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. 1986 Sep;27(9):1014–1017. doi: 10.1136/gut.27.9.1014

Bladder smooth muscle dysfunction in patients with irritable bowel syndrome.

P J Whorwell, E W Lupton, D Erduran, K Wilson
PMCID: PMC1433792  PMID: 3758813

Abstract

Urodynamic studies were carried out on 30 patients with irritable bowel syndrome and 30 matched controls. Fifty per cent of the irritable bowel patients compared with only 13% of the control group had evidence of bladder dysfunction (p = 0.006). In the irritable bowel group detrusor instability was observed in 10 patients compared with only one control subject (p = 0.008). A steep cystometrogram occurred in five irritable bowel patients and three controls (NS). Detrusor instability was most common in patients with a bowel habit characterised by alternating constipation and diarrhoea. This is the first study to provide objective evidence that patients with irritable bowel syndrome may have a disorder of smooth muscle or its innervation that is not confined to the gastrointestinal system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bates C. P. Continence and incontinence. A clinical study of the dynamics of voiding and of the sphincter mechanism. Ann R Coll Surg Engl. 1971 Jul;49(1):18–35. [PMC free article] [PubMed] [Google Scholar]
  2. Bates C. P., Corney C. E. Synchronous cine-pressure-flow cystography: a method of routine urodynamic investigation. Br J Radiol. 1971 Jan;44(517):44–50. doi: 10.1259/0007-1285-44-517-44. [DOI] [PubMed] [Google Scholar]
  3. Burns T. W. Colonic motility in the irritable bowel syndrome. Arch Intern Med. 1980 Feb;140(2):247–251. [PubMed] [Google Scholar]
  4. Drossman D. A., Sandler R. S., McKee D. C., Lovitz A. J. Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction. Gastroenterology. 1982 Sep;83(3):529–534. [PubMed] [Google Scholar]
  5. Murney R. G., Jr, Winship D. H. The irritable colon syndrome. Clin Gastroenterol. 1982 Sep;11(3):563–592. [PubMed] [Google Scholar]
  6. Ritchie J. The irritable bowel syndrome. Part II: manometric and cineradiographic studies. Clin Gastroenterol. 1977 Sep;6(3):622–641. [PubMed] [Google Scholar]
  7. Taylor I., Darby C., Hammond P., Basu P. Is there a myoelectrical abnormality in the irritable colon syndrome? Gut. 1978 May;19(5):391–395. doi: 10.1136/gut.19.5.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Thompson D. G., Laidlow J. M., Wingate D. L. Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet. 1979 Dec 22;2(8156-8157):1321–1323. doi: 10.1016/s0140-6736(79)92811-3. [DOI] [PubMed] [Google Scholar]
  9. Thompson W. G., Heaton K. W. Functional bowel disorders in apparently healthy people. Gastroenterology. 1980 Aug;79(2):283–288. [PubMed] [Google Scholar]
  10. Thompson W. G. The irritable bowel. Gut. 1984 Mar;25(3):305–320. doi: 10.1136/gut.25.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Warwick R. T. Observations on the function and dysfunction of the sphincter and detrusor mechanisms. Urol Clin North Am. 1979 Feb;6(1):13–30. [PubMed] [Google Scholar]
  12. Whorwell P. J., Clouter C., Smith C. L. Oesophageal motility in the irritable bowel syndrome. Br Med J (Clin Res Ed) 1981 Apr 4;282(6270):1101–1102. doi: 10.1136/bmj.282.6270.1101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Whorwell P. J., McCallum M., Creed F. H., Roberts C. T. Non-colonic features of irritable bowel syndrome. Gut. 1986 Jan;27(1):37–40. doi: 10.1136/gut.27.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]

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