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. 1988 Jun;29(6):821–825. doi: 10.1136/gut.29.6.821

Can 111indium autologous mixed leucocyte scanning accurately assess disease extent and activity in Crohn's disease?

R H Park 1, J H McKillop 1, A Duncan 1, J F MacKenzie 1, R I Russell 1
PMCID: PMC1433744  PMID: 3133287

Abstract

111Indium autologous mixed leucocyte scanning has recently been used for the investigation of Crohn's disease. Nineteen patients had indium scans to assess disease extent and activity. The scans were compared with conventional imaging techniques and indices of disease activity including clinical scores, ESR, CRP, and GI protein loss. In five patients with active disease the scans were negative and overall there was poor correlation between the scan scores and the other indices of disease activity. Indium scanning correctly located extent of disease in only 58% of patients. 111Indium mixed leucocyte scanning may be more suited for the assessment of disease extent and activity in severely ill patients with Crohn's disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andre C., Descos L., Landais P., Fermanian J. Assessment of appropriate laboratory measurements to supplement the Crohn's disease activity index. Gut. 1981 Jul;22(7):571–574. doi: 10.1136/gut.22.7.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Best W. R., Becktel J. M., Singleton J. W., Kern F., Jr Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439–444. [PubMed] [Google Scholar]
  3. Buxton-Thomas M. S., Dickinson R. J., Maltby P., Hunter J. O., Wraight E. P. Evaluation of indium scintigraphy in patients with active inflammatory bowel disease. Gut. 1984 Dec;25(12):1372–1375. doi: 10.1136/gut.25.12.1372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Datz F. L., Bedont R. A., Baker W. J., Alazraki N. P., Taylor A., Jr No difference in sensitivity for occult infection between tropolone- and oxine-labeled indium-111 leukocytes. J Nucl Med. 1985 May;26(5):469–473. [PubMed] [Google Scholar]
  5. Fagan E. A., Dyck R. F., Maton P. N., Hodgson H. J., Chadwick V. S., Petrie A., Pepys M. B. Serum levels of C-reactive protein in Crohn's disease and ulcerative colitis. Eur J Clin Invest. 1982 Aug;12(4):351–359. doi: 10.1111/j.1365-2362.1982.tb02244.x. [DOI] [PubMed] [Google Scholar]
  6. Harvey R. F., Bradshaw J. M. A simple index of Crohn's-disease activity. Lancet. 1980 Mar 8;1(8167):514–514. doi: 10.1016/s0140-6736(80)92767-1. [DOI] [PubMed] [Google Scholar]
  7. Logan R. F., Gillon J., Ferrington C., Ferguson A. Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel. Gut. 1981 May;22(5):383–387. doi: 10.1136/gut.22.5.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Saverymuttu S. H., Camilleri M., Rees H., Lavender J. P., Hodgson H. J., Chadwick V. S. Indium 111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and fecal indium 111-granulocyte excretion. Gastroenterology. 1986 May;90(5 Pt 1):1121–1128. doi: 10.1016/0016-5085(86)90376-8. [DOI] [PubMed] [Google Scholar]
  9. Saverymuttu S. H. Clinical remission in Crohn's disease--assessment using faecal 111In granulocyte excretion. Digestion. 1986;33(2):74–79. doi: 10.1159/000199277. [DOI] [PubMed] [Google Scholar]
  10. Saverymuttu S. H., Lavender J. P., Hodgson H. J., Chadwick V. S. Assessment of disease activity in inflammatory bowel disease: a new approach using 111In granulocyte scanning. Br Med J (Clin Res Ed) 1983 Dec 10;287(6407):1751–1753. doi: 10.1136/bmj.287.6407.1751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Saverymuttu S. H., Peters A. M., Hodgson H. J., Chadwick V. S., Lavender J. P. Indium-111 autologous leucocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease. Br Med J (Clin Res Ed) 1982 Jul 24;285(6337):255–257. doi: 10.1136/bmj.285.6337.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Saverymuttu S. H., Peters A. M., Lavender J. P., Pepys M. B., Hodgson H. J., Chadwick V. S. Quantitative fecal indium 111-labeled leukocyte excretion in the assessment of disease in Crohn's disease. Gastroenterology. 1983 Dec;85(6):1333–1339. [PubMed] [Google Scholar]
  13. Segal A. W., Ensell J., Munro J. M., Sarner M. Indium-111 tagged leucocytes in the diagnosis of inflammatory bowel disease. Lancet. 1981 Aug 1;2(8240):230–232. doi: 10.1016/s0140-6736(81)90477-3. [DOI] [PubMed] [Google Scholar]
  14. Stein D. T., Gray G. M., Gregory P. B., Anderson M., Goodwin D. A., McDougall I. R. Location and activity of ulcerative and Crohn's colitis by indium 111 leukocyte scan. A prospective comparison study. Gastroenterology. 1983 Feb;84(2):388–393. [PubMed] [Google Scholar]
  15. van Tongeren J. H., Reichert W. J. Demonstration of protein-losing gastroenteropathy. The quantitative estimation of gastrointestinal protein loss, using 51Cr-labelled plasma proteins. Clin Chim Acta. 1966 Jul;14(1):42–48. doi: 10.1016/0009-8981(66)90062-3. [DOI] [PubMed] [Google Scholar]

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