Skip to main content
PMC home page
Gut logoLink to Gut
. 1989 Jun;30(6):811–814. doi: 10.1136/gut.30.6.811

Influence of orocaecal transit time on hydrogen excretion after carbohydrate malabsorption.

J J Rumessen 1, O Hamberg 1, E Gudmand-Høyer 1
PMCID: PMC1434140  PMID: 2753406

Abstract

The aim of the present study was to determine whether changes in orocaecal transit time (OCTT) affect the magnitude of the breath hydrogen (H2) excretion after ingestion of unabsorbable carbohydrate. We studied eight healthy subjects by interval sampling of end expiratory H2 concentration for 12 hours after ingestion of: (1) 10 g lactulose (L); (2) 10 g L with 20 mg metoclopramide (M) as tablets; (3) 20 g L, and (4) 20 g L with 7.5 mg diphenoxylate (D) as tablets, in random order. In spite of significant changes in OCTT after M and D, there were no significant changes, compared for the same dose of lactulose, with respect to area under the breath H2 excretion curves, peak increments of H2 concentration or timing of the peak increment. We conclude that, within the ranges observed, the OCTT does not significantly affect the shape of the H2 concentration versus time curves. In comparative studies estimates of the degree of carbohydrate malabsorption on the basis of breath H2 concentration may be valid in spite of differences in OCTT.

