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. 1986 Sep;27(9):1058–1061. doi: 10.1136/gut.27.9.1058

Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer.

C W Howden, D B Jones, D W Burget, R H Hunt
PMCID: PMC1433799  PMID: 3758819

Abstract

Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. The aim was to investigate the relationship between antisecretory effect in the two populations. There was a significant correlation between effect in patients and normal subjects for suppression of 24 hour intragastric acidity (r = 0.732; p = 0.0068), nocturnal intragastric acidity (r = 0.861; p = 0.0033) and nocturnal acid output (r = 0.964; p = 0.0069). The regression lines for 24 hour and nocturnal acidity were very similar. The expected antisecretory effect of a particular dosage regimen in patients with duodenal ulcer can be predicted mathematically from data derived from studies in normal volunteers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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