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. 1989 Nov;30(11):1630–1640. doi: 10.1136/gut.30.11.1630

Growth and transformation of the small intestinal mucosa--importance of connective tissue, gut associated lymphoid tissue and gastrointestinal regulatory peptides.

E O Riecken 1, A Stallmach 1, M Zeitz 1, J D Schulzke 1, H Menge 1, M Gregor 1
PMCID: PMC1434331  PMID: 2689302

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asp N. G., Gudmand-Høyer E., Andersen B., Berg N. O. Enzyme activities and morphological appearance in functioning and excluded segments of the small intestine after shunt operation for obesity. Gut. 1979 Jul;20(7):553–558. doi: 10.1136/gut.20.7.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOOTH C. C. The metabolic effects of intestinal resection in man. Postgrad Med J. 1961 Dec;37:725–739. doi: 10.1136/pgmj.37.434.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bell G. I., Santerre R. F., Mullenbach G. T. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature. 1983 Apr 21;302(5910):716–718. doi: 10.1038/302716a0. [DOI] [PubMed] [Google Scholar]
  4. Bloch R., Menge H., Lingelbach B., Lorenz-Meyer H., Haberich F. J., Riecken E. O. The relationship between structure and function of small intestine in patients with a sprue syndrome and in healthy controls. Klin Wochenschr. 1973 Dec 1;51(23):1151–1158. doi: 10.1007/BF01468564. [DOI] [PubMed] [Google Scholar]
  5. Chaves M., Smith M. W., Williamson R. C. Increased activity of digestive enzymes in ileal enterocytes adapting to proximal small bowel resection. Gut. 1987 Aug;28(8):981–987. doi: 10.1136/gut.28.8.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Correa P., Cuello C., Duque E. Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J Natl Cancer Inst. 1970 Feb;44(2):297–306. [PubMed] [Google Scholar]
  7. Crean G. P., Marshall M. W., Rumsey R. D. Parietal cell hyperplasia induced by the administration of pentagastrin (ICI 50,123) to rats. Gastroenterology. 1969 Aug;57(2):147–155. [PubMed] [Google Scholar]
  8. DeClerck Y., Draper V., Parkman R. Clonal analysis of murine graft-vs-host disease. II. Leukokines that stimulate fibroblast proliferation and collagen synthesis in graft-vs. host disease. J Immunol. 1986 May 15;136(10):3549–3552. [PubMed] [Google Scholar]
  9. Ecknauer R., Rommel K. Zytostatika und Dünndarm. Klin Wochenschr. 1978 Jun 15;56(12):579–592. doi: 10.1007/BF01477006. [DOI] [PubMed] [Google Scholar]
  10. Elson C. O., Reilly R. W., Rosenberg I. H. Small intestinal injury in the graft versus host reaction: an innocent bystander phenomenon. Gastroenterology. 1977 May;72(5 Pt 1):886–889. [PubMed] [Google Scholar]
  11. Falchuk Z. M., Gebhard R. L., Sessoms C., Strober W. An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture. J Clin Invest. 1974 Feb;53(2):487–500. doi: 10.1172/JCI107582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Feldman E. J., Dowling R. H., McNaughton J., Peters T. J. Effects of oral versus intravenous nutrition on intestinal adaptation after small bowel resection in the dog. Gastroenterology. 1976 May;70(5 PT1):712–719. [PubMed] [Google Scholar]
  13. Friedman H. I., Villar H. V., Nemeth T. J. The mucosal response in the excluded limb after jejunoileal bypass for morbid obesity. Surg Gynecol Obstet. 1981 Sep;153(3):346–350. [PubMed] [Google Scholar]
  14. Gleeson M. H., Bloom S. R., Polak J. M., Henry K., Dowling R. H. Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut. 1971 Oct;12(10):773–782. doi: 10.1136/gut.12.10.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Goodlad R. A., Wilson T. J., Lenton W., Gregory H., McCullagh K. G., Wright N. A. Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats. Gut. 1987 May;28(5):573–582. doi: 10.1136/gut.28.5.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gregor M., Menge H., Stössel R., Riecken E. O. Effect of monoclonal antibodies to enteroglucagon on ileal adaptation after proximal small bowel resection. Gut. 1987;28 (Suppl):9–14. doi: 10.1136/gut.28.suppl.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Gregor M., Riecken E. O. Production and characterization of N-terminally and C-terminally directed monoclonal antibodies against pancreatic glucagon. Gastroenterology. 1985 Sep;89(3):571–580. doi: 10.1016/0016-5085(85)90453-6. [DOI] [PubMed] [Google Scholar]
