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. 1988 May;29(5):631–635. doi: 10.1136/gut.29.5.631

Cisapride restores the decreased lower oesophageal sphincter pressure in reflux patients.

P Ceccatelli 1, J Janssens 1, G Vantrappen 1, S Cucchiara 1
PMCID: PMC1433641  PMID: 3294123

Abstract

The effect of the new prokinetic drug cisapride on the resting lower oesophageal sphincter pressure and on the strength of peristaltic contractions was studied in 10 healthy controls and in 10 reflux patients with abnormally low (less than 10 mm Hg) basal lower oesophageal sphincter pressure. A slow intravenous injection of cisapride 10 mg significantly increased the sphincter pressure in the controls but even more in the patients in whom it almost doubled the resting lower oesophageal sphincter pressure of 8.7 (0.5) mm Hg to between 15 and 20 mm Hg for at least 90 min. Results are expressed as mean (SE). Cisapride also significantly increased the amplitude of peristaltic contractions in controls and reflux patients. Therefore, cisapride might be useful in the treatment of reflux.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Affolter H. Pressure characteristics of reflux esophagitis. Helv Med Acta. 1967 May;33(5):395–402. [PubMed] [Google Scholar]
  2. Ahtaridis G., Snape W. J., Jr, Cohen S. Lower esophageal sphincter pressure as an index of gastroesophageal acid reflux. Dig Dis Sci. 1981 Nov;26(11):993–998. doi: 10.1007/BF01314761. [DOI] [PubMed] [Google Scholar]
  3. Dilawari J. B., Misiewicz J. J. Action of oral metoclopramide on the gastrooesophageal junction in man. Gut. 1973 May;14(5):380–382. [PMC free article] [PubMed] [Google Scholar]
  4. Dodds W. J., Dent J., Hogan W. J., Helm J. F., Hauser R., Patel G. K., Egide M. S. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982 Dec 16;307(25):1547–1552. doi: 10.1056/NEJM198212163072503. [DOI] [PubMed] [Google Scholar]
  5. Dodds W. J., Hogan W. J., Miller W. N. Reflux esophagitis. Am J Dig Dis. 1976 Jan;21(1):49–67. doi: 10.1007/BF01074140. [DOI] [PubMed] [Google Scholar]
  6. Farrell R. L., Roling G. T., Castell D. O. Stimulation of the incompetent lower esophageal sphincter. A possible advance in therapy of heartburn. Am J Dig Dis. 1973 Aug;18(8):646–650. doi: 10.1007/BF01072035. [DOI] [PubMed] [Google Scholar]
  7. Haddad J. K. Relation of gastroesophageal reflux to yield sphincter pressures. Gastroenterology. 1970 Feb;58(2):175–184. [PubMed] [Google Scholar]
  8. Heitmann P., Möller N. The effect of metoclopramide on the gastroesophageal junctional zone and the distal esophagus in man. Scand J Gastroenterol. 1970;5(7):620–626. [PubMed] [Google Scholar]
  9. Helm J. F., Dodds W. J., Pelc L. R., Palmer D. W., Hogan W. J., Teeter B. C. Effect of esophageal emptying and saliva on clearance of acid from the esophagus. N Engl J Med. 1984 Feb 2;310(5):284–288. doi: 10.1056/NEJM198402023100503. [DOI] [PubMed] [Google Scholar]
  10. Helm J. F., Dodds W. J., Riedel D. R., Teeter B. C., Hogan W. J., Arndorfer R. C. Determinants of esophageal acid clearance in normal subjects. Gastroenterology. 1983 Sep;85(3):607–612. [PubMed] [Google Scholar]
  11. Knuff T. E., Benjamin S. B., Worsham G. F., Hancock J. E., Castell D. O. Histologic evaluation of chronic gastroesophageal reflux. An evaluation of biopsy methods and diagnostic criteria. Dig Dis Sci. 1984 Mar;29(3):194–201. doi: 10.1007/BF01296251. [DOI] [PubMed] [Google Scholar]
  12. Koch G. G. The use of non-parametric methods in the statistical analysis of the two-period change-over design. Biometrics. 1972 Jun;28(2):577–584. [PubMed] [Google Scholar]
  13. McCallum R. W., Kline M. M., Curry N., Sturdevant R. A. Comparative effects of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology. 1975 May;68(5 Pt 1):1114–1118. [PubMed] [Google Scholar]
  14. Miller W. N., Ganeshappa K. P., Dodds W. J., Hogan W. J., Barreras R. F., Arndorfer R. C. Effect of bethanechol on gastroesophageal reflux. Am J Dig Dis. 1977 Mar;22(3):230–234. doi: 10.1007/BF01072281. [DOI] [PubMed] [Google Scholar]
  15. Olsen A. M., Schlegel J. F. Motility disturbances caused by esophagitis. J Thorac Cardiovasc Surg. 1965 Nov;50(5):607–612. [PubMed] [Google Scholar]
  16. Pope C. E., 2nd A dynamic test of sphincter strength: its application to the lower esophageal sphincter. Gastroenterology. 1967 May;52(5):779–786. [PubMed] [Google Scholar]
  17. Richter J. E., Castell D. O. Gastroesophageal reflux. Pathogenesis, diagnosis, and therapy. Ann Intern Med. 1982 Jul;97(1):93–103. doi: 10.7326/0003-4819-97-1-93. [DOI] [PubMed] [Google Scholar]
  18. Russell C. O., Pope C. E., 2nd, Gannan R. M., Allen F. D., Velasco N., Hill L. D. Does surgery correct esophageal motor dysfunction in gastroesophageal reflux. Ann Surg. 1981 Sep;194(3):290–296. doi: 10.1097/00000658-198109000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schuurkes J. A., Van Nueten J. M., Van Daele P. G., Reyntjens A. J., Janssen P. A. Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharmacol Exp Ther. 1985 Sep;234(3):775–783. [PubMed] [Google Scholar]
  20. Smout A. J., Bogaard J. W., Grade A. C., ten Thije O. J., Akkermans L. M., Wittebol P. Effects of cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man. Gut. 1985 Mar;26(3):246–251. doi: 10.1136/gut.26.3.246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Tolin R. D., Malmud L. S., Reilley J., Fisher R. S. Esophageal scintigraphy to quantitate esophageal transit (quantitation of esophageal transit). Gastroenterology. 1979 Jun;76(6):1402–1408. [PubMed] [Google Scholar]
  22. Wallin L., Kruse-Andersen S., Madsen T., Boesby S. Effect of cisapride on the gastro-oesophageal function in normal human subjects. Digestion. 1987;37(3):160–165. doi: 10.1159/000199494. [DOI] [PubMed] [Google Scholar]
  23. Welch R. W., Luckmann K., Ricks P., Drake S. T., Bannayan G., Owensby L. Lower esophageal sphincter pressure in histologic esophagitis. Dig Dis Sci. 1980 Jun;25(6):420–426. doi: 10.1007/BF01395505. [DOI] [PubMed] [Google Scholar]

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