Abstract
Kinetics of [24-14C] cholic acid and [24-14C] chenodeoxycholic acid and biliary lipid composition were determined in patients with chronic alcoholic pancreatitis with (n = 8) and without (n = 8) steatorrhoea. Pool sizes, syntheses and fractional catabolic rates of the two bile acids were not significantly different from corresponding values in healthy controls. Biliary lipid composition was normal in patients without steatorrhoea. Patients with steatorrhoea, on the other hand, had lower cholesterol saturation of bile than corresponding controls. This is probably because of malabsorption of cholesterol.
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Selected References
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- Abrams J. J., Ginsberg H., Grundy S. M. Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. Diabetes. 1982 Oct;31(10):903–910. doi: 10.2337/diab.31.10.903. [DOI] [PubMed] [Google Scholar]
- Angelin B., Einarsson K., Ewerth S., Leijd B. Biliary lipid composition in patients with porta cirrhosis of the liver. Scand J Gastroenterol. 1980;15(7):849–852. doi: 10.3109/00365528009181540. [DOI] [PubMed] [Google Scholar]
- Angelin B., Einarsson K., Hellström K. Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects. Gut. 1976 Jun;17(6):420–425. doi: 10.1136/gut.17.6.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carey M. C. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res. 1978 Nov;19(8):945–955. [PubMed] [Google Scholar]
- Einarsson K., Nilsell K., Leijd B., Angelin B. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med. 1985 Aug 1;313(5):277–282. doi: 10.1056/NEJM198508013130501. [DOI] [PubMed] [Google Scholar]
- Fausa O., Skålhegg B. A. Quantitative determination of bile acids and their conjugates using thin-layer chromatography and a purified 3alpha-hydroxysteroid dehydrogenase. Scand J Gastroenterol. 1974;9(3):249–254. [PubMed] [Google Scholar]
- LUNDH G. Pancreatic exocrine function in neoplastic and inflammatory disease; a simple and reliable new test. Gastroenterology. 1962 Mar;42:275–280. [PubMed] [Google Scholar]
- Lagerlöf H. O., Schütz H. B., Holmer S. A secretin test with high doses of secretin and correction for incomplete recovery of duodenal juice. Gastroenterology. 1967 Jan;52(1):67–77. [PubMed] [Google Scholar]
- Regan P. T., Malagelada J. R., Dimagno E. P., Go V. L. Reduced intraluminal bile acid concentrations and fat maldigestion in pancreatic insufficiency: correction by treatment. Gastroenterology. 1979 Aug;77(2):285–289. [PubMed] [Google Scholar]
- Roda A., Festi D., Sama C., Mazzella G., Alini R., Roda E., Barbara L. Enzymatic determination of cholesterol in bile. Clin Chim Acta. 1975 Nov 3;64(3):337–341. doi: 10.1016/0009-8981(75)90364-2. [DOI] [PubMed] [Google Scholar]
- Rouser G., Fkeischer S., Yamamoto A. Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids. 1970 May;5(5):494–496. doi: 10.1007/BF02531316. [DOI] [PubMed] [Google Scholar]
