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. 1989 Sep;30(9):1275–1278. doi: 10.1136/gut.30.9.1275

Increased oxidoreduction of deoxycholic acid in cholecystectomised patients.

K Einarsson 1, K Nilsell 1, I Björkhem 1
PMCID: PMC1434232  PMID: 2806996

Abstract

The extent of oxidoreduction of deoxycholic acid in the enterohepatic circulation was studied in seven healthy subjects and seven patients after cholecystectomy. (12 beta-3H) Deoxycholic acid was given orally together with (24-14C) labelled bile acid. The rate of oxidoreduction of the 12 alpha-hydroxyl group of deoxycholic acid was calculated from the decay in ratio between 3H and 14C. In spite of a normal proportion of deoxycholic acid and other secondary bile acids in bile, patients after cholecystectomy had more than two-fold higher degree of oxidoreduction of the 12 alpha-hydroxyl group than healthy controls. The high extent of oxidoreduction is probably because of an increased exposure of the bile acid pool to intestinal bacteria and may have physiological implications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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