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. 1989 May;30(5):671–674. doi: 10.1136/gut.30.5.671

Significance of prostaglandin E2 in acute necrotising pancreatitis in rats.

B van Ooijen 1, W J Kort 1, C J Tinga 1, J H Wilson 1, D L Westbroek 1
PMCID: PMC1434199  PMID: 2731761

Abstract

Acute necrotising pancreatitis in rats was induced by injecting 5% sodium taurocholate into the pancreatic duct. Prostaglandin E2 (100 micrograms/kg subcutaneously twice) decreased the mortality rate from 100% to 60% (NS). When treatment with prostaglandin E2 was combined with simultaneous administration of either dazmegrel (UK 38,485, 50 mg/kg bodyweight) or Sibelium (Flunarizine R 14,950, 0.2 mg/kg body weight) a significant decrease in the mortality rate (p less than 0.05) was recorded. Dazmegrel is a selective thromboxane A2 synthetase inhibitor and prevents the formation of thromboxane A2. Flunarizine (a calcium entry blocker) decreases thromboxane A2 formation and also inhibits the effects of raised thromboxane A2 concentrations. As plasma thromboxane B2 (the stable metabolite of thromboxane A2) concentrations increase and the plasma prostaglandin E2 concentrations decrease in acute necrotising pancreatitis in rats, the results of the present study indicate that these prostaglandins play a role in the pathophysiology of the disease. It is suggested that restoration of the balance in prostanoid concentrations will have a beneficial effect on the course of acute necrotising pancreatitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coelle E. F., Adham N., Elashoff J., Lewin K., Taylor I. L. Effects of prostaglandin and indomethacin on diet-induced acute pancreatitis in mice. Gastroenterology. 1983 Dec;85(6):1307–1312. [PubMed] [Google Scholar]
  2. Crocket K. V., Brackett K., Crocket A., Jacobson E. D., Rao S. S., Joffe S. N. Prostaglandin E1 treatment in experimental acute pancreatitis in the rat. Eur Surg Res. 1984;16(5):265–273. doi: 10.1159/000128418. [DOI] [PubMed] [Google Scholar]
  3. Dawiskiba J., Isaksson B., Jeppsson B., Hägerstrand I., Bengmark S. Cytoprotective effect of 16,16-dimethyl prostaglandin (PGE2) on ischemic splanchnic injuries in the rat. Eur Surg Res. 1984;16(2):77–83. doi: 10.1159/000128391. [DOI] [PubMed] [Google Scholar]
  4. De Clerck F., Van Nueten J. M. Platelet-mediated vascular contractions. Inhibition by flunarizine, a calcium-entry blocker. Biochem Pharmacol. 1983 Mar 1;32(5):765–771. doi: 10.1016/0006-2952(83)90574-9. [DOI] [PubMed] [Google Scholar]
  5. Fischer S., Struppler M., Böhlig B., Bernutz C., Wober W., Weber P. C. The influence of selective thromboxane synthetase inhibition with a novel imidazole derivative, UK-38,485, on prostanoid formation in man. Circulation. 1983 Oct;68(4):821–826. doi: 10.1161/01.cir.68.4.821. [DOI] [PubMed] [Google Scholar]
  6. Lankisch P. G., Göke B., Kunze H., Otto J., Winckler K. Does PGE2 have a beneficial effect on acute experimental pancreatitis in the rat? Hepatogastroenterology. 1983 Aug;30(4):148–150. [PubMed] [Google Scholar]
  7. Manabe T., Steer M. L. Protective effects of PGE2 on diet-induced acute pancreatitis in mice. Gastroenterology. 1980 Apr;78(4):777–781. [PubMed] [Google Scholar]
  8. Robert A. Prostaglandins and digestive diseases. Adv Prostaglandin Thromboxane Res. 1980;8:1533–1541. [PubMed] [Google Scholar]
  9. Standfield N. J., Kakkar V. V. Prostaglandins and acute pancreatitis--experimental and clinical studies. Br J Surg. 1983 Oct;70(10):573–576. doi: 10.1002/bjs.1800701002. [DOI] [PubMed] [Google Scholar]
  10. Warshaw A. L., O'Hara P. J. Susceptibility of the pancreas to ischemic injury in shock. Ann Surg. 1978 Aug;188(2):197–201. doi: 10.1097/00000658-197808000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wedgwood K. R., Farmer R. C., Reber H. A. A model of hemorrhagic pancreatitis in cats--role of 16,16-dimethyl prostaglandin E2. Gastroenterology. 1986 Jan;90(1):32–39. doi: 10.1016/0016-5085(86)90071-5. [DOI] [PubMed] [Google Scholar]
  12. van Ooijen B., Ouwendijk R. J., Kort W. J., Zijlstra F. J., Vincent J. E., Wilson J. H., Westbroek D. L. Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin. Scand J Gastroenterol. 1988 Mar;23(2):188–192. doi: 10.3109/00365528809103966. [DOI] [PubMed] [Google Scholar]

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