Abstract
Standard oesophageal scintigraphic techniques using 99mTc-colloids rarely identify oesophageal mucosal damage. Sucralfate can be labelled with 99mTc for the detection of oesophageal mucosal ulceration. This method uses two separate supine swallows of 10 MBq 99mTc-colloid in 10 ml, followed by a single supine swallow of 30 MBq 99mTc-sucralfate. The data are processed to give time-activity curves, mean transit times and condensed dynamic images. When oesophageal ulceration is detected, the time-activity curves using sucralfate show residual activity in the oesophagus after the transit time indicated by the colloid swallow. The condensed dynamic image shows a persistence of activity at the level of the ulceration. Erect sucralfate images taken immediately after the dynamic sequence show no oesophageal localisation. The results from a study of 62 patients have shown excellent correlation between the dynamic 99mTc-sucralfate images and endoscopy findings. Sequential sucralfate studies for healing also correlate well. The use of labelled sucralfate to detect oesophageal ulceration could modify the indications for endoscopy in gastrooesophageal reflux disease.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dawson D. J., Khan A. N., Miller V., Ratcliffe J. F., Shreeve D. R. Detection of inflammatory bowel disease in adults and children: evaluation of a new isotopic technique. Br Med J (Clin Res Ed) 1985 Nov 2;291(6504):1227–1230. doi: 10.1136/bmj.291.6504.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dawson D. J., Khan A. N., Nuttall P., Shreeve D. R. Technetium 99m-labelled-sucralphate isotope scanning in the detection of peptic ulceration. Nucl Med Commun. 1985 Jun;6(6):319–325. doi: 10.1097/00006231-198506000-00003. [DOI] [PubMed] [Google Scholar]
- De Vincentis N., Lenti R., Pona C., Lococo A., Crisci R., Coloni G. F., Flütsch I. C., Mariani G. Scintigraphic evaluation of the esophageal transit time for the noninvasive assessment of esophageal motor disorders. J Nucl Med Allied Sci. 1984 Jul-Sep;28(3):137–142. [PubMed] [Google Scholar]
- Goff J. S., Adcock K. A., Schmelter R. Detection of esophageal ulcerations with technetium-99m albumin sucralfate. J Nucl Med. 1986 Jul;27(7):1143–1146. [PubMed] [Google Scholar]
- Ham H. R., Georges B., Guillaume M., Erbsmann F., Dobbeleir A. Evaluation of methods for qualitative and quantitative assessment of esophageal transit of liquid. Eur J Nucl Med. 1985;11(1):17–21. doi: 10.1007/BF00440955. [DOI] [PubMed] [Google Scholar]
- Nagashima R. Development and characteristics of sucralfate. J Clin Gastroenterol. 1981;3(Suppl 2):103–110. [PubMed] [Google Scholar]
- Nagashima R. Mechanisms of action of sucralfate. J Clin Gastroenterol. 1981;3(Suppl 2):117–127. [PubMed] [Google Scholar]
- Samloff I. M. Inhibition of peptic aggression by sucralfate. The view from the ulcer crater. Scand J Gastroenterol Suppl. 1983;83:7–11. [PubMed] [Google Scholar]
- Vasquez T. E., Bridges R. L., Braunstein P., Jansholt A. L., Meshkinpour H. Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent. Radiology. 1983 Jul;148(1):227–231. doi: 10.1148/radiology.148.1.6856841. [DOI] [PubMed] [Google Scholar]