Abstract
Evidence of cytomegalovirus infection has been sought in a consecutive series of patients requiring colonic resection for idiopathic inflammatory bowel disease confined to the colon. Colonic tissue was examined by light and electron microscopy for cytomegalovirus inclusion bodies and cytomegalovirus antigen was sought using an immunoperoxidase technique. Cytomegalovirus infection was identified in three of 26 patients studied, but the infection did not appear to influence the course of the colitis. Although all three patients with cytomegalovirus infection needed urgent surgery, none had toxic megacolon. No evidence of cytomegalovirus infection was found in three other patients with toxic megacolon. One patient, who had a rising titre of IgG to cytomegalovirus received treatment with acyclovir which eradicated cytomegalovirus from the colon without altering the course of the colitis.
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- Cooper H. S., Raffensperger E. C., Jonas L., Fitts W. T., Jr Cytomegalovirus inclusions in patients with ulcerative colitis and toxic dilation requiring colonic resection. Gastroenterology. 1977 Jun;72(6):1253–1256. [PubMed] [Google Scholar]
- Farmer G. W., Vincent M. M., Fuccillo D. A., Horta-Barbosa L., Ritman S., Sever J. L., Gitnick G. L. Viral investigations in ulcerative colitis and regional enteritis. Gastroenterology. 1973 Jul;65(1):8–18. [PubMed] [Google Scholar]
- Foucar E., Mukai K., Foucar K., Sutherland D. E., Van Buren C. T. Colon ulceration in lethal cytomegalovirus infection. Am J Clin Pathol. 1981 Dec;76(6):788–801. doi: 10.1093/ajcp/76.6.788. [DOI] [PubMed] [Google Scholar]
- Goodman Z. D., Boitnott J. K., Yardley J. H. Perforation of the colon associated with cytomegalovirus infection. Dig Dis Sci. 1979 May;24(5):376–380. doi: 10.1007/BF01297124. [DOI] [PubMed] [Google Scholar]
- LEVINE R. S., WARNER N. E., JOHNSON C. F. CYTOMEGALIC INCLUSION DISEASE IN THE GASTRO-INTESTINAL TRACT OF ADULTS. Ann Surg. 1964 Jan;159:37–48. doi: 10.1097/00000658-196401000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MEDEARIS D. N., Jr Cytomegalic inclusion disease; an analysis of the clinical features based on the literature and six additional cases. Pediatrics. 1957 Mar;19(3):467–480. [PubMed] [Google Scholar]
- Meiselman M. S., Cello J. P., Margaretten W. Cytomegalovirus colitis. Report of the clinical, endoscopic, and pathologic findings in two patients with the acquired immune deficiency syndrome. Gastroenterology. 1985 Jan;88(1 Pt 1):171–175. doi: 10.1016/s0016-5085(85)80150-5. [DOI] [PubMed] [Google Scholar]
- Papadimitriou J. M., Shellam G. R., Robertson T. A. An ultrastructural investigation of cytomegalovirus replication in murine hepatocytes. J Gen Virol. 1984 Nov;65(Pt 11):1979–1990. doi: 10.1099/0022-1317-65-11-1979. [DOI] [PubMed] [Google Scholar]
- Price A. B., Morson B. C. Inflammatory bowel disease: the surgical pathology of Crohn's disease and ulcerative colitis. Hum Pathol. 1975 Jan;6(1):7–29. doi: 10.1016/s0046-8177(75)80107-9. [DOI] [PubMed] [Google Scholar]
- Sidi S., Graham J. H., Razvi S. A., Banks P. A. Cytomegalovirus infection of the colon associated with ulcerative colitis. Arch Surg. 1979 Jul;114(7):857–859. doi: 10.1001/archsurg.1979.01370310099019. [DOI] [PubMed] [Google Scholar]
- Swarbrick E. T., Kingham J. G., Price H. L., Blackshaw A. J., Griffiths P. D., Darougar S., Buckell N. A. Chlamydia, cytomegalovirus, and Yersinia in inflammatory bowel disease. Lancet. 1979 Jul 7;2(8132):11–12. doi: 10.1016/s0140-6736(79)90176-4. [DOI] [PubMed] [Google Scholar]
- Tamura H. Acute ulcerative colitis associated with cytomegalic inclusion virus. Arch Pathol. 1973 Sep;96(3):164–167. [PubMed] [Google Scholar]
- VOGEL F. S. Enhanced susceptibility of proliferating endothelium to salivary gland virus under naturally occurring and experimental conditions. Am J Pathol. 1958 Nov-Dec;34(6):1069–1079. [PMC free article] [PubMed] [Google Scholar]