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. 1986 Oct;27(10):1161–1168. doi: 10.1136/gut.27.10.1161

Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides.

J J Rumessen, E Gudmand-Høyer
PMCID: PMC1433856  PMID: 3781328

Abstract

The capacity to absorb fructose in 10 healthy adults was investigated by means of hydrogen breath analysis. Fructose absorption was quantified with lactulose standards. Significant hydrogen production (greater than or equal to 20 ppm rise of breath hydrogen) was found after challenge with 10% solutions of 50, 37.5, 25, 20, and 15 g fructose in eight, seven, five, four and one subjects, respectively. One subject showed malabsorption after a 10 g dose and possibly also 5 g fructose. In contrast, no malabsorption could be detected in any of the 10 subjects after ingestion of 100 g, 75 g, or 50 g sucrose or a mixture of 50 g glucose and 50 g fructose. After ingestion of mixtures of 50 g fructose +25 g glucose and 50 g fructose +12.5 g glucose malabsorption was present in three and seven subjects, respectively. Symptoms during all challenges were mild, or absent. It is concluded that in the healthy state the absorption capacity of fructose given alone ranges from less than 5 g to more than 50 g. The absorption capacity of fructose given as sucrose is much higher. Glucose stimulates fructose uptake in a dose dependent fashion. The possible existence of more than one intestinal transport system for fructose is considered. The elucidation of the clinical relevance of the findings is important.