  18. Gutschmidt S., Kaul W., Menge H., Riecken E. O. The adaptive response of disaccharidase activities at different sites along the villus epithelium after proximal intestinal resection in the rat. A microdensitometric study of enzyme kinetics. Res Exp Med (Berl) 1983;182(3):203–213. doi: 10.1007/BF01851709. [DOI] [PubMed] [Google Scholar]
  19. Górnacz G. E., Al-Mukhtar M. Y., Ghatei M. A., Sagor G. R., Wright N. A., Bloom S. R. Pattern of cell proliferation and enteroglucagon response following small bowel resection in the rat. Digestion. 1984;29(2):65–72. doi: 10.1159/000199012. [DOI] [PubMed] [Google Scholar]
  20. Haffen K., Kedinger M., Simon-Assmann P. M., Lacroix B. Mesenchyme-dependent differentiation of intestinal brush-border enzymes in the gizzard endoderm of the chick embryo. Prog Clin Biol Res. 1982;85(Pt B):261–270. [PubMed] [Google Scholar]
  21. Haffen K., Lacroix B., Kedinger M., Simon-Assmann P. M. Inductive properties of fibroblastic cell cultures derived from rat intestinal mucosa on epithelial differentiation. Differentiation. 1983;23(3):226–233. doi: 10.1111/j.1432-0436.1982.tb01287.x. [DOI] [PubMed] [Google Scholar]
  22. Hahn U., Schuppan D., Hahn E. G., Merker H. J., Riecken E. O. Intestinal cells produce basement membrane proteins in vitro. Gut. 1987;28 (Suppl):143–151. doi: 10.1136/gut.28.suppl.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Heinrich G., Gros P., Habener J. F. Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem. 1984 Nov 25;259(22):14082–14087. [PubMed] [Google Scholar]
  24. Holst J. J. Gut glucagon, enteroglucagon, gut glucagonlike immunoreactivity, glicentin--current status. Gastroenterology. 1983 Jun;84(6):1602–1613. [PubMed] [Google Scholar]
  25. Ishizuya-Oka A., Mizuno T. Intestinal cytodifferentiation in vitro of chick stomach endoderm induced by the duodenal mesenchyme. J Embryol Exp Morphol. 1984 Aug;82:163–176. [PubMed] [Google Scholar]
  26. James S. P., Graeff A. S., Zeitz M. Predominance of helper-inducer T cells in mesenteric lymph nodes and intestinal lamina propria of normal nonhuman primates. Cell Immunol. 1987 Jul;107(2):372–383. doi: 10.1016/0008-8749(87)90245-0. [DOI] [PubMed] [Google Scholar]
  27. Johnson L. R., Lichtenberger L. M., Copeland E. M., Dudrick S. J., Castro G. A. Action of gastrin on gastrointestinal structure and function. Gastroenterology. 1975 May;68(5 Pt 1):1184–1192. [PubMed] [Google Scholar]
  28. Johnson L. R. The trophic action of gastrointestinal hormones. Gastroenterology. 1976 Feb;70(2):278–288. [PubMed] [Google Scholar]
  29. Kedinger M., Simon-Assmann P. M., Lacroix B., Marxer A., Hauri H. P., Haffen K. Fetal gut mesenchyme induces differentiation of cultured intestinal endodermal and crypt cells. Dev Biol. 1986 Feb;113(2):474–483. doi: 10.1016/0012-1606(86)90183-1. [DOI] [PubMed] [Google Scholar]
  30. Lehy T., Accary J. P., Dubrasquet M., Lewin M. J. Growth hormone-releasing factor (somatocrinin) stimulates epithelial cell proliferation in the rat digestive tract. Gastroenterology. 1986 Mar;90(3):646–653. doi: 10.1016/0016-5085(86)91119-4. [DOI] [PubMed] [Google Scholar]
  31. Lehy T., Accary J. P., Labeille D., Dubrasquet M. Chronic administration of bombesin stimulates antral gastrin cell proliferation in the rat. Gastroenterology. 1983 May;84(5 Pt 1):914–919. [PubMed] [Google Scholar]
  32. Lehy T., Dubrasquet M., Bonfils S. Effect of somatostatin on normal and gastric-stimulated cell proliferation in the gastric and intestinal mucosae of the rat. Digestion. 1979;19(2):99–109. doi: 10.1159/000198330. [DOI] [PubMed] [Google Scholar]
  33. Lehy T., Puccio F., Chariot J., Labeille D. Stimulating effect of bombesin on the growth of gastrointestinal tract and pancreas in suckling rats. Gastroenterology. 1986 Jun;90(6):1942–1949. doi: 10.1016/0016-5085(86)90265-9. [DOI] [PubMed] [Google Scholar]
