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. 1987 Dec;28(12):1613–1618. doi: 10.1136/gut.28.12.1613

Colonic myoelectrical activity in IBS painless diarrhoea.

J Frexinos 1, J Fioramonti 1, L Bueno 1
PMCID: PMC1433945  PMID: 3428689

Abstract

Colonic myoelectrical activity was recorded during 24 hours in 23 patients with painless diarrhoea and compared with a control group of 10 healthy subjects without digestive functional disorders. Diurnal fasting activity showed no significant difference in the total long spike bursts activity (LSB lasting greater than 7 seconds), but short spike bursts activity (SSB, lasting less than 7 seconds) was significantly lower (p less than 0.05) in diarrhoeal patients. A striking difference was observed in colonic response to eating, with an increased number of migrating long spike bursts (MLSB: mass movements) during the first postprandial hour in diarrhoeal patients (p less than 0.001), while short spike bursts (segmental activity) were almost absent in the rectosigmoid area. A marked decrease in the retrograde LSB activity was also observed in eight patients. During the night (from 2200 h to 0600 h) the number of migrating long spike bursts was increased in the diarrhoea group, but almost absent in controls (p less than 0.001). This study shows that colonic motor activity was altered in painless diarrhoea. These disturbances were not limited to the decreased SSB activity in the sigmoid, but involved the whole colon, with lower SSB activity and abnormal increase of migrating long spike bursts activity (MLSB) in postprandial and nocturnal periods.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bueno L., Fioramonti J., Ruckebusch Y., Frexinos J., Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders. Gut. 1980 Jun;21(6):480–485. doi: 10.1136/gut.21.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burns T. W. Colonic motility in the irritable bowel syndrome. Arch Intern Med. 1980 Feb;140(2):247–251. [PubMed] [Google Scholar]
  3. CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns of motility. Gastroenterology. 1961 Jan;40:1–17. [PubMed] [Google Scholar]
  4. CONNELL A. M. The motility of the pelvic colon. II. Paradoxical motility in diarrhoea and constipation. Gut. 1962 Dec;3:342–348. doi: 10.1136/gut.3.4.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cann P. A., Read N. W., Brown C., Hobson N., Holdsworth C. D. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut. 1983 May;24(5):405–411. doi: 10.1136/gut.24.5.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chauve A., Devroede G., Bastin E. Intraluminal pressures during perfusion of the human colon in situ. Gastroenterology. 1976 Mar;70(3):336–340. [PubMed] [Google Scholar]
  7. Chowdhury A. R., Dinoso V. P., Lorber S. H. Characterization of a hyperactive segment at the rectosigmoid junction. Gastroenterology. 1976 Oct;71(4):584–588. [PubMed] [Google Scholar]
  8. Fioramonti J., Droy-Lefaix M. T., Buéno L. Changes in gastro-intestinal motility induced by cholera toxin and experimental osmotic diarrhoea in dogs: effects of treatment with an argillaceous compound. Digestion. 1987;36(4):230–237. doi: 10.1159/000199423. [DOI] [PubMed] [Google Scholar]
  9. Fioramonti J., Garcia-Villar R., Bueno L., Ruckebusch Y. Colonic myoelectrical activity and propulsion in the dog. Dig Dis Sci. 1980 Sep;25(9):641–646. doi: 10.1007/BF01308321. [DOI] [PubMed] [Google Scholar]
  10. Frexinos J., Bueno L., Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985 May;88(5 Pt 1):1104–1110. doi: 10.1016/s0016-5085(85)80067-6. [DOI] [PubMed] [Google Scholar]
  11. Hachet T., Bueno L., Fioramonti J., Frexinos J. On-line four channel measurements of colonic myoelectrical activity in humans using a compact portable microcomputer (EPSON HX20). Int J Biomed Comput. 1985 Sep;17(2):115–121. doi: 10.1016/0020-7101(85)90082-0. [DOI] [PubMed] [Google Scholar]
  12. Hardcastle J. D., Mann C. V. Study of large bowel peristalsis. Gut. 1968 Oct;9(5):512–520. doi: 10.1136/gut.9.5.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hinton J. M., Lennard-Jones J. E., Young A. C. A ne method for studying gut transit times using radioopaque markers. Gut. 1969 Oct;10(10):842–847. doi: 10.1136/gut.10.10.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jian R., Najean Y., Bernier J. J. Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique. Gut. 1984 Jul;25(7):728–731. doi: 10.1136/gut.25.7.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kumar D., Wingate D. L. The irritable bowel syndrome: a paroxysmal motor disorder. Lancet. 1985 Nov 2;2(8462):973–977. doi: 10.1016/s0140-6736(85)90525-2. [DOI] [PubMed] [Google Scholar]
  16. Preston D. M., Adrian T. E., Christofides N. D., Lennard-Jones J. E., Bloom S. R. Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders. Gut. 1985 Oct;26(10):1059–1064. doi: 10.1136/gut.26.10.1059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Read N. W. Diarrhée motrice. Clin Gastroenterol. 1986 Jul;15(3):657–686. [PubMed] [Google Scholar]
  18. Read N. W., Miles C. A., Fisher D., Holgate A. M., Kime N. D., Mitchell M. A., Reeve A. M., Roche T. B., Walker M. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology. 1980 Dec;79(6):1276–1282. [PubMed] [Google Scholar]
  19. Sarna S. K., Waterfall W. E., Bardakjian B. L., Lind J. F. Types of human colonic electrical activities recorded postoperatively. Gastroenterology. 1981 Jul;81(1):61–70. [PubMed] [Google Scholar]
  20. Schang J. C., Devroede G. Fasting and postprandial myoelectric spiking activity in the human sigmoid colon. Gastroenterology. 1983 Nov;85(5):1048–1053. [PubMed] [Google Scholar]
  21. Waller S. L., Misiewicz J. J., Kiley N. Effect of eating on motility of the pelvic colon in constipation or diarrhoea. Gut. 1972 Oct;13(10):805–811. doi: 10.1136/gut.13.10.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Whitehead W. E., Engel B. T., Schuster M. M. Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig Dis Sci. 1980 Jun;25(6):404–413. doi: 10.1007/BF01395503. [DOI] [PubMed] [Google Scholar]
  23. Williams I. Mass movements (mass peristalsis) and diverticular disease OF THE COLON. Br J Radiol. 1967 Jan;40(469):2–14. doi: 10.1259/0007-1285-40-469-2. [DOI] [PubMed] [Google Scholar]

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