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. 1988 Jun;29(6):778–781. doi: 10.1136/gut.29.6.778

Frequency of pancreatitis in fulminant hepatic failure using isoenzyme markers.

R J Ede 1, K P Moore 1, W J Marshall 1, R Williams 1
PMCID: PMC1433740  PMID: 2454877

Abstract

Evidence of acute pancreatitis was sought in 35 patients with fulminant hepatic failure. Total amylase was raised in 22 patients and isoenzyme separation showed a distinct P3 isoenzyme (indicative of pancreatitis) in 14. In four patients with marked hyperamylasaemia (greater than 1000 U/l) the predominant isoenzyme was the salivary fraction. Pancreatic lipase was abnormally raised (greater than 200 U/l) in 34 patients but exceeded 1000 U/l in 12 of the 14 with a distinct P3 isoenzyme. Thus on the basis of a distinct P3 isoenzyme of amylase and an increased pancreatic lipase activity evidence of pancreatitis was found in 34% of patients in this series.

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Selected References

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  1. Benjamin D. R., Kenny M. A. Clinical value of amylase isoenzyme determinations. Am J Clin Pathol. 1974 Dec;62(6):752–758. doi: 10.1093/ajcp/62.6.752. [DOI] [PubMed] [Google Scholar]
  2. Berk J. E., Fridhandler L., Ness R. L. Amylase and isoamylase activities in renal insufficiency. Ann Intern Med. 1979 Mar;90(3):351–353. doi: 10.7326/0003-4819-90-3-351. [DOI] [PubMed] [Google Scholar]
  3. Berk J. E., Shimamura J., Fridhandler L. Amylase changes in disorders of the lung. Gastroenterology. 1978 Jun;74(6):1313–1317. [PubMed] [Google Scholar]
  4. Bihari D., Gimson A. E., Lindridge J., Williams R. Lactic acidosis in fulminant hepatic failure. Some aspects of pathogenesis and prognosis. J Hepatol. 1985;1(4):405–416. doi: 10.1016/s0168-8278(85)80778-9. [DOI] [PubMed] [Google Scholar]
  5. Bouwman D. L., Altshuler J., Weaver D. W. Hyperamylasemia: a result of intracranial bleeding. Surgery. 1983 Aug;94(2):318–323. [PubMed] [Google Scholar]
  6. Collins R. E., Frost S. J., Spittlehouse K. E. The P3 iso-enzyme of serum amylase in the management of patients with acute pancreatitis. Br J Surg. 1982 Jul;69(7):373–375. doi: 10.1002/bjs.1800690705. [DOI] [PubMed] [Google Scholar]
  7. Geokas M. C., Olsen H., Swanson V., Rinderknecht H. The association of viral hepatitis and acute pancreatitis. Calif Med. 1972 Sep;117(3):1–7. [PMC free article] [PubMed] [Google Scholar]
  8. Gove C. D., Wardle E. N., Williams R. Circulating lysosomal enzymes and acute hepatic necrosis. J Clin Pathol. 1981 Jan;34(1):13–16. doi: 10.1136/jcp.34.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ham J. M., Fitzpatrick P. Acute pancreatitis in patients with acute hepatic failure. Am J Dig Dis. 1973 Dec;18(12):1079–1083. doi: 10.1007/BF01076525. [DOI] [PubMed] [Google Scholar]
  10. Leclerc P., Forest J. C. Variations in amylase isoenzymes and lipase during acute pancreatitis, and in other disorders causing hyperamylasemia. Clin Chem. 1983 Jun;29(6):1020–1023. [PubMed] [Google Scholar]
  11. Lefer A. M. The role of lysosomes in circulatory shock. Life Sci. 1976 Dec 15;19(12):1803–1809. doi: 10.1016/0024-3205(76)90111-9. [DOI] [PubMed] [Google Scholar]
  12. Legaz M. E., Kenny M. A. Electrophoretic amylase fractionation as an aid in diagnosis of pancreatic disease. Clin Chem. 1976 Jan;22(1):57–62. [PubMed] [Google Scholar]
  13. Parbhoo S. P., Welch J., Sherlock S. Acute pancreatitis in patients with fulminant hepatic failure. Gut. 1973 May;14(5):428–428. [PubMed] [Google Scholar]
  14. Sanfey H., Bulkley G. B., Cameron J. L. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann Surg. 1984 Oct;200(4):405–413. doi: 10.1097/00000658-198410000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Standfield N. J., Kakkar V. V. Prostaglandins and acute pancreatitis--experimental and clinical studies. Br J Surg. 1983 Oct;70(10):573–576. doi: 10.1002/bjs.1800701002. [DOI] [PubMed] [Google Scholar]
  16. Toomasian J. M., Badin T., Elliott M. P., Pezzlo F., Gazzaniga A. B. Effects of hepatic autologous lysosomal enzymes on rat lungs. Surg Forum. 1976;27(62):173–175. [PubMed] [Google Scholar]
  17. Trey C., Davidson C. S. The management of fulminant hepatic failure. Prog Liver Dis. 1970;3:282–298. [PubMed] [Google Scholar]
  18. Wands J. R., Salyer D. C., Boitnott J. K., Maddrey W. C. Fulminant hepatitis complicated by pancreatitis. Johns Hopkins Med J. 1973 Sep;133(3):156–160. [PubMed] [Google Scholar]
  19. Warshaw A. L., Lee K. H. Characteristic alterations of serum isoenzymes of amylase in diseases of liver, pancreas, salivary gland, lung, and genitalia. J Surg Res. 1977 Apr;22(4):362–369. doi: 10.1016/0022-4804(77)90158-5. [DOI] [PubMed] [Google Scholar]
  20. Wilkinson S. P., Moodie H., Arroyo V. A., Williams R. Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage. J Clin Pathol. 1977 Feb;30(2):141–143. doi: 10.1136/jcp.30.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]

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