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Selected References

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  1. Anderson I. H., Levine A. S., Levitt M. D. Incomplete absorption of the carbohydrate in all-purpose wheat flour. N Engl J Med. 1981 Apr 9;304(15):891–892. doi: 10.1056/NEJM198104093041507. [DOI] [PubMed] [Google Scholar]
  2. Andersson D. E., Nygren A. Four cases of long-standing diarrhoea and colic pains cured by fructose-free diet--a pathogenetic discussion. Acta Med Scand. 1978;203(1-2):87–92. doi: 10.1111/j.0954-6820.1978.tb14836.x. [DOI] [PubMed] [Google Scholar]
  3. Barnes G., McKellar W., Lawrance S. Detection of fructose malabsorption by breath hydrogen test in a child with diarrhea. J Pediatr. 1983 Oct;103(4):575–577. doi: 10.1016/s0022-3476(83)80588-5. [DOI] [PubMed] [Google Scholar]
  4. Barr R. G., Watkins J. B., Perman J. A. Mucosal function and breath hydrogen excretion: comparative studies in the clinical evaluation of children with nonspecific abdominal complaints. Pediatrics. 1981 Oct;68(4):526–533. [PubMed] [Google Scholar]
  5. Bond J. H., Jr, Levitt M. D. Use of pulmonary hydrogen (H 2 ) measurements to quantitate carbohydrate absorption. Study of partially gastrectomized patients. J Clin Invest. 1972 May;51(5):1219–1225. doi: 10.1172/JCI106916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bond J. H., Levitt M. D. Quantitative measurement of lactose absorption. Gastroenterology. 1976 Jun;70(6):1058–1062. [PubMed] [Google Scholar]
  7. Brener W., Hendrix T. R., McHugh P. R. Regulation of the gastric emptying of glucose. Gastroenterology. 1983 Jul;85(1):76–82. [PubMed] [Google Scholar]
  8. Cook G. C. Comparison of the absorption and metabolic products of sucrose and its monosaccharides in man. Clin Sci. 1970 Jun;38(6):687–697. doi: 10.1042/cs0380687. [DOI] [PubMed] [Google Scholar]
  9. Crapo P. A., Kolterman O. G., Olefsky J. M. Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care. 1980 Sep-Oct;3(5):575–582. doi: 10.2337/diacare.3.5.575. [DOI] [PubMed] [Google Scholar]
  10. Elias E., Gibson G. J., Greenwood L. F., Hunt J. N., Tripp J. H. The slowing of gastric emptying by monosaccharides and disaccharides in test meals. J Physiol. 1968 Feb;194(2):317–326. doi: 10.1113/jphysiol.1968.sp008410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GRAY G. M., INGELFINGER F. J. INTESTINAL ABSORPTION OF SUCROSE IN MAN: THE SITE OF HYDROLYSIS AND ABSORPTION. J Clin Invest. 1965 Mar;44:390–398. doi: 10.1172/JCI105152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gracey M., Burke V., Anderson C. A. Association of monosaccharide malabsorption with abnormal small-intestinal flora. Lancet. 1969 Aug 16;2(7616):384–385. doi: 10.1016/s0140-6736(69)92734-2. [DOI] [PubMed] [Google Scholar]
  13. Gracey M., Burke V., Oshin A. Active intestinal transport of D-fructose. Biochim Biophys Acta. 1972 May 9;266(2):397–406. doi: 10.1016/0005-2736(72)90096-x. [DOI] [PubMed] [Google Scholar]
  14. Gray G. M., Ingelfinger F. J. Intestinal absorption of sucrose in man: interrelation of hydrolysis and monosaccharide product absorption. J Clin Invest. 1966 Mar;45(3):388–398. doi: 10.1172/JCI105354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Groen J. THE ABSORPTION OF HEXOSES FROM THE UPPER PART OF THE SMALL INTESTINE IN MAN. J Clin Invest. 1937 Mar;16(2):245–255. doi: 10.1172/JCI100854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gudmand-Hoyer E., Simony K. Individual sensitivity to lactose in lactose malabsorption. Am J Dig Dis. 1977 Mar;22(3):177–181. doi: 10.1007/BF01072273. [DOI] [PubMed] [Google Scholar]
  17. HARDINGE M. G., SWARNER J. B., CROOKS H. CARBOHYDRATES IN FOODS. J Am Diet Assoc. 1965 Mar;46:197–204. [PubMed] [Google Scholar]
  18. HOLDSWORTH C. D., DAWSON A. M. ABSORPTION OF FRUCTOSE IN MAN. Proc Soc Exp Biol Med. 1965 Jan;118:142–145. doi: 10.3181/00379727-118-29780. [DOI] [PubMed] [Google Scholar]
  19. HOLDSWORTH C. D., DAWSON A. M. THE ABSORPTION OF MONOSACCHARIDES IN MAN. Clin Sci. 1964 Dec;27:371–379. [PubMed] [Google Scholar]
  20. Holloway P. A., Parsons D. S. Absorption and metabolism of fructose by rat jejunum. Biochem J. 1984 Aug 15;222(1):57–64. doi: 10.1042/bj2220057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Kneepkens C. M., Vonk R. J., Fernandes J. Incomplete intestinal absorption of fructose. Arch Dis Child. 1984 Aug;59(8):735–738. doi: 10.1136/adc.59.8.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kotler D. P., Holt P. R., Rosensweig N. S. Modification of the breath hydrogen test: increased sensitivity for the detection of carbohydrate malabsorption. J Lab Clin Med. 1982 Nov;100(5):798–805. [PubMed] [Google Scholar]
  23. Macrae A. R., Neudoerffer T. S. Support for the existence of an active transport mechanism of fructose in the rat. Biochim Biophys Acta. 1972 Oct 23;288(1):137–144. doi: 10.1016/0005-2736(72)90231-3. [DOI] [PubMed] [Google Scholar]
  24. Metz G., Jenkins D. J., Peters T. J., Newman A., Blendis L. M. Breath hydrogen as a diagnostic method for hypolactasia. Lancet. 1975 May 24;1(7917):1155–1157. doi: 10.1016/s0140-6736(75)93135-9. [DOI] [PubMed] [Google Scholar]
  25. Ramaswamy K., Malathi P., Caspary W. F., Crane R. K. Studies on the transport of glucose from disaccharides by hamster small intestine in vitro. II. Characteristics of the disaccharidase-related transport system. Biochim Biophys Acta. 1974 Apr 12;345(1):39–48. doi: 10.1016/0005-2736(74)90243-0. [DOI] [PubMed] [Google Scholar]
  26. Ravich W. J., Bayless T. M. Carbohydrate absorption and malabsorption. Clin Gastroenterol. 1983 May;12(2):335–356. [PubMed] [Google Scholar]
  27. Ravich W. J., Bayless T. M., Thomas M. Fructose: incomplete intestinal absorption in humans. Gastroenterology. 1983 Jan;84(1):26–29. [PubMed] [Google Scholar]
  28. Read N. W., Al-Janabi M. N., Bates T. E., Holgate A. M., Cann P. A., Kinsman R. I., McFarlane A., Brown C. Interpretation of the breath hydrogen profile obtained after ingesting a solid meal containing unabsorbable carbohydrate. Gut. 1985 Aug;26(8):834–842. doi: 10.1136/gut.26.8.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Schneider F., Günther O. Malabsorption-Syndrom infolge Laktasemangels kombiniert mit Fruktoseunverträglichkeit. Dtsch Z Verdau Stoffwechselkr. 1969;29(6):393–400. [PubMed] [Google Scholar]
  30. Schultz S. G., Strecker C. K. Fructose influx across the brush border of rabbit ileum. Biochim Biophys Acta. 1970 Sep 15;211(3):586–588. doi: 10.1016/0005-2736(70)90266-x. [DOI] [PubMed] [Google Scholar]
  31. WHITE L. W., LANDAU B. R. SUGAR TRANSPORT AND FRUCTOSE METABOLISM IN HUMAN INTESTINE IN VITRO. J Clin Invest. 1965 Jul;44:1200–1213. doi: 10.1172/JCI105226. [DOI] [PMC free article] [PubMed] [Google Scholar]

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