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. 1988 May;29(5):665–668. doi: 10.1136/gut.29.5.665

Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue.

B S Ramakrishna 1, V I Mathan 1
PMCID: PMC1433637  PMID: 2840363

Abstract

In 10 southern Indian patients with tropical sprue, in vivo dialysis showed a defect of absorption of water and sodium from the rectum, when compared with 11 healthy volunteers. Sodium-potassium-ATPase activity, measured in homogenates of rectal biopsies, was significantly diminished in patients with sprue. Magnesium-ATPase and alkaline phosphatase were normal in biopsy homogenates. Decreased activity of colonic sodium-potassium-ATPase may contribute to diarrhoea in some patients with tropical sprue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Candy D. C., Larcher V. F., Cameron D. J., Norman A. P., Tripp J. H., Milla P. J., Pincott J. R., Harries J. T. Lethal familial protracted diarrhoea. Arch Dis Child. 1981 Jan;56(1):15–23. doi: 10.1136/adc.56.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Charney A. N., Donowitz M. Functional significance of intestinal Na+-K+-ATPase: in vivo ouabain inhibition. Am J Physiol. 1978 Jun;234(6):E629–E636. doi: 10.1152/ajpendo.1978.234.6.E629. [DOI] [PubMed] [Google Scholar]
  3. Dorai D. T., Bachhawat B. K. Purification and properties of brain alkaline phosphatase. J Neurochem. 1977 Sep;29(3):503–512. doi: 10.1111/j.1471-4159.1977.tb10699.x. [DOI] [PubMed] [Google Scholar]
  4. Edmonds C. J. Absorption of sodium and water by human rectum measured by a dialysis method. Gut. 1971 May;12(5):356–362. doi: 10.1136/gut.12.5.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. McNeil N. I., Cummings J. H., James W. P. Short chain fatty acid absorption by the human large intestine. Gut. 1978 Sep;19(9):819–822. doi: 10.1136/gut.19.9.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Quigley J. P., Gotterer G. S. Distribution of (Na+-K+)-stimulated ATPase activity in rat intestinal mucosa. Biochim Biophys Acta. 1969 Apr;173(3):456–468. doi: 10.1016/0005-2736(69)90010-8. [DOI] [PubMed] [Google Scholar]
  8. Rachmilewitz D., Karmeli F., Sharon P. Decreased colonic Na-K-ATPase activity in active ulcerative colitis. Isr J Med Sci. 1984 Aug;20(8):681–684. [PubMed] [Google Scholar]
  9. Ramakrishna B. S., Mathan V. I. Role of bacterial toxins, bile acids, and free fatty acids in colonic water malabsorption in tropical sprue. Dig Dis Sci. 1987 May;32(5):500–505. doi: 10.1007/BF01296033. [DOI] [PubMed] [Google Scholar]
  10. Ramakrishna B. S., Mathan V. I. Water and electrolyte absorption by the colon in tropical sprue. Gut. 1982 Oct;23(10):843–846. doi: 10.1136/gut.23.10.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Regarding the definition of tropical sprue. Gastroenterology. 1970 May;58(5):717–721. [PubMed] [Google Scholar]
  12. Tripp J. H., Muller D. P., Harries J. T. Mucosal (Na+-K+)-ATPase and adenylate cyclase activities in children with toddler diarrhea and the postenteritis syndrome. Pediatr Res. 1980 Dec;14(12):1382–1386. doi: 10.1203/00006450-198012000-00025. [DOI] [PubMed] [Google Scholar]

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