Full text

PDF
811

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson I. H., Levine A. S., Levitt M. D. Incomplete absorption of the carbohydrate in all-purpose wheat flour. N Engl J Med. 1981 Apr 9;304(15):891–892. doi: 10.1056/NEJM198104093041507. [DOI] [PubMed] [Google Scholar]
  2. Basilisco G., Bozzani A., Camboni G., Recchia M., Quatrini M., Conte D., Penagini R., Bianchi P. A. Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test. Gut. 1985 Jul;26(7):700–703. doi: 10.1136/gut.26.7.700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bond J. H., Jr, Levitt M. D., Prentiss R. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med. 1975 Apr;85(4):546–555. [PubMed] [Google Scholar]
  4. Bond J. H., Jr, Levitt M. D. Use of pulmonary hydrogen (H 2 ) measurements to quantitate carbohydrate absorption. Study of partially gastrectomized patients. J Clin Invest. 1972 May;51(5):1219–1225. doi: 10.1172/JCI106916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Florent C., Flourie B., Leblond A., Rautureau M., Bernier J. J., Rambaud J. C. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). J Clin Invest. 1985 Feb;75(2):608–613. doi: 10.1172/JCI111738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Flourié B., Florent C., Etanchaud F., Evard D., Franchisseur C., Rambaud J. C. Starch absorption by healthy man evaluated by lactulose hydrogen breath test. Am J Clin Nutr. 1988 Jan;47(1):61–66. doi: 10.1093/ajcn/47.1.61. [DOI] [PubMed] [Google Scholar]
  7. Harms H. K., Bertele-Harms R. M., Bruer-Kleis D. Enzyme-substitution therapy with the yeast Saccharomyces cerevisiae in congenital sucrase-isomaltase deficiency. N Engl J Med. 1987 May 21;316(21):1306–1309. doi: 10.1056/NEJM198705213162104. [DOI] [PubMed] [Google Scholar]
  8. Holgate A. M., Read N. W. Metoclopramide reduces carbohydrate absorption in man. Br J Clin Pharmacol. 1985 Jan;19(1):67–72. doi: 10.1111/j.1365-2125.1985.tb02614.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kolars J. C., Levitt M. D., Aouji M., Savaiano D. A. Yogurt--an autodigesting source of lactose. N Engl J Med. 1984 Jan 5;310(1):1–3. doi: 10.1056/NEJM198401053100101. [DOI] [PubMed] [Google Scholar]
  10. Levitt M. D., Hirsh P., Fetzer C. A., Sheahan M., Levine A. S. H2 excretion after ingestion of complex carbohydrates. Gastroenterology. 1987 Feb;92(2):383–389. doi: 10.1016/0016-5085(87)90132-6. [DOI] [PubMed] [Google Scholar]
  11. Mastropaolo G., Rees W. D. Evaluation of the hydrogen breath test in man: definition and elimination of the early hydrogen peak. Gut. 1987 Jun;28(6):721–725. doi: 10.1136/gut.28.6.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Metz G., Jenkins D. J., Peters T. J., Newman A., Blendis L. M. Breath hydrogen as a diagnostic method for hypolactasia. Lancet. 1975 May 24;1(7917):1155–1157. doi: 10.1016/s0140-6736(75)93135-9. [DOI] [PubMed] [Google Scholar]
  13. Nilsson F., Johansson H. A double isotope technique for the evaluation of drug action on gastric evacuation and small bowel propulsion studied in the rat. Gut. 1973 Jun;14(6):475–477. doi: 10.1136/gut.14.6.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. O'Brien J. D., Thompson D. G., McIntyre A., Burnham W. R., Walker E. Effect of codeine and loperamide on upper intestinal transit and absorption in normal subjects and patients with postvagotomy diarrhoea. Gut. 1988 Mar;29(3):312–318. doi: 10.1136/gut.29.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Perman J. A., Modler S., Olson A. C. Role of pH in production of hydrogen from carbohydrates by colonic bacterial flora. Studies in vivo and in vitro. J Clin Invest. 1981 Mar;67(3):643–650. doi: 10.1172/JCI110079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Phillips S. F., Quigley E. M., Kumar D., Kamath P. S. Motility of the ileocolonic junction. Gut. 1988 Mar;29(3):390–406. doi: 10.1136/gut.29.3.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Read N. W., Al-Janabi M. N., Bates T. E., Holgate A. M., Cann P. A., Kinsman R. I., McFarlane A., Brown C. Interpretation of the breath hydrogen profile obtained after ingesting a solid meal containing unabsorbable carbohydrate. Gut. 1985 Aug;26(8):834–842. doi: 10.1136/gut.26.8.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Read N. W., Miles C. A., Fisher D., Holgate A. M., Kime N. D., Mitchell M. A., Reeve A. M., Roche T. B., Walker M. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology. 1980 Dec;79(6):1276–1282. [PubMed] [Google Scholar]
  19. Rosado J. L., Deodhar A. D., Bourges H., Solomons N. W. The effect of the digestion products of lactose (glucose and galactose) on its intraintestinal, in vivo hydrolysis by exogenous microbial beta-D-galactosidase. J Am Coll Nutr. 1986;5(3):281–290. doi: 10.1080/07315724.1986.10720131. [DOI] [PubMed] [Google Scholar]
  20. Rumessen J. J., Gudmand-Høyer E. Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut. 1986 Oct;27(10):1161–1168. doi: 10.1136/gut.27.10.1161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rumessen J. J., Gudmand-Høyer E. Retention and variability of hydrogen (H2) samples stored in plastic syringes. Scand J Clin Lab Invest. 1987 Oct;47(6):627–629. doi: 10.1080/00365518709168479. [DOI] [PubMed] [Google Scholar]
  22. Rumessen J. J., Kokholm G., Gudmand-Høyer E. Methodological aspects of breath hydrogen (H2) analysis. Evaluation of a H2 monitor and interpretation of the breath H2 test. Scand J Clin Lab Invest. 1987 Oct;47(6):555–560. doi: 10.1080/00365518709168468. [DOI] [PubMed] [Google Scholar]
  23. Schulze-Delrieu K. Metoclopramide. Gastroenterology. 1979 Oct;77(4 Pt 1):768–779. [PubMed] [Google Scholar]
  24. Thompson D. G., O'Brien J. D., Hardie J. M. Influence of the oropharyngeal microflora on the measurement of exhaled breath hydrogen. Gastroenterology. 1986 Oct;91(4):853–860. doi: 10.1016/0016-5085(86)90686-4. [DOI] [PubMed] [Google Scholar]
  25. Thornton J. R., Dryden A., Kelleher J., Losowsky M. S. Does super efficient starch absorption promote diverticular disease? Br Med J (Clin Res Ed) 1986 Jun 28;292(6537):1708–1710. doi: 10.1136/bmj.292.6537.1708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Van Wyk M., Sommers D. K., Steyn A. G. Evaluation of gastrointestinal motility using the hydrogen breath test. Br J Clin Pharmacol. 1985 Nov;20(5):479–481. doi: 10.1111/j.1365-2125.1985.tb05101.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES