Skip to main content
NCBI home page
Gut logoLink to Gut
. 1987 Dec;28(12):1609–1612. doi: 10.1136/gut.28.12.1609

Reduction of colonic motility by intravenous nicardipine in irritable bowel syndrome.

A Prior 1, S R Harris 1, P J Whorwell 1
PMCID: PMC1433931  PMID: 3428688

Abstract

The effect of nicardipine, a new dihydropyridine calcium antagonist, on postprandial colonic motility was assessed in 10 patients with irritable bowel syndrome. Each patient was studied twice receiving intravenously either N saline or nicardipine after a 1000 calorie meal. In the control study there was a significant (p less than 0.01) postprandial increase in the contractile activity of the colon, reaching a peak at approximately 20 minutes. Intravenous nicardipine completely abolished the colonic response, with a significant reduction in the number (p less than 0.005) and amplitude (p less than 0.005) of contractions and of the motility index (p less than 0.025). These results support the need for further studies to evaluate the therapeutic role of nicardipine in the irritable bowel syndrome.

Full text

PDF
1609

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns of motility. Gastroenterology. 1961 Jan;40:1–17. [PubMed] [Google Scholar]
  2. CONNELL A. M., JONES F. A., ROWLANDS E. N. MOTILITY OF THE PELVIC COLON. IV. ABDOMINAL PAIN ASSOCIATED WITH COLONIC HYPERMOTILITY AFTER MEALS. Gut. 1965 Apr;6:105–112. doi: 10.1136/gut.6.2.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Holdstock D. J., Misiewicz J. J. Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer. Gut. 1970 Feb;11(2):100–110. doi: 10.1136/gut.11.2.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Holdstock D. J., Misiewicz J. J., Waller S. L. Observations on the mechanism of abdominal pain. Gut. 1969 Jan;10(1):19–31. doi: 10.1136/gut.10.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Karaki H., Weiss G. B. Calcium channels in smooth muscle. Gastroenterology. 1984 Oct;87(4):960–970. [PubMed] [Google Scholar]
  6. Kerlin P., Zinsmeister A., Phillips S. Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans. Gastroenterology. 1983 Apr;84(4):762–770. [PubMed] [Google Scholar]
  7. Levinson S., Bhasker M., Gibson T. R., Morin R., Snape W. J., Jr Comparison of intraluminal and intravenous mediators of colonic response to eating. Dig Dis Sci. 1985 Jan;30(1):33–39. doi: 10.1007/BF01318368. [DOI] [PubMed] [Google Scholar]
  8. Narducci F., Bassotti G., Gaburri M., Farroni F., Morelli A. Nifedipine reduces the colonic motor response to eating in patients with the irritable colon syndrome. Am J Gastroenterol. 1985 May;80(5):317–319. [PubMed] [Google Scholar]
  9. Narducci F., Bassotti G., Granata M. T., Pelli M. A., Gaburri M., Palumbo R., Morelli A. Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci. 1986 Mar;31(3):241–246. doi: 10.1007/BF01318114. [DOI] [PubMed] [Google Scholar]
  10. Narducci F., Snape W. J., Jr, Battle W. M., London R. L., Cohen S. Increased colonic motility during exposure to a stressful situation. Dig Dis Sci. 1985 Jan;30(1):40–44. doi: 10.1007/BF01318369. [DOI] [PubMed] [Google Scholar]
  11. Prior A., Whorwell P. J. Management of irritable bowel syndrome. Biomed Pharmacother. 1986;40(1):4–5. [PubMed] [Google Scholar]
  12. Snape W. J., Jr, Matarazzo S. A., Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology. 1978 Sep;75(3):373–378. [PubMed] [Google Scholar]
  13. Sullivan M. A., Cohen S., Snape W. J., Jr Colonic myoelectrical activity in irritable-bowel syndrome. Effect of eating and anticholinergics. N Engl J Med. 1978 Apr 20;298(16):878–883. doi: 10.1056/NEJM197804202981604. [DOI] [PubMed] [Google Scholar]
  14. Traube M., Lange R. C., McAllister R. G., Jr, McCallum R. W. Effect of nifedipine on gastric emptying in normal subjects. Dig Dis Sci. 1985 Aug;30(8):710–712. doi: 10.1007/BF01320483. [DOI] [PubMed] [Google Scholar]
  15. Whitehead W. E., Engel B. T., Schuster M. M. Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig Dis Sci. 1980 Jun;25(6):404–413. doi: 10.1007/BF01395503. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES