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. 1986 Nov;27(11):1373–1376. doi: 10.1136/gut.27.11.1373

Primary biliary cirrhosis in men.

M R Lucey, J M Neuberger, R Williams
PMCID: PMC1434080  PMID: 3792920

Abstract

To determine whether primary biliary cirrhosis differed in men and women we reviewed the presenting features and clinical course of 39 men and 191 women with primary biliary cirrhosis followed at this unit between 1970 and 1984. Age and severity of disease at time of diagnosis were similar in both groups. Pruritus was significantly less common in men than in women both at diagnosis and throughout the period of follow up (p less than 0.01). The difference in incidence of pruritus at diagnosis was most evident when the male group were compared with a group of premenopausal women, an observation which is consistent with involvement of sex steroid metabolism in the origin of pruritus. Skin pigmentation was also less marked in men at diagnosis (p less than 0.05). Autoimmune associated conditions, especially sicca syndrome, were more common in women. Survival was similar among men and women although hepatoma developed significantly more frequently in male patients (p less than 0.01).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christensen E., Crowe J., Doniach D., Popper H., Ranek L., Rodés J., Tygstrup N., Williams R. Clinical pattern and course of disease in primary biliary cirrhosis based on an analysis of 236 patients. Gastroenterology. 1980 Feb;78(2):236–246. [PubMed] [Google Scholar]
  2. Christensen E., Neuberger J., Crowe J., Altman D. G., Popper H., Portmann B., Doniach D., Ranek L., Tygstrup N., Williams R. Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis. Final results of an international trial. Gastroenterology. 1985 Nov;89(5):1084–1091. doi: 10.1016/0016-5085(85)90213-6. [DOI] [PubMed] [Google Scholar]
  3. Crowe J., Christensen E., Smith M., Cochrane M., Ranek L., Watkinson G., Doniach D., Popper H., Tygstrup N., Williams R. Azathioprine in primary biliary cirrhosis: a preliminary report of an international trial. Gastroenterology. 1980 May;78(5 Pt 1):1005–1010. [PubMed] [Google Scholar]
  4. James O., Macklon A. F., Watson A. J. Primary biliary cirrhosis--a revised clinical spectrum. Lancet. 1981 Jun 13;1(8233):1278–1281. doi: 10.1016/s0140-6736(81)92457-0. [DOI] [PubMed] [Google Scholar]
  5. Kaplowitz N., Finlayson N. D., Walmsley P., Thurnherr N., Javitt N. B. Hepatobiliary diseases associated with serum antimitochondrial antibody (AMA). Am J Med. 1973 Jun;54(6):725–730. doi: 10.1016/0002-9343(73)90058-2. [DOI] [PubMed] [Google Scholar]
  6. Krasner N., Johnson P. J., Portmann B., Watkinson G., Macsween R. N., Williams R. Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases. Gut. 1979 Mar;20(3):255–258. doi: 10.1136/gut.20.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Melia W. M., Johnson P. J., Neuberger J., Zaman S., Portmann B. C., Williams R. Hepatocellular carcinoma in primary biliary cirrhosis: detection by alpha-fetoprotein estimation. Gastroenterology. 1984 Sep;87(3):660–663. [PubMed] [Google Scholar]
  8. Neuberger J., Christensen E., Portmann B., Caballeria J., Rodes J., Ranek L., Tygstrup N., Williams R. Double blind controlled trial of d-penicillamine in patients with primary biliary cirrhosis. Gut. 1985 Feb;26(2):114–119. doi: 10.1136/gut.26.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. OSBORN E. C., WOOTTON I. D., da SILVA L., SHERLOCK S. Serum-bile-acid levels in liver disease. Lancet. 1959 Dec 12;2(7111):1049–1053. doi: 10.1016/s0140-6736(59)91527-2. [DOI] [PubMed] [Google Scholar]
  10. Pertsemlidis D., Panveliwalla D., Ahrens E. H., Jr Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology. 1974 Apr;66(4):565–573. [PubMed] [Google Scholar]
  11. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reynolds T. B. The "butterfly" sign in patients with chronic jaundice and pruritus. Ann Intern Med. 1973 Apr;78(4):545–546. doi: 10.7326/0003-4819-78-4-545. [DOI] [PubMed] [Google Scholar]
  13. Rubel L. R., Rabin L., Seeff L. B., Licht H., Cuccherini B. A. Does primary biliary cirrhosis in men differ from primary biliary cirrhosis in women? Hepatology. 1984 Jul-Aug;4(4):671–677. doi: 10.1002/hep.1840040418. [DOI] [PubMed] [Google Scholar]
  14. Sherlock S., Scheuer P. J. The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engl J Med. 1973 Sep 27;289(13):674–678. doi: 10.1056/NEJM197309272891306. [DOI] [PubMed] [Google Scholar]

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