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. 1988 Oct;29(10):1342–1348. doi: 10.1136/gut.29.10.1342

HLA-DR expression in human fetal intestinal epithelium.

T T MacDonald 1, A Weinel 1, J Spencer 1
PMCID: PMC1433992  PMID: 3143626

Abstract

Villus epithelial cells in fetal human small intestine are HLA-DR- until 17 weeks gestation. At 18 weeks HLA-DR begins to be expressed in the epithelial cells, usually at the villus tips. Of 13 specimens examined between 18 and 22 weeks gestation, two were HLD-DR-, seven had HLA-DR expressed only at the villus tips and in four most of the villus epithelial cells were HLA-DR+. The epithelium overlying the Peyer's patches in fetal intestine was also HLA-DR+. T cells in explant cultures of fetal intestine were activated in situ using pokeweed mitogen. The local cell mediated immune reaction increased expression of HLA-DR on the villus and crypt epithelial cells. Organ culture supernatants from explants treated with pokeweed mitogen induced HLA-DR expression on the HT-29 epithelial cell line; an effect inhibited by antibody against human interferon gamma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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