982;23(2):80–88. doi: 10.1159/000198691. [DOI] [PubMed] [Google Scholar]
  71. Samuel P., Saypoi G. M., Meilman E., Mosbach E. H., Chafizadeh M. Absorption of bile acids from the large bowel in man. J Clin Invest. 1968 Sep;47(9):2070–2078. doi: 10.1172/JCI105892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Small D. M. The formation of gallstones. Adv Intern Med. 1970;16:243–264. [PubMed] [Google Scholar]
  73. Stellwag E. J., Hylemon P. B. 7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum. J Lipid Res. 1979 Mar;20(3):325–333. [PubMed] [Google Scholar]
  74. Tarpila S., Miettinen T. A., Metsäranta L. Effects of bran on serum cholesterol, faecal mass, fat, bile acids and neutral sterols, and biliary lipids in patients with diverticular disease of the colon. Gut. 1978 Feb;19(2):137–145. doi: 10.1136/gut.19.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Thistle J. L., Hofmann A. F., Yu P. Y., Ott B. Effect of varying doses of chenodeoxycholic acid on bile lipid and biliary bile acid composition in gallstone patients: a dose-response study. Am J Dig Dis. 1977 Jan;22(1):1–6. doi: 10.1007/BF01077389. [DOI] [PubMed] [Google Scholar]
  76. Thistle J. L., Schoenfield L. J. Lithogenic bile among young Indian women. N Engl J Med. 1971 Jan 28;284(4):177–181. doi: 10.1056/NEJM197101282840404. [DOI] [PubMed] [Google Scholar]
  77. Thornton J. R., Heaton K. W. Do colonic bacteria contribute to cholesterol gall-stone formation? Effects of lactulose on bile. Br Med J (Clin Res Ed) 1981 Mar 28;282(6269):1018–1020. doi: 10.1136/bmj.282.6269.1018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Valdivieso V., Palma R., Wünkhaus R., Antezana C., Severín C., Contreras A. Effect of aging on biliary lipid composition and bile acid metabolism in normal Chilean women. Gastroenterology. 1978 May;74(5 Pt 1):871–874. [PubMed] [Google Scholar]
  79. Van der Linden W. Bile acid pattern of patients with and without gallstones. Gastroenterology. 1971 Jun;60(6):1144–1145. [PubMed] [Google Scholar]
  80. Vlahcevic Z. R., Bell C. C., Jr, Buhac I., Farrar J. T., Swell L. Diminished bile acid pool size in patients with gallstones. Gastroenterology. 1970 Aug;59(2):165–173. [PubMed] [Google Scholar]
  81. Vlahcevic Z. R., Bell C. C., Jr, Gregory D. H., Buker G., Juttijudata P., Swell L. Relationship of bile acid pool size to the formation of lithogenic bile in female Indians of the southwest. Gastroenterology. 1972 Jan;62(1):73–83. [PubMed] [Google Scholar]
  82. Vlahcevic Z. R., Prugh M. F., Gregory D. H., Swell L. Disturbances of bile acid metabolism in parenchymal liver cell disease. Clin Gastroenterol. 1977 Jan;6(1):25–43. [PubMed] [Google Scholar]
  83. Watts J. M., Jablonski P., Toouli J. The effect of added bran to the diet on the saturation of bilein people without gallstones. Am J Surg. 1978 Mar;135(3):321–324. doi: 10.1016/0002-9610(78)90059-4. [DOI] [PubMed] [Google Scholar]
  84. Wechsler J. G., Swobodnik W., Wenzel H., Heuchemer T., Nebelung W., Hutt V., Ditschuneit H. Ballaststoffe vom Typ Weizenkleie senken Lithogenität der Galle. Dtsch Med Wochenschr. 1984 Aug 24;109(34):1284–1288. doi: 10.1055/s-2008-1069364. [DOI] [PubMed] [Google Scholar]
  85. Whiting M. J., Watts JMcK Supersaturated bile from obese patients without gallstones supports cholesterol crystal growth but not nucleation. Gastroenterology. 1984 Feb;86(2):243–248. [PubMed] [Google Scholar]
  86. Wicks A. C., Yeates J., Heaton K. W. Bran and bile: time-course of changes in normal young men given a standard dose. Scand J Gastroenterol. 1978;13(3):289–292. doi: 10.3109/00365527809179822. [DOI] [PubMed] [Google Scholar]
  87. Wynder E. L., Reddy B. S. Metabolic epidemiology of colorectal cancer. Cancer. 1974 Sep;34(3):suppl–suppl:806. doi: 10.1002/1097-0142(197409)34:3+<801::aid-cncr2820340703>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  88. van Berge Henegouwen G. P., van der Werf S. D., Ruben A. T. Fatty acid composition of phospholipids in bile in man: promoting effect of deoxycholate on arachidonate. Clin Chim Acta. 1987 May 29;165(1):27–37. doi: 10.1016/0009-8981(87)90215-4. [DOI] [PubMed] [Google Scholar]
  89. van der Linden W., Bergman F. An analysis of data on human hepatic bile. Relationship between main bile components, serum cholesterol and serum triglycerides. Scand J Clin Lab Invest. 1977 Dec;37(8):741–747. doi: 10.3109/00365517709101859. [DOI] [PubMed] [Google Scholar]
  90. van der Werf S. D., Huijbregts A. W., Lamers H. L., van Berge Henegouwen G. P., van Tongeren J. H. Age dependent differences in human bile acid metabolism and 7 alpha-dehydroxylation. Eur J Clin Invest. 1981 Dec;11(6):425–431. doi: 10.1111/j.1365-2362.1981.tb02009.x. [DOI] [PubMed] [Google Scholar]
  91. van der Werf S. D., Nagengast F. M., van Berge Henegouwen G. P., Huijbregts A. W., van Tongeren J. H. Colonic absorption of secondary bile-acids in patients with adenomatous polyps and in matched controls. Lancet. 1982 Apr 3;1(8275):759–762. doi: 10.1016/s0140-6736(82)91810-4. [DOI] [PubMed] [Google Scholar]
  92. van der Werf S. D., Nagengast F. M., van Berge Henegouwen G. P., Huijbregts A. W., van Tongeren J. H. Intracolonic environment and the presence of colonic adenomas in man. Gut. 1983 Oct;24(10):876–880. doi: 10.1136/gut.24.10.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. van der Werf S. D., van Berge Henegouwen G. P. Biliary bile acid composition and cholesterol saturation. Gastroenterology. 1983 May;84(5 Pt 1):1074–1077. [PubMed] [Google Scholar]

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