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. 1989 Nov;30(11):1530–1539. doi: 10.1136/gut.30.11.1530

Perturbation of upper gastrointestinal transit and antroduodenal motility by experimentally applied stress: the role of beta-adrenoreceptor mediated pathways.

J D O'Brien 1, D G Thompson 1, S J Day 1, W R Burnham 1, E Walker 1
PMCID: PMC1434332  PMID: 2557268

Abstract

A series of three experiments were performed on healthy adult volunteers to investigate the possible role played by beta-adrenoreceptor mediated pathways in the disturbance of human upper intestinal motor function by hand immersion in cold water. In the first experiment, (an extended pilot study on one individual), orocaecal transit of a standard meal was measured on 36 occasions with and without cold water stimulation and with and without a series of alpha and beta blocking drugs. Cold water stimulation consistently delayed transit in this individual, an effect which was attenuated by prior beta-blockade. In a double blind trial of the effect of beta-blocker atenolol v placebo on transit in nine individuals, a consistent reduction in the cold water induced transit delay was observed (p less than 0.01) independent of any direct effect of beta-blockade. In the third experiment seven individuals underwent repeated studies of antroduodenal pressure activity comparing the effects of cold and warm water stimulation with and without beta blockade to determine whether the observed transit effect could be related to an action on gastrointestinal motility. Cold water stimulation reduced antroduodenal motility, but no consistent effects of previous beta blockade were noted. These studies indicate the presence of a beta-adrenoreceptor mediated pathway in the cold water induced delay of orocaecal transit but not in the inhibition of gastroduodenal motility. Further studies are indicated to determine the site and mode of action of this transit effect more precisely.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ariëns E. J., Simonis A. M. Physiological and pharmacological aspects of adrenergic receptor classification. Biochem Pharmacol. 1983 May 15;32(10):1539–1545. doi: 10.1016/0006-2952(83)90324-6. [DOI] [PubMed] [Google Scholar]
  2. Azpiroz F., Malagelada J. R. Gastric tone measured by an electronic barostat in health and postsurgical gastroparesis. Gastroenterology. 1987 Apr;92(4):934–943. doi: 10.1016/0016-5085(87)90967-x. [DOI] [PubMed] [Google Scholar]
  3. Barrett A. M. The pharmacology of atenolol. Postgrad Med J. 1977;53 (Suppl 3):58–64. [PubMed] [Google Scholar]
  4. Bond J. H., Jr, Levitt M. D., Prentiss R. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med. 1975 Apr;85(4):546–555. [PubMed] [Google Scholar]
  5. Broadley K. J., Chess-Williams R. G., Grassby P. F. A physiological basis for subclassifying beta-adrenoceptors examined by chemical sympathectomy of guinea-pigs. J Physiol. 1986 Apr;373:367–378. doi: 10.1113/jphysiol.1986.sp016053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brown H. C., Carruthers S. G., Johnston G. D., Kelly J. G., McAinsh J., McDevitt D. G., Shanks R. G. Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker. Clin Pharmacol Ther. 1976 Nov;20(5):524–534. doi: 10.1002/cpt1976205524. [DOI] [PubMed] [Google Scholar]
  7. Cann P. A., Read N. W., Cammack J., Childs H., Holden S., Kashman R., Longmore J., Nix S., Simms N., Swallow K. Psychological stress and the passage of a standard meal through the stomach and small intestine in man. Gut. 1983 Mar;24(3):236–240. doi: 10.1136/gut.24.3.236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gillespie J. S., Khoyi M. A. The site and receptors responsible for the inhibition by sympathetic nerves of intestinal smooth muscle and its parasympathetic motor nerves. J Physiol. 1977 Jun;267(3):767–789. doi: 10.1113/jphysiol.1977.sp011837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kelly G. A., Rose R. C., Nahrwold D. L. Characteristics of inhibition of pancreatic secretion by isoproterenol. Surgery. 1977 Nov;82(5):680–684. [PubMed] [Google Scholar]
  10. Llewellyn-Smith I. J., Furness J. B., O'Brien P. E., Costa M. Noradrenergic nerves in human small intestine. Distribution and ultrastructure. Gastroenterology. 1984 Sep;87(3):513–529. [PubMed] [Google Scholar]
  11. Mason W. D., Winer N., Kochak G., Cohen I., Bell R. Kinetics and absolute bioavailability of atenolol. Clin Pharmacol Ther. 1979 Apr;25(4):408–415. doi: 10.1002/cpt1979254408. [DOI] [PubMed] [Google Scholar]
  12. Morris A. I., Turnberg L. A. Influence of isoproterenol and propranolol on human intestinal transport in vivo. Gastroenterology. 1981 Dec;81(6):1076–1079. [PubMed] [Google Scholar]
  13. O'Brien J. D., Thompson D. G., Burnham W. R., Holly J., Walker E. Action of centrally mediated autonomic stimulation on human upper gastrointestinal transit: a comparative study of two stimuli. Gut. 1987 Aug;28(8):960–969. doi: 10.1136/gut.28.8.960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Read N. W., Al Janabi M. N., Bates T. E., Barber D. C. Effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humans. Gastroenterology. 1983 Jun;84(6):1568–1572. [PubMed] [Google Scholar]
  15. Rees M. R., Clark R. A., Holdsworth C. D., Barber D. C., Howlett P. J. The effect of beta-adrenoceptor agonists and antagonists on gastric emptying in man. Br J Clin Pharmacol. 1980 Dec;10(6):551–554. doi: 10.1111/j.1365-2125.1980.tb00509.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schemann M., Ehrlein H. J. Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology. 1986 Apr;90(4):991–1000. doi: 10.1016/0016-5085(86)90878-4. [DOI] [PubMed] [Google Scholar]
  17. Stanghellini V., Malagelada J. R., Zinsmeister A. R., Go V. L., Kao P. C. Effect of opiate and adrenergic blockers on the gut motor response to centrally acting stimuli. Gastroenterology. 1984 Nov;87(5):1104–1113. [PubMed] [Google Scholar]
  18. Stanghellini V., Malagelada J. R., Zinsmeister A. R., Go V. L., Kao P. C. Stress-induced gastroduodenal motor disturbances in humans: possible humoral mechanisms. Gastroenterology. 1983 Jul;85(1):83–91. [PubMed] [Google Scholar]
  19. Thompson D. G., Binfield P., De Belder A., O'Brien J., Warren S., Wilson M. Extra intestinal influences on exhaled breath hydrogen measurements during the investigation of gastrointestinal disease. Gut. 1985 Dec;26(12):1349–1352. doi: 10.1136/gut.26.12.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thompson D. G., Richelson E., Malagelada J. R. Perturbation of gastric emptying and duodenal motility through the central nervous system. Gastroenterology. 1982 Dec;83(6):1200–1206. [PubMed] [Google Scholar]
  21. Thompson D. G., Richelson E., Malagelada J. R. Perturbation of upper gastrointestinal function by cold stress. Gut. 1983 Apr;24(4):277–283. doi: 10.1136/gut.24.4.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WOLFF H. H. The mechanism and significance of the cold pressor response. Q J Med. 1951 Jul;20(79):261–273. [PubMed] [Google Scholar]

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