  34. MacDonald T. T., Ferguson A. Hypersensitivity reactions in the small intestine. 2. Effects of allograft rejection on mucosal architecture and lymphoid cell infiltrate. Gut. 1976 Feb;17(2):81–91. doi: 10.1136/gut.17.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. MacDonald T. T., Ferguson A. Hypersensitivity reactions in the small intestine. III. The effects of allograft rejection and of graft-versus-host disease on epithelial cell kinetics. Cell Tissue Kinet. 1977 Jul;10(4):301–312. [PubMed] [Google Scholar]
  36. MacDonald T. T., Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med. 1988 Apr 1;167(4):1341–1349. doi: 10.1084/jem.167.4.1341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Madara J. L., Trier J. S. Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest. 1980 Sep;43(3):254–261. [PubMed] [Google Scholar]
  38. Mak K. M., Chang W. W. Pentagastrin stimulates epithelial cell proliferation in duodenal and colonic crypts in fasted rats. Gastroenterology. 1976 Dec;71(6):1117–1120. [PubMed] [Google Scholar]
  39. Mathan M., Hermos J. A., Trier J. S. Structural features of the epithelio-mesenchymal interface of rat duodenal mucosa during development. J Cell Biol. 1972 Mar;52(3):577–588. doi: 10.1083/jcb.52.3.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Mayston P. D., Barrowman J. A., Dowling R. H. Effect of pentagastrin on small bowel structure and function in the rat. Digestion. 1975;12(2):78–84. doi: 10.1159/000197657. [DOI] [PubMed] [Google Scholar]
  41. Menge H., Bloch R., Schaumlöffel E., Riecken E. O. Transportstudien, morphologische, morphometrische und histochemische Untersuchungen zum Verhalten der Dünndarmschleimhaut im operativ ausgeschalteten Jejunalabschnitt der Ratte. Z Gesamte Exp Med. 1970;153(1):74–90. [PubMed] [Google Scholar]
  42. Menge H., Hopert R., Alexopoulos T., Riecken E. O. Three-dimensional structure and cell kinetics at different sites of rat intestinal remnants during the early adaptive response to resection. Res Exp Med (Berl) 1982;181(2):77–94. doi: 10.1007/BF01852185. [DOI] [PubMed] [Google Scholar]
  43. Menge H., Köhn R., Dietermann K. H., Lorenz-Meyer H., Riecken E. O., Robinson J. W. Structural and functional alterations in the mucosa of self-filling intestinal blind loops in rats. Clin Sci (Lond) 1979 Feb;56(2):121–131. doi: 10.1042/cs0560121. [DOI] [PubMed] [Google Scholar]
  44. Menge H., Murer H., Robinson J. W. Glucose transport by brush-border membrane vesicles after proximal resection or ileo-jejunal transposition in the rat. J Physiol. 1978 Jan;274:9–16. doi: 10.1113/jphysiol.1978.sp012130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Menge H., Robinson J. W. The relationship between the functional and structural alterations in the rat small intestine following proximal resection of varying extents. Res Exp Med (Berl) 1978 Jul 24;173(1):41–53. doi: 10.1007/BF01851373. [DOI] [PubMed] [Google Scholar]
  46. Menge H., Sepúlveda F. V., Smith M. W. Cellular adaptation of amino acid transport following intestinal resection in the rat. J Physiol. 1983 Jan;334:213–223. doi: 10.1113/jphysiol.1983.sp014490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Menge H., Stange G., Murer H. Funktionelle Charakterisierung luminaler Enterozytenmembranen atrophischer Dünndarmschleimhaut mittels isolierter Bürstensaum-Membranen. Z Gastroenterol. 1986 Nov;24(11):681–686. [PubMed] [Google Scholar]
  48. Morin C. L., Ling V. Effect of pentagastrin on the rat small intestine after resection. Gastroenterology. 1978 Aug;75(2):224–229. [PubMed] [Google Scholar]
  49. Mowat A. M., Ferguson A. Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse. Transplantation. 1981 Sep;32(3):238–243. doi: 10.1097/00007890-198109000-00011. [DOI] [PubMed] [Google Scholar]
  50. Neal J. V., Potten C. S. A critical assessment of the intestinal proliferon hypothesis. J Theor Biol. 1981 Jul 7;91(1):63–70. doi: 10.1016/0022-5193(81)90374-x. [DOI] [PubMed] [Google Scholar]
  51. Ponder B. A., Schmidt G. H., Wilkinson M. M., Wood M. J., Monk M., Reid A. Derivation of mouse intestinal crypts from single progenitor cells. Nature. 1985 Feb 21;313(6004):689–691. doi: 10.1038/313689a0. [DOI] [PubMed] [Google Scholar]
  52. Riecken E. O., Bloch R., Menge H., Idelberger K., Kramer F., Miller B., Lorenz-Meyer H. Morphologische und funktionelle Befunde nach Milchsäuredauerinfusion in das Jejunum der Ratte. Z Zellforsch Mikrosk Anat. 1972;132(1):107–129. [PubMed] [Google Scholar]
  53. Riecken E. O., Gregor M. Glucagon and small-bowel mucosa. Scand J Gastroenterol Suppl. 1985;112:30–40. doi: 10.3109/00365528509092210. [DOI] [PubMed] [Google Scholar]
  54. Riecken E. O., Sahlfeld M., Lorenz-Meyer H. Quantitative Untersuchungen zur dreidimensionalen Struktur der Dünndarmschleimhaut bei Besunden und Patienten mit einheimischer Sprue. Dtsch Med Wochenschr. 1976 Jan 9;101(2):51–53. [PubMed] [Google Scholar]
  55. Sagor G. R., Ghatei M. A., Al-Mukhtar M. Y., Wright N. A., Bloom S. R. Evidence for a humoral mechanism after small intestinal resection. Exclusion of gastrin but not enteroglucagon. Gastroenterology. 1983 May;84(5 Pt 1):902–906. [PubMed] [Google Scholar]
  56. Sagor G. R., Ghatei M. A., O'Shaughnessy D. J., Al-Mukhtar M. Y., Wright N. A., Bloom S. R. Influence of somatostatin and bombesin on plasma enteroglucagon and cell proliferation after intestinal resection in the rat. Gut. 1985 Jan;26(1):89–94. doi: 10.1136/gut.26.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Schulzke J. D., Fromm M., Bentzel C. J., Menge H., Riecken E. O. Adaptation of the jejunal mucosa in the experimental blind loop syndrome: changes in paracellular conductance and tight junction structure. Gut. 1987;28 (Suppl):159–164. doi: 10.1136/gut.28.suppl.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Simon-Assmann P., Kedinger M., Haffen K. Immunocytochemical localization of extracellular-matrix proteins in relation to rat intestinal morphogenesis. Differentiation. 1986;32(1):59–66. doi: 10.1111/j.1432-0436.1986.tb00556.x. [DOI] [PubMed] [Google Scholar]
  59. Spencer J., Cerf-Bensussan N., Jarry A., Brousse N., Guy-Grand D., Krajewski A. S., Isaacson P. G. Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. Am J Pathol. 1988 Jul;132(1):1–5. [PMC free article] [PubMed] [Google Scholar]
  60. Strober W., Falchuk Z. M., Rogentine G. N., Nelson D. L., Klaeveman H. L. The pathogenesis of gluten-sensitive enteropathy. Ann Intern Med. 1975 Aug;83(2):242–256. doi: 10.7326/0003-4819-83-2-242. [DOI] [PubMed] [Google Scholar]
  61. Svanes K., Ito S., Takeuchi K., Silen W. Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Morphologic and physiologic characteristics. Gastroenterology. 1982 Jun;82(6):1409–1426. [PubMed] [Google Scholar]
  62. Weser E., Hernandez M. H. Studies of small bowel adaptation after intestinal resection in the rat. Gastroenterology. 1971 Jan;60(1):69–75. [PubMed] [Google Scholar]
  63. Williamson R. C., Buchholtz T. W., Malt R. A. Humoral stimulation of cell proliferation in small bowel after transection and resection in rats. Gastroenterology. 1978 Aug;75(2):249–254. [PubMed] [Google Scholar]
  64. Williamson R. C. Intestinal adaptation (second of two parts). Mechanisms of control. N Engl J Med. 1978 Jun 29;298(26):1444–1450. doi: 10.1056/NEJM197806292982604. [DOI] [PubMed] [Google Scholar]
  65. Wright N., Watson A., Morley A., Appleton D., Marks J. Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut. 1973 Sep;14(9):701–710. doi: 10.1136/gut.14.9.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Zeitz M., Greene W. C., Peffer N. J., James S. P. Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation. Gastroenterology. 1988 Mar;94(3):647–655. doi: 10.1016/0016-5085(88)90235-1. [DOI] [PubMed] [Google Scholar]
  67. Zeitz M., Menge H., Riecken E. O. Early ultrastructural adaptive changes of ileal enterocytes after proximal small bowel resection as determined morphometrically. Res Exp Med (Berl) 1985;185(4):259–268. doi: 10.1007/BF01851950. [DOI] [PubMed] [Google Scholar]
  68. Zeitz M., Quinn T. C., Graeff A. S., James S. P. Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates. Gastroenterology. 1988 Feb;94(2):353–366. doi: 10.1016/0016-5085(88)90422-2. [DOI] [PubMed] [Google Scholar]

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